Hyperuricemia in a male Filipino population

Decker, John L.; Lane, James J.; M.D., M.P.H. William E. Reynolds

doi:10.1002/art.1780050203

Cited by 41 publications

(14 citation statements)

References 13 publications

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“…The uric acid level of 6.8 mg% is significantly higher than the mean for Caucasians in the United States (5.2 mg%) (1,5 T h e inhabitants of Samoa are Polynesian and are related to other peoples of the central and eastern Pacific, forming a part of the family which includes the Hawaiians, the Tahitians, the Tongans, and the Maoris of New Zealand and Cook Islands. T h e Samoan language is closely related to other Polynesian tongues.…”

Section: Resultsmentioning

confidence: 90%

Hyperuricemia in American Samoans

Healey

Jones

1971

Arthritis & Rheumatism

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The mean serum uric acid of 71 normal adult American Samoan men was 6.8 mg%. Serum cholesterol, electrolytes, creatinine and total protein measurements were in the usual normal range and none correlated well with the serum urate. Like other Polynesian people, gout, obesity, diabetes and ischemic heart disease seem to be common among Samoans. Hyperuricemia has been described in MATERIALS AND METHODSA mass treatment program of filariasis had been carried out in the early 1960's. From 1966 to 1968, a follow-up survey was performed in the villages of American Samoa. Additional ,blood samples for the present study were obtained from men who met the following criteria: a) in good health and taking no medication, b) no history of gout or arthritis, c) of Samoan ancestry-ie, both parents born in Samoa.Blood was drawn in the morning, usually before any occasion for feasting or drinking. The serum was separated by centrifugation, frozen, packed in dry ice and shipped by air from American Samoa to the University of Washington School of Medicine in Seattle. Sufficient serum was obtained from 71 men to permit determinations and these comprise the study group. Uric acid was measured by the enzymatic spectrophotometric method. Other determinations were run by the standard automated laboratory system. RESULTSThe mean values for serum uric acid, cholesterol, sodium, potassium, calcium, total protein, and creatinine are shown in Table 1. The uric acid level of 6.8 mg% is significantly higher than the mean for Caucasians in the United States (5.2 mg%) (1,5). The other values are within the normal range. Correlations coefficients with the uric acid were computed for all variables both singly and in combination. None correlated strongly. No variable or group of variables was a strong predictor of the uric acid and the correlations were little better than would occur with chance alone.' DISCUSSIONThe mean urate of this sample of Samoan males (6.8 mg%) is higher than that of normal Caucasian men. It is also higher +These analyses were kindly performed by Dr.

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Section: Resultsmentioning

confidence: 90%

Hyperuricemia in American Samoans

Healey

Jones

1971

Arthritis & Rheumatism

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“…Kellgren has suggested that the people of the Pacific belong to one large gouty family (1 1). Indeed, high serum uric acid levels have been reported for Maori, Cook Island and Samoan Polynesians (1 2, 13), Filipinos (14,15), Indonesian Malayans (16) (14,15) but not among those in the Philippine Islands (19). Healey et a1 have suggested that this difference may be due to an inherited defect in renal excretion of uric acid which becomes manifest when the Filipinos change to a high purine Western diet (1 9).…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic studies of serum uric acid levels among micronesians

Reed

Stallones

1972

Arthritis & Rheumatism

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Data from epidemiologic studies of Chamorro and Palauan populations of Micronesia were analyzed for associations of serum uric acid levels with other characteristics of the populations. The mean serum uric acid levels for those groups were significantly higher than those reported for Western populations, but the frequency distribution patterns were similar, being unimodal and slightly skewed toward higher values. Analysis by geographic subgroups showed differences in mean serum uric acid levels, but those differences did not follow any pattern of association with sociocultural indices. There was a general association of serum uric acid levels with total daily caloric intakes. Correlation analysis of individual characteristics indicated that serum uric acid levels were positively associated with measures of blood pressure, obesity and serum triglyceride levels. There was no consistent association with serum cholesterol or glucose levels, electrocardiogram abnormalities, smoking habits or measures of occupation, education or sociocultural attitudes. The overall impression was that, except for a possible dietary influence, the risk of hyperuricemia was more strongly associated with being a Micronesian than with geographic residence or life style.Burch and co-workers reported that Chamorros and Carolinians in the Mariana Islands have a high prevalence of hyperuricemia and gout (1). This situation offered an unusual opportunity for epidemiologic analysis of hyperuricemia; for there are subgroups of these

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“…Other studies linked the introduction of a Western diet with an increased frequency of hypertension and gout, such as with the Maori Indians or Japanese Americans [27]. The immigration of Filipinos into the United States was also associated with a marked increase in the frequency of gout and hypertension [28].…”

Section: Uric Acid Is Commonly Elevated In Patients With Hypertensionmentioning

confidence: 99%

Uric Acid and Hypertension: Cause or Effect?

et al. 2010

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Uric acid was first associated with primary hypertension in 1874, yet its role in this condition remains unclear. Historically, uric acid was thought to be a secondary response to hypertension or its associated conditions. However, more recent experimental and clinical studies suggest that uric acid could have a contributory role in the pathogenesis of elevated blood pressure. More studies are needed to help dissect the potential mechanisms by which uric acid could initiate this response. It remains possible that uric acid is a marker for xanthine oxidase-associated oxidants and that the latter could be driving the hypertensive response. However, the weight of the evidence suggests that uric acid is a true modifying and possibly causal factor for human primary hypertension. Hence, early management of hyperuricemia might delay the development of essential hypertension.

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Hyperuricemia in a male Filipino population

Cited by 41 publications

References 13 publications

Hyperuricemia in American Samoans

Hyperuricemia in American Samoans

Epidemiologic studies of serum uric acid levels among micronesians

Uric Acid and Hypertension: Cause or Effect?

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