Hyperuricemia as a Predictor of Hypertension in a Screened Cohort in Okinawa, Japan

Nagahama, Kazufumi; Inoue, Taku; Iseki, Kunitoshi; Toriumi, Takashi; Kinjo, Kozen; Ohya, Yusuke; Takishita, Shuichi

doi:10.1291/hypres.27.835

Cited by 149 publications

(102 citation statements)

References 43 publications

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“…18 Hyperuricaemia has been considered an independent predictor for hypertension incidence in longitudinal cohort studies. 19,20 We have also confirmed hyperuricaemia as a predictor of cardiovascular events in a populationbased cohort study in Taiwan. 21 Thus, the strong associations of hypertension with hyperuricaemia, diabetes and dyslipidaemia in Taiwanese women, specifically in Minnan group, indicated that the early diagnosis and management of cardiometabolic disarrangements are very important in the prevention and management of hypertension and CVD.…”

Section: Discussionsupporting

confidence: 67%

Ethnic variation in hypertension prevalence of women in Taiwan

Hwang

You

et al. 2008

J Hum Hypertens

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The prevalence and risk factors of hypertension vary in ethnic groups. This study aimed to estimate the hypertension prevalence and to compare risk factors associated with hypertension in women of four ethnic groups in Taiwan. The study subjects were participants in the Taiwanese Survey on Hypertension, Hyperglycemia and Hyperlipidemia (TwSHHH) enrolled in 2002. In this analysis, only 2810 women who were at age of 20-80 years old and whose father and mother had same ethnic background (Minnan, Hakka, Aborigines or Mainland Chinese) were included. Results showed that there were significant ethnic differences in the prevalence of hypertension, obesity indices, fasting glucose, dyslipidaemia, hyperuricaemia, history of alcohol drinking and tobacco smoking and socioeconomic status. Aborigines had the highest prevalence of hypertension (28.6%) and diabetes mellitus (8.9%), whereas the Minnan group had the second highest prevalence of hypertension (19.2%) and diabetes mellitus (7.9%). Both age and central obesity were associated with an increased prevalence of hypertension except central obesity in Mainland Chinese in all four ethnic groups. Compared with the Mainland Chinese as the referent, the multivariateadjusted odds ratio (OR) (95% CI) was 1.19 (0.63-2.26), 1.92 (1.15-3.21) and 2.03 (1.00-4.12) for Hakka, Minnan and Aborigines, respectively. Elevated body mass index (X27.0 vs o24.0 kg m À2 ) and central obesity were significantly associated with hypertension showing multivariate-adjusted OR (95% CI) of 1.68 (1.18-2.38) and 1.95 (1.48-2.57), respectively. In addition, dyslipidaemia, hyperuricaemia and diabetes associated with higher OR for hypertension in Minnan women. In conclusion, there were ethnic variations in hypertension prevalence and determinants in Taiwanese women.

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Section: Discussionsupporting

confidence: 67%

Ethnic variation in hypertension prevalence of women in Taiwan

Hwang

You

et al. 2008

J Hum Hypertens

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“…MetS is characterized by the presence of multiple common cardiovascular risk factors, such as central obesity, atherogenic dyslipidemia (hypertriglyceridemia and low high-density lipoprotein cholesterol (HDL-C)) levels, hyperglycemia and elevated blood pressure (BP). Elevated SUA levels are prevalent in patients with hypertension 1,2 and MetS, [3][4][5][6][7] and these levels can be a significant predictor of the development of hypertension 3,[8][9][10] and MetS. [11][12][13][14] Although evidence has suggested that elevated SUA levels might have a role in hypertension, 15 a causal relationship has not been established.…”

Section: Introductionmentioning

confidence: 99%

Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan

et al. 2014

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The purpose of this study was to examine the associations between serum uric acid (SUA) levels and the incidences of hypertension and metabolic syndrome (MetS) in a large screened cohort of Japanese men and women. We evaluated 4812 subjects (males, 2528; females, 2284; mean age, 47.5 years) who underwent health checkups between 2006 and 2010 and were free of hypertension and MetS in 2006. After 4 years, 618 (13%), 764 (16%) and 158 (3%) subjects developed hypertension, MetS and hypertension with MetS, respectively. Increased SUA levels were significantly and positively associated with the incidences of hypertension, MetS and hypertension with MetS. Compared with the first quartile of SUA levels, the odds ratios (95% confidence intervals) for the third and fourth quartiles, respectively, were as follows: 1.5 (1.1-2.1; P = 0.0128) and 1.8 (1.2-2.5; P = 0.0022) for hypertension, 1.3 (0.9-1.9; P = 0.1910) and 1.8 (1.2-2.7; P = 0.0039) for MetS and 2.7 (1.1-6.6; P = 0.0276) and 3.2 (1.3-8.0; P = 0.0115) for hypertension with MetS. In conclusion, increased SUA levels were significantly and independently associated with the incidences of hypertension and MetS in subjects without hypertension or MetS at baseline. Increased SUA levels might also be correlated with the incidence of hypertension with MetS.

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“…The first study, which was conducted in Finland, indicated that blood pressure levels were slightly lower in smokers than non-smokers (Karvonen et al 1959). Subsequently, numerous reports have found that smoking reduces blood pressure (Higgins and Kjelsberg 1967;Seltzer 1974;Berglund and Wilhelmsen 1975;Goldbourt and Medalie 1977;Gofin et al 1982;Agner 1983;Savdie et al 1984;Green et al 1986;Rosengren and Wilhelmsen 1987;Green et al 1991;Imamura et al 1996;Okubo et al 2002;Nagahama et al 2004;Okubo et al 2004;Wang et al 2006). In contrast, several other reports have found that smoking raises blood pressure (Elliott and Simpson 1980;Dyer et al 1982;Bolinder and de Faire 1998), while still others failed to confirm any effect on blood pressure (Arkwright et al 1982;Criqui et al 1982;Lang et al 1983;Simons et al 1984).…”

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confidence: 99%