Hyperuricemia and Serum ADA Levels in Psoriasis and their Correlation to Severity of Disease

Abstract

Introduction: Psoriasis is a chronic inflammatory autoimmune disease characterized by hyperproliferation of keratinocytes with multifactorial pathogenesis including genetic, and environmental factors. The aim of this study was to evaluate serum ADA, SUA, and ESR in psoriatic patients and their correlations with PASI score. Material and methods: Our study was a case-control study. The sample size was calculated using the Cochran formula and 50 patients of psoriasis who attended the out patient clinic at SMHS and Government medical college, srinagar were included in the study. These patients were divided according to PASI scores into three groups (mild, moderate, and severe). PASI score <10 defined psoriasis as mild, between 10 and 20 as moderate, and >20 as severe. A group of 50 healthy subjects of matched age and sex were included as a control group who were taken from amongst volunteering hospital staff and relatives. Results: This study included 50 psoriatic patients classified according to PASI score into mild, moderate, and severe psoriatic group and 50 age and sex matched controls. Out of these four patients had mild psoriasis, twelve patients had moderate psoriasis and thirty four patients had severe psoriasis according to PASI. Fifty healthy subjects were included as a control group. There were no statistically significant differences of age and sex between different patients and the control group. Conclusion: ESR, Serum Uric Acid and serum adenosine deaminase levels are significantly raised in patients with psoriasis. However there was no association with severity of disease in these patients, however, larger studies are needed to elucidate the mechanism and whether this hyperuricemia predisposes these patients to gout and increased risk of cardiovascular disease.