Hyperuricemia and risk of nonalcoholic fatty liver disease

Gong, S. L.; Song, Jiqing; Wang, Luan; Zhang, Shuaiqing; Wang, Yangang

doi:10.1097/meg.0000000000000507

Cited by 36 publications

(27 citation statements)

References 38 publications

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“…Similarly, we found that females with hyperuricemia seem to have higher NAFLD risk than males with hyperuricemia independently of age, BMI, metabolic syndrome components and other clinical variables. This result is consistent with a recent meta-analysis comprising 117,712 subjects [64]. It reported that increased NAFLD risk is markedly associated with hyperuricemia in both men (RR = 1.26, 95% CI1.15–1.37, P<0.001) and women (RR = 2.01, 95% CI1.58–2.56, P<0.001).…”

Section: Discussionsupporting

confidence: 92%

Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

Yang

Zhang

et al. 2017

PLoS ONE

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Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease associated with high levels of serum uric acid (SUA). However, whether this relationship applies in obese subjects has been unclear, and no cohort study has previously been conducted in non-obese subjects. We therefore performed a retrospective cohort study among employees of seven companies in China to investigate whether hyperuricemia was independently associated with NAFLD in obese and non-obese subjects, respectively. A total of 2383 initially NAFLD-free subjects were followed up for four years, and 15.2% (363/2383) developed NAFLD. Hyperuricemia subjects had a higher cumulative incidence than did those with normouricemia (29.0% vs. 12.9%, P<0.001). Cox proportional hazard regression analyses showed that baseline hyperuricemia was significantly associated with risk of developing NAFLD in non-obese subjects. This relationship was significantly independent of baseline age, gender, metabolic syndrome components, and other clinical variables (RR = 1.389, 95%CI: 1.051–2.099). However, this association did not exist in obese subjects (RR = 1.010, 95%CI: 0.649–1.571). The independent effect of hyperuricemia on NAFLD was stronger in females (RR = 2.138, 95%CI: 1.050–4.355) than in males (RR = 1.435, 95%CI: 1.021–2.018). In conclusion, further studies are needed to explore the different mechanisms between obese and non-obese subjects, and the reason hyperuricemia raises NAFLD risk in females more than in males.

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Section: Discussionsupporting

confidence: 92%

Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

Yang

Zhang

et al. 2017

PLoS ONE

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“…Consistent with these findings, our study found that serum UA and TG levels were significantly higher in T2DM patients with NAFLD, as compared with the T2DM without NAFLD. Our findings were supported by another large population study which showed that prevalence of NAFLD was elevated in participants with hyperuricemia [36]. We tentatively put forward that hepatic disease of NAFLD and hyperuricemia may play important roles in HTN and insulin resistance by influencing the associated inflammatory pathways.…”

Section: Discussionsupporting

confidence: 83%

Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study

Ding

Xü

Wang

et al. 2017

International Journal of Endocrinology

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The mechanisms facilitating hypertension in diabetes still remain to be elucidated. Nonalcoholic fatty liver disease (NAFLD), which is a higher risk factor for insulin resistance, shares many predisposing factors with diabetes. However, little work has been performed on the pathogenesis of hypertension in type 2 diabetes (T2DM) with NAFLD. The aim of this study is to investigate the prevalence of hypertension in different glycemic statuses and to analyze relationships between NAFLD, metabolic risks, and hypertension within a large community-based population after informed written consent. A total of 9473 subjects aged over 45 years, including 1648 patients with T2DM, were enrolled in this cross-sectional study. Clinical and biochemical parameters of all participants were determined. The results suggested that the patients with prediabetes or T2DM were with higher risks to have hypertension. T2DM with NAFLD had significantly higher levels of blood pressure, triglyceride, uric acid, and HOMA-IR than those without NAFLD. Data analyses suggested that hypertriglyceridemia [OR = 1.773 (1.396, 2.251)], NAFLD [OR = 2.344 (1.736, 3.165)], hyperuricemia [OR = 1.474 (1.079, 2.012)], and insulin resistance [OR = 1.948 (1.540, 2.465)] were associated with the higher prevalence of hypertension independent of other metabolic risk factors in type 2 diabetes. Further studies are needed to focus on these associations.

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“…A systematic review and meta-analysis by Gong et al . disclosed that hyperuricemia is associated with increased risk for nonalcoholic hepatic steatosis 28 . Studies have also shown that nonalcoholic hepatic steatosis is highly associated with metabolic syndrome, diabetes 29 , dyslipidemia, and cardiovascular disease 30, 31 .…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis

Chen

et al. 2017

Sci Rep

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Managing cardiovascular disease (CVD) risk factors is the key to prevent CVD. This study aimed to prevent CVD by introducing asymptomatic meibomian gland dysfunction (MGD), a condition associated with various CVD risk factors, as an early indicator for CVD in middle-aged population. Participants with and without asymptomatic MGD underwent standardized questionnaires, physical examinations, and laboratory investigations. One ophthalmologist completed the identification and grading of MGD by using slit-lamp biomicroscopy examination on the eyelid margins, meibomian gland orifices, and meibomian gland secretions. Standardized techniques were used to measure the CVD risk factor parameters. After adjusted for age and gender, CVD risk factors including elevated uric acid (P = 0.01), total cholesterol (Total-C, P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), fasting triglyceride (Fasting TG, P < 0.001), decreased high-density lipoprotein cholesterol (HDL-C, P = 0.04), and presence of hepatic steatosis (P = 0.008) were significantly associated with asymptomatic MGD. Stepwise logistic regression analysis revealed that LDL-C (OR: 1.03, 95% CI: 1.02–1.04) and Fasting TG (OR: 1.01; 95% CI: 1.00–1.01) levels were risk factors for having asymptomatic MGD (P < 0.001). Together, the results suggest that asymptomatic MGD may serve as an indicator for CVD.

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Hyperuricemia and risk of nonalcoholic fatty liver disease

Abstract: Hyperuricemia is associated with an increased risk of NAFLD in Asian populations. Further prospective cohort studies are needed to assess the impact of hyperuricemia on the risk of NAFLD in Western countries.

Cited by 36 publications

References 38 publications

Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study

Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a Middle-Aged Population in Taiwan - A Cross-sectional Analysis

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