Hyperuricemia and Its Associated Factors Among Adult Staff Members of the Ethiopian Public Health Institute, Ethiopia

Abstract

Background: Hyperuricemia is related not only to an increased risk of gouty arthritis but also to an increased risk of cardiovascular diseases, resistant hypertension, insulin resistance and progression of type 2 diabetes mellitus. However, to the best of our knowledge, the prevalence of hyperuricemia and its associated factors have rarely been assessed in Ethiopian populations. Therefore, this study aimed to determine the prevalence of hyperuricemia and its associated factors among adult staff members of the Ethiopian Public Health Institute. Methods: An institution-based cross-sectional study was conducted from July 1 to October 28, 2018. A total of 402 study participants were selected using a simple random sampling technique. An interviewer-administered questionnaire was used to collect the data. A blood sample of approximately 5 mL was collected from each study participant after overnight fasting through standardized methods for biochemical tests, and analyses were carried out with an automated COBAS 6000 analyzer. Data analysis was performed by SPSS version 20 software. The factors associated with the outcome variable were identified by bivariable and multivariable logistic regression analyses, and a p value <0.05 was used to declare statistical significance. Results:The mean age of the study participants was 37.13±10.5 (mean ± SD), and 51.5% of the participants were male. The overall prevalence of hyperuricemia (>5.7 mg/dL for females and >7 mg/dL for males) was found to be 31.0%. The multivariable logistic analysis revealed that age (AOR=1.59, 95% CI 1.01-2.78), sex (AOR=1.66, 95% CI 1.02-2.70), cigarette smoking (AOR=2.05, 95% CI 1. 01-4.19) and serum low-density lipoprotein (LDL) (AOR=1.70, 95% CI 1.01-2.87) were significantly associated with hyperuricemia. Conclusion:The prevalence of hyperuricemia was relatively high compared to similar studies. Early screening for hyperuricemia in the general population, especially in those who are smokers, of older age and with high serum LDL levels, is vital to control its adverse effects at an early stage.

Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials

“…Gout is an inflammatory disease caused by purine metabolism disorder, decreased uric acid excretion or excessive production, resulting in elevated blood uric acid levels and deposition of uric acid crystals in joints and other connective tissues ( 130 ). The typical clinical manifestations of joint swelling and pain are not only joint deformities, but also kidney damage, cardiovascular and cerebrovascular diseases, etc., which seriously affect the quality of life of patients ( 131 ). The occurrence and development of gout is directly related to the level of blood uric acid in the body, and uric acid is the final metabolite of purine compounds.…”

Association Between Triglyceride-Glucose Index and Serum Uric Acid Levels: A Biochemical Study on Anthropometry in Non-Obese Type 2 Diabetes Mellitus Patients

“…The renal function decreases by 10% for every 10 years of age after 40 years of age. 67 Therefore, older patients are at a significantly higher risk of HUA. Our study result was different from the results of previous research possibly because the patients enrolled in the present study are at the median in the CKD I phase (median eGFR: >90 mL/min/1.73 m 2 ).…”

Prevalence of hyperuricemia and associated factors among officials working at Tu Mo Rong district, Kon Tum province

“…Các yếu tố nguy cơ DOI: 10.34071/jmp.2023. 5.29 của tăng axit uric máu bao gồm tuổi cao, giới nam, hút thuốc lá, sử dụng rượu bia, ít hoạt động thể lực, ăn nhiều đạm [8], [10]. Nghiên cứu này giúp đưa ra những khuyến cáo giúp phòng ngừa tình trạng tăng axit uric máu trong cộng đồng.…”

“…Yếu tố rối loạn lipid máu Kết quả nghiên cứu này cho thấy giảm HDL-C có liên quan đến tăng axit uric máu, cụ thể là giảm HDL-C có nguy cơ tăng axit uric cao gấp 4,7 lần so với nhóm bình thường; chưa tìm thấy mối liên quan giữa tăng cholesterol, tăng LDL-C và tăng triglycerid với tăng axit uric máu trong nghiên cứu này. Tuy vậy, một số các nghiên cứu trước đây cho thấy tăng cholesterol, tăng LDL-C và tăng triglycerid có liên quan đến tăng axit uric máu [8] [9] Hút thuốc lá Khi đưa yếu tố hút thuốc lá vào mô hình hồi quy đa biến thì kết quả cho thấy những người hút thuốc lá có nguy cơ tăng axit uric cao gấp 3,5 lần những người không hút (p < 0,05). Kết quả này tương đồng với nghiên cứu của Lê Viết Hoàng khi cho thấy hút thuốc có mối tương quan thuận với tăng axit uric máu [5].…”