Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort

Chuang, Shao-Yuan; Chen, Jiunn-Horng; Yeh, Wen-Ting; Wu, Chih‐Cheng; Pan, Wen‐Harn

doi:10.1016/j.ijcard.2011.06.055

Cited by 70 publications

(64 citation statements)

References 49 publications

(66 reference statements)

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“…Previous studies have also reported a relationship between HUA and CAD [4, 10–12]. Some of the results confirmed a strong association between HUA and CAD; however, most of the results focused on the relationship between HUA and the risk of CAD in a middle-aged and elderly population [11, 13].…”

Section: Discussionmentioning

confidence: 85%

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Liu

Zhou

et al. 2018

BMC Cardiovasc Disord

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BackgroundCoronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is associated with CAD; however, the interaction effect between HUA and smoking on CAD is uncertain. Therefore, this study was designed to determine the relationship and interactive effects of HUA and smoking on the risk of CAD in young adults ≤ 35 years of age.MethodsIn this observational study we consecutively included adults (18–35 years of age) with suspected CAD who underwent coronary angiography for the first time in our institution from January 2005 to December 2015. Patients with stenosis affecting ≥50% of the luminal diameter and acute myocardial infarction were considered to have CAD. A serum uric acid (SUA) level ≥ 7.0 mg / dl (420 mmol / L) in males and ≥ 6.0 mg / dl (357 mmol / L) in females was defined as hyperuricemia. We tested for an interaction between HUA and cigarrete smoking on CAD. The relationship between HUA, cigarrete smoking, and CAD was assessed by multivariate logistic regression analysis.ResultsA total of 1113 participants were included in this study; 771 participants were confirmed to have CAD. HUA was present in 34.8% of the participants. HUA was significantly higher in the CAD group (odds ratio [OR], 1.34; 95% confidence interval [CI], 1.02–1.76; p = 0.035). More smokers were in the CAD group (OR, 1.59; 95% CI, 1.22–2.07; p = 0.001). Based on multivariate regression analysis and after adjustment for age, BMI, high LDL-C level, low HDL-C level, hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, diabetes mellitus, and hypertension, HUA was shown to be strongly associated with the presence of CAD in non-smokers (OR, 1.84; 95% CI, 1.03–3.29; p = 0.039). We further demonstrated that the interaction between HUA and cigarrete smoking achieved statistical significance for the presence of CAD (p = 0.008).ConclusionsIn the current study, HUA was shown to be associated with the presence of CAD in non-smokers ≤ 35 years of age.Electronic supplementary materialThe online version of this article (10.1186/s12872-018-0910-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 85%

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Liu

Zhou

et al. 2018

BMC Cardiovasc Disord

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“…Are there any differences in the risk factors between the two groups? 2) They conducted Cox proportional hazard model regression analysis for subjects with and without metabolic risk factors, separately ( Table 3 in [1]). In case of women without metabolic risk actors, the effect of hyperuricemia on IHD incidence showed no significance.…”

Section: To the Editormentioning

confidence: 99%

“…

Chuang et al presented a 7-year follow-up study on the effect of uric acid on the occurrence of ischemic heart disease (IHD), adjusted by age, metabolic factors, lifestyles, medication and working type [1]. They used popular variables in the health examination targeting 128,569 subjects.

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mentioning

confidence: 99%

Serum uric acid and ischemic heart disease incidence

Kawada

2012

International Journal of Cardiology

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“…Hyperuricemia was defined as the serum uric acid level >7.0mg/dL in males and >6.0mg/dL in females [15]. CKD was defined as the presence of either decreased estimated GFR or albuminuria [1].…”

Section: Definitions Of Hyperuricemia and Chronic Kidney Diseasementioning

confidence: 99%

Gender Difference in the Association of Hyperuricemia with Chronic Kidney Disease in Southern China

Liu

Mao

et al. 2012

Kidney Blood Press Res

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Background: The effect of hyperuricemia on chronic kidney disease (CKD) is controversial, and little is known about gender as it relates to hyperuricemia and CKD. Methods: This was a cross-sectional study of 7,053 adults in the general Chinese population in Southern China using a multi-stage stratified sampling method. In which associations between hyperuricemia and indicators of CKD (defined by albuminuria (urinary albumin-to -creatinine ratio ≥ 30mg/g) or decreased modified MDRD equation estimated GFR (<60ml/min per 1.73m²) were tested using multivariate logistic regression. Results: After adjustment for potential confounders, hyperuricemia was associated with increased risk of reduced renal function and CKD but not albuminuria, with odds ratios (ORs) (95% CI) of 4.39 (3.38-5.70, P <0.001), 1.54 (1.31-1.82, P <0.001) and 0.96 (0.78-1.17, P =0.671), respectively. The interaction between gender and hyperuricemia with CKD was significant (P =0.010); and stratified analysis showed a stronger association of hyperuricemia with CKD in males (OR (95% CI): 2.04 (1.56-2.67), P <0.001) than in females (1.45 (1.17-1.80), P =0.001). Conclusions: We observed an independent association of hyperuricemia with CKD that was stronger in males, and this independent association in male might imply some gender specific mechanisms. These results should be confirmed in future prospective studies.

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Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort

Cited by 70 publications

References 49 publications

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Serum uric acid and ischemic heart disease incidence

Gender Difference in the Association of Hyperuricemia with Chronic Kidney Disease in Southern China

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