Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies

Zuo, Tian; Li, Xuehui; Jiang, Lu; Mao, Shuai; Yin, Xin; Guo, Liheng

doi:10.1186/s12872-016-0379-z

Cited by 133 publications

(110 citation statements)

References 59 publications

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“…Previous studies have also reported a relationship between HUA and CAD [4, 10–12]. Some of the results confirmed a strong association between HUA and CAD; however, most of the results focused on the relationship between HUA and the risk of CAD in a middle-aged and elderly population [11, 13].…”

Section: Discussionmentioning

confidence: 85%

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Liu

Zhou

et al. 2018

BMC Cardiovasc Disord

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BackgroundCoronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is associated with CAD; however, the interaction effect between HUA and smoking on CAD is uncertain. Therefore, this study was designed to determine the relationship and interactive effects of HUA and smoking on the risk of CAD in young adults ≤ 35 years of age.MethodsIn this observational study we consecutively included adults (18–35 years of age) with suspected CAD who underwent coronary angiography for the first time in our institution from January 2005 to December 2015. Patients with stenosis affecting ≥50% of the luminal diameter and acute myocardial infarction were considered to have CAD. A serum uric acid (SUA) level ≥ 7.0 mg / dl (420 mmol / L) in males and ≥ 6.0 mg / dl (357 mmol / L) in females was defined as hyperuricemia. We tested for an interaction between HUA and cigarrete smoking on CAD. The relationship between HUA, cigarrete smoking, and CAD was assessed by multivariate logistic regression analysis.ResultsA total of 1113 participants were included in this study; 771 participants were confirmed to have CAD. HUA was present in 34.8% of the participants. HUA was significantly higher in the CAD group (odds ratio [OR], 1.34; 95% confidence interval [CI], 1.02–1.76; p = 0.035). More smokers were in the CAD group (OR, 1.59; 95% CI, 1.22–2.07; p = 0.001). Based on multivariate regression analysis and after adjustment for age, BMI, high LDL-C level, low HDL-C level, hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, diabetes mellitus, and hypertension, HUA was shown to be strongly associated with the presence of CAD in non-smokers (OR, 1.84; 95% CI, 1.03–3.29; p = 0.039). We further demonstrated that the interaction between HUA and cigarrete smoking achieved statistical significance for the presence of CAD (p = 0.008).ConclusionsIn the current study, HUA was shown to be associated with the presence of CAD in non-smokers ≤ 35 years of age.Electronic supplementary materialThe online version of this article (10.1186/s12872-018-0910-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 85%

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Liu

Zhou

et al. 2018

BMC Cardiovasc Disord

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“…For instance, higher SUA levels appear to be protective against progression of Parkinson’s disease in men, but not women [21]. Other lines of research show that the association between SUA and cardiovascular disease is stronger in women compared to men [22–25]. For instance, a recent meta-analysis found that hyperuricemia had a stronger association with coronary heart disease mortality in women compared to men [25].…”

Section: Introductionmentioning

confidence: 99%

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging

Kueider‐Paisley

Tanaka

et al. 2017

JAD

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Serum uric acid (SUA) is an abundant natural antioxidant capable of reducing cellular oxidation, a major cause of neurodegenerative disease. In line with this, SUA levels are lower in Alzheimer’s disease; however, the association between SUA and cognition remains unclear. Results from studies examining the effects of SUA on cognition may be difficult to interpret in the context of normal versus pathological aging. This study examined sex-specific associations of baseline SUA with cognition during aging. Data from dementia-free participants initially aged 26–99 (N = 1,451) recruited for the Baltimore Longitudinal Study of Aging (BLSA), were used in the current analyses. SUA was assessed using blood samples collected during research visits. Cognition was measured using five composite scores (verbal memory, attention, executive function, language, and visuospatial ability). At the first study visit, compared with women, men were older, more likely to be White, had more years of education, higher baseline SUA levels, and higher cardiovascular risk scores. Higher baseline SUA was associated with attenuated declines in attention (β = 0.006; p = 0.03) and visuospatial abilities (β = 0.007; p = 0.01) in men. There was a trend to suggest higher baseline SUA in men was associated with attenuated declines in language, but this finding did not reach statistical significance (p = 0.09). There were no significant findings with SUA and cognition in women. In this sample of cognitively healthy, community-dwelling adults, we found that higher SUA levels at baseline were associated with attenuated declines in attention and visuospatial abilities in men. SUA was not associated with cognition or change in cognition over time in women.

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“…High SUA levels are a strong and independent marker of impaired prognosis in patients with moderate-to-severe chronic heart failure 11 . In addition, a recent meta-analysis found that hyperuricemia might increase the risk of coronary heart disease and all-cause mortality 12 .…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid and atrial fibrillation

Manolis¹

2017

Current Medical Research and Opinion

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Background: Atrial fibrillation (AF) represents a significant health concern, due to the increased prevalence, morbidity, and mortality. Methods and Results: There is a growing body of evidence correlating serum uric acid (SUA) with cardiovascular diseases such as arterial hypertension and AF. Conclusion: Thus, a question arises as to whether SUA levels have a role in the pathophysiology of AF development.

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Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies

Cited by 133 publications

References 59 publications

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Hyperuricemia and smoking in young adults suspected of coronary artery disease ≤ 35 years of age: a hospital-based observational study

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging

Serum uric acid and atrial fibrillation

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