Hyperuricemia and Cardiovascular Disease

Zhang, Shuangshuang; Wang, Yong; Cheng, Jinsong; Huangfu, Ning; Zhao, Ruochi; Xu, Zhenyu; Zhang, Fuxing; Zheng, Wenyuan; Zhang, Dandan

doi:10.2174/1381612825666190408122557

Cited by 111 publications

(66 citation statements)

References 103 publications

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“…At present, the relationship between serum uric acid level and carotid intima-media thickness has become a research hotspot, but the research results are controversial. A number of studies have found that the serum uric acid level is independently related to CIMT thickening [9,10], but some scholars have concluded that there is no significant correlation between SUA level and IMT values in men or women [11][12][13][14]. These studies indicated that whether serum uric acid levels can be considered an independent risk factor for carotid atherosclerosis remains highly controversial [15].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Wang

Huang

et al. 2021

PLoS ONE

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Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for statistical analysis. The standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated by a random effect model to estimate the correlation. Publication bias was assessed using the Begg and Egger tests. The stability of these results was evaluated using sensitivity analyses. Results Fifteen studies were included with a total sample size of 11382, including 7597 participants in the high uric acid group and 3785 in the control group, on the basis of the inclusion and exclusion criteria. According to the evaluation of the JBI scale, the literature was of high quality. The average age ranged from 42 to 74. Meta-analysis showed that CIMT in the high uric acid group was significantly higher than that in the control group (SMD = 0.53, 95% CI: [0.38, 0.68]), and the difference was significant (z = 6.98, P < 0.00001). The heterogeneity among the 15 articles was obvious (I2 = 89%, P < 0.00001). Subgroup analysis by disease status illustrated a positive relationship between SUA and CIMT in healthy people and people with diseases. SUA was shown to be positively correlated with CIMT in people aged 45–60 years and ≥60 years by subgroup analysis by age. SUA was also found to be positively correlated with CIMT in a population with BMI>24 kg/m2 by subgroup analysis by BMI. In addition, subgroup analysis of other risk factors for CIMT, including TC, SBP, DBP, triglycerides, and LDL-C, all showed a positive correlation between SUA and CIMT. Conclusions There is a significant correlation between serum uric acid level and carotid intima-media thickness, and a high concentration of serum uric acid is related to carotid artery intima-media thickness.

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Section: Introductionmentioning

confidence: 99%

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Wang

Huang

et al. 2021

PLoS ONE

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“…These present results were in accordance with the recent case-control studies that focused on the causal relationship between uric acid and metabolic syndrome, and several cardiovascular diseases. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] However, conflicting results were still present. Parsa et al 21 reported that a decrease in serum uric acid has a causal effect of lowering blood pressure through the method of Mendelian randomization analysis in 516 Amish adults.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that hyperuricemia plays a putative pathogenetic role for cardiovascular diseases. [1][2][3][4] One potential mechanism that links uric acid-mediated pathways to cardiovascular disease is arterial stiffening. Brachial-ankle pulse wave velocity (baPWV), which can be non-invasively measured, has been considered as a widely recognized measure of arterial stiffness 5,6 Numerous studies have reported the association between levels of circulating uric acid and arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

The relationship between elevated serum uric acid and arterial stiffness in a healthy population

Jiang

Zhang

et al. 2020

Vascular

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Objective This study aims to investigate the relationship between serum uric acid and arterial stiffness in a healthy population. Methods Among the 979 participants, baPWV was non-invasively measured, the circulating levels of uric acid were tested, and the uric acid polymorphisms (rs2231142 and rs11722228) were genotyped. Then, the Mendelian randomization method was employed to test the relationship between serum uric acid and arterial stiffness in a healthy population. Results After adjusting for age, gender, antihypertensive medication, body mass index, waist-to-hip ratio, urea nitrogen, creatinine and diabetic mellitus, there was a significant allelic difference in uric acid levels for each genotype ( P < 0.0001 for rs2231142; P = 0.007 for rs11722228). However, there were no differences on the potential confounders between the genotypes of rs2231142 and rs11722228 ( P > 0.05). The baPWV was significantly associated with circulating levels of uric acid after adjusting for cardiovascular risk factors and other potential confounders ( P = 0.002). However, neither the single polymorphism, nor the accumulation of culprit alleles was associated with baPWV ( P = 0.92 for rs2231142; P = 0.60 for rs11722228; P for trend = 0.77 for the combined analysis of culprit alleles). Conclusion These results do not support the causal role of circulating levels of uric acid in the development of arterial stiffness.

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“…Many studies have shown a relationship between hyperuricemia and cardiovascular disease (Kostka-Jeziorny et al, 2019;Kowalski et al, 2009;Zhang et al, 2019). Several studies on hyperuricemia patients have reported SUA concentration as a marker of pathophysiology processes that correlated with the development of cardiovascular disease (Zhang et al, 2019). Only a few studies have investigated the correlation between SUA concentration and cardiovascular disease in patients without hyperuricaemia.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum uric acid concentration and cardiovascular risk factors in normotensivepostmenopausal women with dyslipidemia [pdf]

Dobrzyńska¹,

Przysławski²

2020

Acta Sci Pol Technol Aliment

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Background. According to the latest recommendation for patients with hyperuricemia and high cardiovascular risk, the serum uric acid (SUA) concentration should be lower than 5 mg/dL (<298 μmol/L). Additionally, studies have shown that SUA concentration in participants with hyperuricemia correlates with some dietary factors. The aim of this study was to assess the relationship between SUA concentration and some cardiovascular risk factors. Material and methods. Fifty-six postmenopausal women with dyslipidemia and without hypertension were assigned to 2 groups based on SUA concentration. The first group consisted of women with a SUA concentration ≥5 mg/dL and without gout, and the second group comprised women with a SUA concentration <5 mg/dL. Anthropometric parameters, nutrition, structure of consumption, dietary potential renal acid load (PRAL), lipid profile parameters and blood pressure were evaluated. Results. Postmenopausal women with a SUA ≥5 mg/dL had statistically significant higher values of serum triglyceride (TG) concentration, waist-to-hip ratio (WHR) and diastolic blood pressure than women with a SUA concentration <5 mg/dL. Analysis of nutrition showed statistically significant differences between the groups in the intake of starch, saturated and polyunsaturated fatty acids, cholesterol and vitamin E. Additionally, we observed a correlation between PRAL value and SUA. The structure of consumption between the groups was varied. Conclusion. SUA concentration ≥5 mg/dL may increase the cardiovascular risk. The association observed between PRAL and SUA can be used to evaluate diet.

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Hyperuricemia and Cardiovascular Disease

Cited by 111 publications

References 103 publications

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

The relationship between elevated serum uric acid and arterial stiffness in a healthy population

The relationship between serum uric acid concentration and cardiovascular risk factors in normotensivepostmenopausal women with dyslipidemia [pdf]

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