Hyperuricaemia and gout: time for a new staging system?

Dalbeth, Nicola; Stamp, Lisa K.

doi:10.1136/annrheumdis-2014-205304

Cited by 128 publications

(71 citation statements)

References 29 publications

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“…Предложенная классификация фокусирует внимание на патоморфологической основе заболевания -наруше-нии обмена, гиперурикемии и формировании кристаллов МУН, а также обеспечивает рациональную основу для выявления и лечения бессимптомных форм болезни (бес-симптомная гиперурикемия) [16].…”

Section: клинические проявленияunclassified

Gouty Arthritis – Modern View of the Problem

Мазуров¹,

Петрова²,

Инамова³

et al. 2017

Med. sov.

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Section: клинические проявленияunclassified

Gouty Arthritis – Modern View of the Problem

Мазуров¹,

Петрова²,

Инамова³

et al. 2017

Med. sov.

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“…Although the MAMAD technique was demonstrated to break down the UA and MSUM crystals, the size of formation, which is presented in the advance stages of gout [42]. The plastic pouch used is representative of the synovial membrane that encases the joint cavity in which UA crystals deposit in humans.…”

Section: Decrystallization Of L-alanine Crystals (A Model Tophi)mentioning

confidence: 99%

Metal-Assisted and Microwave-Accelerated Decrystallization: An Alternative Approach to Potential Treatment of Crystal Deposition Diseases

Thompson¹,

Kukoyi²,

Lansiquot³

et al. 2017

Clin Arch Bone Joint Dis

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Gout is a painful and prevalent crystal deposition disease caused by the overproduction of Uric Acid (UA) in the body and the atypical deposition in human synovial joints as Monosodium Urate Monohydrate (MSUM). Conventional treatments, such as NSAIDs, cyclooxygenase-2 inhibitors, and systemic glucocorticoids often present harmful side-effects and are short-lived. Long-term therapies including xanthine oxidase inhibitors and the use of uricosuric agents have been developed and aim to lower the UA serum levels in the body. As regards to post-crystals deposition, our research laboratory recently proposed and demonstrated the use of the Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the breakdown of organic and biological crystals on planar surfaces. The MAMAD technique is based on the combined use of microwave heating and Au NPs in solution. The interactions of the Au NPs with microwave's electromagnetic field result in an increase in the kinetic energy of Au NPs, and subsequently, an increase in the collisions with target crystals placed on planar surfaces leading to rapid crystal breakdown. In this regard, our laboratory aims to develop the MAMAD technique as an alternative treatment for crystal deposition diseases, particularly gout, with minimal invasion and side-effects as compared to current treatments. In this review article, we will summarize our previous findings and provide additional data detailing the effectiveness of the MAMAD technique as a rapid and efficient method for the breakdown of gout related crystals and L-alanine crystals (a model crystal).

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“…The natural history of gout includes four different phases: asymptomatic hyperuricemia, acute attacks, intercritical phase, and chronic tophaceous gout [6]. Initially, acute attacks (that typically resolve without therapy in 7 to 10 days) alternate with asymptomatic periods.…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal ultrasonography in gout

et al. 2015

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Gout is a frequent inflammatory disease induced by the deposition of monosodium urate crystals in joints and extraarticular tissues. The natural history of the disease includes four different phases: asymptomatic hyperuricemia, acute attacks, intercritical phase, and chronic tophaceous gout. Imaging techniques have several applications in the diagnosis, clinical monitoring and management of the disease but, particularly, musculoskeletal ultrasound is able to detect a wide set of abnormalities in gout. This review reports the most relevant findings detectable by ultrasound and the current available data in the literature regarding the role of musculoskeletal ultrasound in gout.

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Hyperuricaemia and gout: time for a new staging system?

Cited by 128 publications

References 29 publications

Gouty Arthritis – Modern View of the Problem

Gouty Arthritis – Modern View of the Problem

Metal-Assisted and Microwave-Accelerated Decrystallization: An Alternative Approach to Potential Treatment of Crystal Deposition Diseases

Musculoskeletal ultrasonography in gout

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