Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with l-DOPA, homocysteine, and MTHFR genotype

Nakaso, Kazuhiro; Yasui, Kenichi; Kowa, Hisanori; Kusumi, Masayoshi; Ueda, Keigo; Yoshimoto, Yoshihide; Takeshima, Takao; Sasaki, Kiyohiro; Nakashima, Kenichiro

doi:10.1016/s0022-510x(02)00353-2

Cited by 77 publications

(60 citation statements)

References 16 publications

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“…Since Hcy also has been associated with hypertrophy of the intima-media complex of the carotid artery, a marker of atherosclerotic disease (Megnien et al, 1998), Ldopa-induced Hcy may promote systemic atherosclerosis processes, thus compromising vascular health. This is supported by the findings of Nakaso et al (2003) who reported that patients treated with L-dopa for longer duration had increased hypertrophic changes in the intima-media complex of the carotid artery, and that Hcy promoted by both longer L-dopa treatment and MTHFR T/T genotype may amplify atherosclerotic processes.…”

Section: What Could Explain the Link Between Hcy And Cognition?supporting

confidence: 65%

Idiopathic Parkinson's Disease, Vascular Risk Factors and Cognition: A Critical Review

Doiron¹,

Simard²

2012

Neurodegeneration

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Section: What Could Explain the Link Between Hcy And Cognition?supporting

confidence: 65%

Idiopathic Parkinson's Disease, Vascular Risk Factors and Cognition: A Critical Review

Doiron¹,

Simard²

2012

Neurodegeneration

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“…Levodopa therapy does, however, causes increase in serum homocysteine level as the drug is metabolized via catechol O-methyltransferase, and high level of serum homocysteine is known to be an independent risk factor for vascular diseases and cognitive impairments in elderly people [1]. Indeed, some reports have demonstrated that elevated homocysteine levels in PD patients might be associated with increased prevalence of coronary artery disease, hypertrophy of carotid artery, and peripheral neurodegeneration [2][3][4], albeit there is no clear evidence that this is related to increased stroke risk in PD patients [5,6].…”

Section: Introductionmentioning

confidence: 99%

The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: Serial transcranial Doppler studies

Yong

Lee

2010

Parkinsonism & Related Disorders

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“…Oxidative stress is a hallmark of MS [26] and antioxidant therapy leads to a decrease of severity of MS-like disease in animal models of experimental allergic encephalomyelitis (EAE) [19]. The MTHFR C677T genotype has also been shown to enhance atherosclerosis in Parkinson disease (PND), and other neurodegenerative disease [21]. The MTHFR C677T is a common mutation of the MTHFR gene with a C to T transition, located at nucleotide 677.…”

Section: Introductionmentioning

confidence: 99%

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis

Tajouri

Martin

Gasparini

et al. 2006

Brain Research Bulletin

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Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Higher blood levels of homocysteine have also been reported in MS. Thus, the C677T mutation of the MTHFR gene may influence MS susceptibility.Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT). The COMT G158A substitution results in a three-to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation.We tested DNA from Australian MS patients and unaffected control subjects, matched for gender, age and ethnicity. Specifically, we genotyped the MTHFR C677T and the COMT G158A mutations. Genotype distributions showed that the homozygous mutant MTHFR genotype (T/T) and the COMT (H/H) genotype were slightly over-represented in the MS group (16% versus 11% and 24% versus 19%, respectively), but both variations failed to reach statistical significance (P = 0.15 and P = 0.32, respectively). Hence, results from the present study do not support a major role for either functional gene mutation in MS susceptibility.

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Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with l-DOPA, homocysteine, and MTHFR genotype

Cited by 77 publications

References 16 publications

Idiopathic Parkinson's Disease, Vascular Risk Factors and Cognition: A Critical Review

Idiopathic Parkinson's Disease, Vascular Risk Factors and Cognition: A Critical Review

The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: Serial transcranial Doppler studies

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis

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