Hypertrophy causes delayed conduction in human and guinea pig myocardium: accentuation during ischaemic perfusion

Winterton, S J; Turner, Mark A.; O'gorman, D. J.; Flores, Nicholas A.; Sheridan, Desmond J.

doi:10.1093/cvr/28.1.47

Cited by 72 publications

(47 citation statements)

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“…QRS duration was increased 10 and CV decreased 11 in a guinea pig model of HF at day 150 after aortic banding; however, in the same model, CV was increased after 50 days of aortic banding. 11 This underscores the dynamic nature of HF.…”

Section: Clinical Perspective P 813mentioning

confidence: 79%

“…In guinea pig after 150 days of aortic constriction, heart size, QRS duration, 10 and intracellular resistivity 40 were increased and CV 11 was decreased. In a milder stage of HF (50 days of aortic constriction), heart size and CV were increased, 11 whereas intracellular resistivity 40 and QRS width 10 were unchanged.…”

Section: Conduction Velocitymentioning

confidence: 95%

“…In a milder stage of HF (50 days of aortic constriction), heart size and CV were increased, 11 whereas intracellular resistivity 40 and QRS width 10 were unchanged. Other studies reported a decreased subepicardial CV in the setting of HF 9 or no change.…”

Section: Conduction Velocitymentioning

confidence: 99%

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Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

et al. 2006

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Section: Clinical Perspective P 813mentioning

confidence: 79%

Section: Conduction Velocitymentioning

confidence: 95%

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Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

et al. 2006

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“…The operation was performed under anaesthesia (0-22 ml kg-' sodium pentobarbitone, followed by inhalation of a 49:49:2 N20 :02: halothane mixture) and the animal subsequently allowed to recover with post-operative analgesia (50 jug kg-' subcutaneous buprenorphine) given after wound closure. A sham (control) group, with no clip, underwent the same operative procedure (for further details see Winterton et al 1994). …”

Section: Methodsmentioning

confidence: 99%

“…Left ventricular hypertrophy induced by thoracic aortic constriction is accompanied by reduced conduction velocity, which can be explained by an increased intracellular resistivity, specifically a raised cell-to-cell resistance, and contributes to the resultant arrhythmias (Winterton, Turner, O'Gorman, Flores & Sheridan, 1994;Cooklin, Wallis, Sheridan & Fry, 1995). To evaluate the cellular basis of this phenomenon, intracellular pH (pHi) was measured in isolated myocytes from such hearts, since it has been shown that a decrease of pHi increases gap junction resistance in cell pairs (White, Spray, Campos de Carvalho, Wittenberg & Bennett, 1981).…”

Section: Introductionmentioning

confidence: 99%

Intracellular pH and H+ buffering capacity in guinea‐pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta

Wallis¹,

Wu²,

Sheridan³

et al. 1997

Experimental Physiology

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SUMMARYIntracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-tobody weight ratio and a decrease in pH1 (mean + S.D., 7.06 + 0-18 pH units in control hearts vs.6-87 + 0-17 pH units in hypertrophied hearts). Intracellular H+ buffering capacity (/l) increased as pH, fell, but the value of/1 was independent of hypertrophy per se.

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Left Ventricular Septal Hypertrophy in Elderly Patients With Aortic Stenosis

Katayama

Panse

Kendall

et al. 2017

J of Ultrasound Medicine

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Objectives-Left ventricular (LV) septal hypertrophy in aortic stenosis raises diagnostic and therapeutic questions. However, the etiology and clinical consequences of this finding have not been well studied. The aim of this study was to perform a morphologic evaluation of the LV in aortic stenosis and to investigate the contributing factors and consequences of septal hypertrophy.Methods-Patients with moderate or severe aortic stenosis were prospectively enrolled. Patients with previous myocardial infarction, wall motion abnormalities, at least moderate valvular regurgitation, known cardiomyopathy, an LV ejection fraction of less than 50%, and age younger than 65 years were excluded.Results-Forty-one patients underwent a final analysis. Septal hypertrophy (LV septal wall thickness 15 mm) was confirmed in 21 of 41 patients. The septal hypertrophy group had higher peak aortic valve velocity, a higher diabetes mellitus rate, and a higher rate and longer duration of hypertension than those without septal hypertrophy. The peak aortic valve velocity (odds ratio, 7.1; 95% confidence interval, 1.4-37.1) and diabetes mellitus (odds ratio, 7.4; 95% confidence interval, 1.2-46.2) were the significant factors associated with septal hypertrophy by multivariate analysis. Intraventricular conduction disturbance on electrocardiography was more frequent in the septal hypertrophy group (P 5 .021).Conclusions-Left ventricular septal hypertrophy was commonly observed in elderly patients with aortic stenosis, and a higher aortic valve velocity, hypertension, and diabetes mellitus were associated factors. Intraventricular conduction disturbance occurred more often in patients with septal hypertrophy than those without, which implies the pathophysiologic consequence. Further studies are needed to determine the impact of septal hypertrophy and intraventricular conduction disturbance on the prognosis of patients after aortic valve interventions.Key Words-aortic stenosis; echocardiography (adult); electrocardiology; magnetic resonance imaging; valvular heart disease A symmetric hypertrophy, especially basal septal hypertrophy, has been identified as a variant in patients with aortic stenosis. However, the etiology and clinical consequences of this entity have not been well investigated: specifically, whether clinical factors such as hypertension, age, and the severity of aortic stenosis predispose patients to septal hypertrophy development and whether this hypertrophy has a causal effect for physiologic abnormalities. When septal thickness is excessive, differential diagnoses of hypertrophic cardiomyopathy or other infiltrative diseases need to be considered. Additionally, septal hypertrophy has an impact on clinical management that may dictate the choice of surgical procedure (traditional

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Hypertrophy causes delayed conduction in human and guinea pig myocardium: accentuation during ischaemic perfusion

Abstract: Delayed conduction is an important feature of severe cardiac hypertrophy in guinea pigs and man. Hypertrophy is associated with accentuated conduction delay and altered repolarisation during ischaemia.

Cited by 72 publications

References 0 publications

Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

Intracellular pH and H+ buffering capacity in guinea‐pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta

Left Ventricular Septal Hypertrophy in Elderly Patients With Aortic Stenosis

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