Hypertrophic pulmonary osteoarthropathy secondary to bronchial adenocarcinoma and coexisting pulmonary tuberculosis: a case report

Abstract

A 44-year-old man presented with painful swelling of wrists and ankles, severe pain at both tibiae, clubbing of fingers and toes and arthritis in wrist and ankle joints. The chest roentgenogram showed consolidation of the right lower lobe, whereas plain roentgenograms revealed solid periosteal reaction at both tibiae. CT and bronchoscopy confirmed the presence of adenocarcinoma of the right lower lobe. Moreover, mycobacterium of tuberculosis was isolated by culture of the patient's sputum.Our patient received antituberculous treatment and soon he underwent surgical excision of the tumour and subsequent chemotherapy. Ten months later, he returned with metastatic lesions in the brain and the adrenals. A few days later, he died.The patient suffered from bronchial adenocarcinoma as well as pulmonary tuberculosis. As a complication of these two coexisting conditions, the patient developed hypertrophic pulmonary osteoarthropathy.

Hypertrophic osteoarthropathy as the cause of situs inversus totalis: A case report

“…The lesions are usually bilateral and symmetric causing swelling and extreme pain of the affected limbs. It may occur as a primary condition, which is familial and affects mainly males [6], but most of the times is the manifestation of other conditions characterized by arte riovenous shunt like lung carcinoma, mesothelioma, pulmonary tuberculosis, congenital cyanotic heart disease, hepatic and colorectal carcinoma, inflammatory bowel disease, cirrhosis, pulmonary fibrosis and empyema [7,8].…”

Hypertrophic pulmonary osteoarthropathy with primary lung cancer

“…Lesi biasanya bilateral dan simetris dengan keluhan bengkak dan nyeri pada persendian, tungkai dan lengan yang terkena. 1,2,3,4 Sidik tulang (bone scintigraphy) merupakan pemeriksaan 'gold standar' pada metastasis tulang dan sangat sensitif untuk mendiagnosis HPO. Berikut ini dipaparkan laporan kasus pasien laki-laki usia 58 tahun dengan karsinoma bronkogenik dan HPO.…”

“…Pasien dengan riwayat merokok sejak 30 tahun yang lalu sebanyak 3-4 bungkus/hari. 1,3,4 Sidik tulang merupakan modalitas pencitraan yang sangat sensitif untuk mendeteksi perubahan fungsional pada tulang termasuk HPO. Sidik tulang dengan menggunakan radiofarmaka 99mTc-MDP dapat memperlihatkan gambaran HPO lebih awal dibandingkan modalitas pencitraan yang lain.…”

Hypertrophic Pulmonary Osteoarthropathy Secondary Lung Cancer, Demonstrated on Scintigraphic Study

“…İlk kez 19. Yüz yılın sonlarında Marie ve Bamberget tarafından tanımlanmıştır 1,2 . Sendromun patogenezi ile ilgili bazı hipotezler ileri sürülse de kesin olarak bilinmemektedir.…”