Hypertrophic osteopathy associated with systemic granulomatous disease in a horse

Abstract

A 4-year-old Criollo stallion was presented at the equine clinic of veterinary hospital of the Federal University of Santa Maria, RS, with a 30-day history of progressive weight loss, anemia and swelling of the forelimbs and face. Physical examination revealed that the swelling was firm and had a bone-like consistency, also radiographs showed extensive periosteal proliferation on the forelimb long bones that suggested hypertrophic osteopathy (Marie´s disease). Physical examinations identified no respiratory findings. However, during ultrasound examination, superficial lung disease was identified. The animal was treated with antibiotics and nonsteroidal anti-inflammatory drugs for 12 days. Due to a complete lack of response to this treatment, the horse was euthanized. At necropsy several granulomatous lesions were identified in the thorax, abdomen and testicular tunics. Bony proliferation was evident on many bones of the appendicular skeleton and face. Based on these findings the diagnosis of hypertrophic osteopathy associated with sarcoidosis was established. It is important to perform a thorough clinical examination and include hypertrophic osteopathy in the differential diagnosis of diseases that are accompanied by swelling of the face and limbs as edema from various causes, fibrous osteodystrophy, for example. aumento de volume era firme e apresentava consistência óssea. Radiografias também mostraram extensa proliferação periosteal nos ossos longos dos membros anteriores, o que sugeriu a osteopatia hipertrófica (doença de Marie). Os exames físicos não identificaram alteração respiratória. No entanto, durante o exame ultrassonográfico, foi identificada doença pulmonar superficial. O animal foi tratado com antibióticos e anti-inflamatórios não esteróides durante 12 dias. Devido a uma completa falta de resposta ao tratamento, o cavalo foi sacrificado. Durante a necropsia, várias lesões granulomatosas foram identificadas no tórax, abdômen e túnicas testiculares. Proliferação óssea era evidente em vários ossos do esqueleto apendicular e da face. Com base nestes resultados o diagnóstico de osteopatia hipertrófica associada à sarcoidose foi estabelecido. É importante realizar um exame clínico completo e incluir a osteopatia hipertrófica no diagnóstico diferencial de enfermidades que vêm acompanhadas de aumento de volume da face e dos membros como edema por diversas causas e osteodistrofia fibrosa, por exemplo. Palavras-chave: Pulmonar. Periósteo. Sarcoidose. Patologia.

Hypertrophic osteoarthropathy in a sheep

“…This article described the clinical, radiological and anatomopathological findings of a case of hypertrophic osteoarthropathy in a ram. Hypertrophic osteoarthropathy is an unusual disease in farm animals (MAIR et al, 1996;GUYOT et al, 2011;BROWNE et al, 2016;KWIRANT et al, 2016), but it is common in humans (YAP et al, 2017). Although, the term osteoarthropathy is not widely used in veterinary medicine (CONSTABLE et al, 2017), we highlighted that in this case, because its use better represents the lesions observed since they clearly affected the joints.…”

“…Bom et al GUYOT et al, 2011;BROWNE et al, 2016;KWIRANT et al, 2016;CONSTABLE et al, 2017); therefore, this research aimed to describe the radiological, clinical and pathological aspects of a case of hypertrophic pulmonary osteoarthropathy in a sheep.…”