Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition

Ballestero, Matheus Fernando Manzolli; Viana, Dinark Conceição; Teixeira, Thiago Afonso; Santos, Marcelo Volpon; Oliveira, Ricardo Santos de

doi:10.1007/s00381-017-3705-6

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…HOD is a rare complication after posterior fossa tumor surgery. 2 HOD after posterior fossa surgery usually presents with posterior fossa syndrome ("cerebellar mutism") rather than typical oculo-palatal myoclonus, unlike in our case. 3 To the best of our knowledge, palatal myoclonus has never been reported in postsurgical cases of pediatric medulloblastoma.…”

Section: Videocontrasting

confidence: 53%

Olivary Hypertrophy Induced Palatal Myoclonus in a Treated Case of Medulloblastoma

Singh,

Lakhanpal,

et al. 2024

Neuropediatrics

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Section: Videocontrasting

confidence: 53%

Olivary Hypertrophy Induced Palatal Myoclonus in a Treated Case of Medulloblastoma

Singh,

Lakhanpal,

et al. 2024

Neuropediatrics

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“…Hypertrophic olivary degeneration is an infrequent condition, especially in the paediatric population. So far there were only 14 publications describing a total of 39 cases of HOD in children after posterior fossa surgery [4].…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic olivary degeneration in a 16-year-old girl after subtotal surgery of a brainstem pilocytic astrocytoma – a case report

Sobieraj¹,

Duczkowski²,

Terczyńska³

et al. 2019

Pol J Radiol

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Purpose Hypertrophic olivary degeneration (HOD) is a unique neurological condition caused by interruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain and Mollaret. Magnetic resonance (MR) imaging is the best modality to diagnose both the degeneration of the inferior olivary nucleus and the underlying cause. Case report We describe a case of a unilateral HOD in a 16-year-old girl several months after a subtotal excision of a brainstem pilocytic astrocytoma. Taking into account the patient’s history, tumour recurrence must have been considered, but the typical location and MR morphology, as well as the time of occurrence after brainstem surgery, contributed to the diagnosis of HOD. The causative factor was the interruption of the central tegmental tract, which forms one arm of the Guillain and Mollaret triangle. Additionally, this is an interesting case of a child, who stayed in a coma for several months following brainstem surgery, but finally was discharged home with only minor neurological defects and returned to normal life. Conclusions Hypertrophic olivary degeneration is an infrequent neurological condition, especially in the paediatric population. Nevertheless, it should be considered when interpreting late postoperative scans of children with a history of a brain tumour.

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“…Among reported cases, the vast majority are bilateral HOD with identifiable lesions. 19 The majority of reported cases in this population are secondary to posterior fossa syndrome following brain tumor resection. 20 Children appear to have more clinical symptoms compared to their adult counterparts.…”

Section: Hod In the Pediatric Populationmentioning

confidence: 98%

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

2021

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Hypertrophic olivary degeneration is a rare condition caused by a lesion in the Guillain-Mollaret triangle which leads to trans-synaptic degeneration resulting in the degenerative hypertrophy of the inferior olivary nucleus. This condition presents clinically with palatal tremor but can also produce ocular myoclonus or cerebellar signs. While any lesion that occurs within the Guillian-Mollaret triangle and results in the deafferentation of the inferior olive can lead to hypertrophic olivary degeneration, the most common etiologies include ischemic and hemorrhagic stroke, vascular malformation, neoplasm, and iatrogenic injury related to surgery. We report a series of 7 patients who presented with this condition bilaterally on MRI imaging, including 1 case which represents the first report of toxoplasmosis leading to the development of bilateral hypertrophic olivary degeneration and only the third reported case, unilateral or bilateral, related to an infectious etiology.

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Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition

Abstract: HOD is a rare complication related after PF tumors surgery and symptoms may be misdiagnosed with pediatric cerebellar mutism syndrome. Children with HOD usually do not develop palatal tremor but ataxia is common.

Cited by 7 publications

References 33 publications

Olivary Hypertrophy Induced Palatal Myoclonus in a Treated Case of Medulloblastoma

Olivary Hypertrophy Induced Palatal Myoclonus in a Treated Case of Medulloblastoma

Hypertrophic olivary degeneration in a 16-year-old girl after subtotal surgery of a brainstem pilocytic astrocytoma – a case report

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

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