Hypertrophic Lichen Planus in West African Negroes

Clarke, G. H. V.

doi:10.1001/archderm.1951.01570090061008

Cited by 2 publications

(2 citation statements)

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“…It is a frequently itchy dermatosis and it can present itself with annular, linear, bullous or atrophic lesions. [1][2][3] Hypertrophic lichen planus (HLP) represents the variety of LP in which the epidermis presents marked hyperplasia, due to persistent itching, being considered by some authors as a superposition of a chronic simple lichen to the LP lesions. 4 It is reported here a case of HLP with excellent response to oral treatment with acitretin.…”

Section: Introductionmentioning

confidence: 99%

“…2 Preceptress at the Department of Dermatology from the University of Mogi das Cruzes (UMC) -Mogi das Cruzes (SP), Brazil. 3 Preceptor of the Department of Dermatology at the Marcílio Dias Naval Hospital -Rio de Janeiro (RJ), Brazil. 4 Preceptor and Head of the Department of Dermatopathology of the Dermatology service from the Federal Hospital of Bonsucesso (HFB) -Rio de Janeiro (RJ), Brazil.…”

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Líquen plano hipertrófico disseminado: relevante resposta à acitretina

Jaime

Guaraldi

et al. 2011

An. Bras. Dermatol.

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Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment. Keywords: Acitretin; Immunosuppressive drugs; Lichen planus; Prednisone Resumo: O líquen plano hipertrófico é uma variante do líquen plano, com pronunciada hiperplasia epidér-mica em resposta à coçadura persistente. Clinicamente, caracterizam-se por placas hiperceratósicas, simétri-cas, de coloração cinza-violácea, com predileção pela região pré-tibial. O prurido intenso, a refratariedade aos tratamentos convencionais e a possibilidade de associação de um carcinoma epidermoide às lesões de longa duração impõem um tratamento eficaz. Os corticoides são considerados o tratamento de primeira linha e podem ser aplicados topicamente ou empregados de forma sistêmica. Outras modalidades terapêu-ticas propostas são a fototerapia com UVB-NB ou PUVA, imunossupressores e retinoides sistêmicos, com destaque para a acitretina. Relatamos um caso com apresentação clínica exuberante e excelente resposta à acitretin, totalizando um seguimento de nove meses.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%