Hypertrophic Cardiomyopathy Phenotype Revisited After 50 Years With Cardiovascular Magnetic Resonance

Abstract

Although diverse, patterns of LV hypertrophy are usually not extensive in HCM, involving < or = 50% of the chamber in about one-half the patients, and are particularly limited in extent in an important minority. Contiguous portions of anterior free wall and septum constituted the predominant region of wall thickening, with implications for clinical diagnosis. These observations support an emerging role for CMR in the contemporary evaluation of patients with HCM.

Impact of Demographic Features, Lifestyle, and Comorbidities on the Clinical Expression of Hypertrophic Cardiomyopathy

“…In most patients, HCM is caused by mutations in genes encoding proteins of the cardiac sarcomere 1, 2, 3, 4. Symptoms include dyspnea on exertion, fatigue, angina, atypical chest pain, syncope, and palpitations.…”

O diagnóstico da obstrução da via de saída do ventrículo esquerdo na cardiomiopatia hipertrófica

“…Hypertrophic segments alternate with normal ones in a pattern not detected in other heart diseases. The number of hypertrophic segments is greater in hypertrophic obstructive forms than in nonobstructive ones 70 . The LV mass is related to maximum wall thickness and gradient at rest.…”

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

“…It is hard to differentiate the lateral epicardial border of the LV myocardium from the adjacent thoracic parenchyma and the epicardial border of the posterior septum in the area of insertion of the right ventricular (RV) free wall by echocardiography due to loss of spatial resolution. CMR is not limited by such constraints and it is superior to echocardiography for assessing LV wall thickness on the anterior wall, posterior septum and apex of the heart due to its tomographic imaging capability and higher spatial resolution [3,8]. Maron et al [8] described different patterns of LVH in 333 HCM patients utilizing CMR.…”