Hypertrophic Cardiomyopathy After Heart Transplantation

Gao, Hans; Kransdorf, E.; Ebinger, Joseph; Kittleson, M.

doi:10.1016/j.jaccas.2023.101825

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2023

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“…The emergence of an ApHCM phenotype in a transplanted heart suggests a genetic susceptibility to this form of HCM in the donor heart [ 5 , 25 ]. Current protocols do not mandate genetic screening for HCM among potential donors in the absence of a known familial history.…”

Section: Discussionmentioning

confidence: 99%

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An Unusual Presentation of Apical Hypertrophic Cardiomyopathy in an Orthotopic Heart Transplant Recipient

Molina-Lopez,

Engel-Rodriguez,

Diaz-Rodriguez

et al. 2023

Cureus

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In this case study, we present the evaluation of an orthotopic heart transplant (OHT) patient who presented with persistent shortness of breath and dizziness upon standing. The investigation uncovered the presence of progressive hypertrophic cardiomyopathy (HCM) in the transplanted heart, a condition first detected 11 years after the transplantation. Utilizing echocardiography with global longitudinal strain (GLS), we determined that the HCM likely originated from genetic predominance inherited from the heart donor rather than hypertensive disease. This finding highlights the significance of genetic factors in post-transplant complications and warrants further investigation into the long-term effects of heart transplantation on recipient health.

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Section: Discussionmentioning

confidence: 99%

“…Cases of ApHCM in OHT are a unique occurrence in the medical literature. Addressing them requires specialized clinical approaches due to the limited established therapies [ 4 - 5 ].…”

Section: Introductionmentioning

confidence: 99%