Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in
PLIN1
-Related Lipodystrophy
Bruno Vergès,
Marie-Christine Vantyghem,
Yves Reznik
et al.
Abstract:BACKGROUND:
Pathogenic variants in
PLIN1
-encoding PLIN1 (perilipin-1) are responsible for an autosomal dominant form of familial partial lipodystrophy (FPL) associated with severe insulin resistance, hepatic steatosis, and important hypertriglyceridemia. This study aims to decipher the mechanisms of hypertriglyceridemia associated with
PLIN1
-related FPL.
METHODS:
… Show more
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