Hypertriglyceridemia is a risk factor for treatment failure in patients with peritoneal dialysis-related peritonitis

Huang, Yajuan; Jiang, Zongpei; Zhou, Ja-Fan; Zhang, Xing; Xiong, Liping; Liang, Mengjun; Shi, Hongrui; Su, Ning; Zhang, Rui

doi:10.1007/s11255-021-03027-x

Cited by 7 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our research, we found that with the increase of BSA, the blood lipid indexes (triglyceride, cholesterol, and low-density lipoprotein) of patients showed a downward trend instead. Some researchers noted that hypertriglycerides could worsen the infection and was an independent risk factor for treatment failure of PDAP [40]. This was consistent with our research results.…”

Section: Discussionsupporting

confidence: 93%

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Zhang

2023

Ther Apher Dial

View full text Add to dashboard Cite

IntroductionThis study mainly discussed the relationship between body surface area (BSA) and treatment failure of peritoneal dialysis‐associated peritonitis (PDAP).MethodsThe exposures were BSA grouped by the tertiles of BSA levels. The association between BSA and the risk of treatment failure in PDAP, defined as the temporary or permanent switch to hemodialysis and kidney transplantation, was evaluated in Cox proportional hazards models.ResultsA total of 483 episodes in 285 patients were recorded in our center. As a three‐level categorical variable, in reference to G3, the G1 of BSA displayed a 4.054‐fold increased venture of treatment failure in a fully adjusted model. In sensitivity analysis, a lower value of BSA (G1) was identified as an independent risk factor for peritonitis episodes (odds ratio = 2.433, 95% confidence interval: 1.184–4.999, p = 0.015).ConclusionA lower level of body surface area was remarkably associated with a higher incidence of treatment failure among peritoneal dialysis‐associated peritonitis episodes.

show abstract

Section: Discussionsupporting

confidence: 93%

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Zhang

2023

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…HDL particles inhibit staphylococcus aureus virulence-mediated functions, including activation, attraction, and lyses of neutrophils in vitro and in vivo 12 . However, another study investigating the relationship between lipid disorders and PD suggested that HDL levels were associated with treatment failure based on univariate analysis 13 . Observational studies have demonstrated that HDL can lose its anti-in ammatory and antioxidant functions and paradoxically adopt proin ammatory characteristics and promote systemic oxidative stress, as is seen in chronic in ammatory disorders 14 .…”

Section: Risk Factorsmentioning

confidence: 99%

“…Furthermore, high-density lipoprotein (HDL) was a protective factor (OR = 0.24 [0.07,0.81], P = 0.004). Compared to gram-positive peritonitis, gram-negative (OR = 4.14 [1.42,12.08], P = 0.009) and culture-negative (OR = 3.72 [1.002,13.82], P = 0.049) peritonitis had higher risks of technique failure.According to Kaplan-Meier analysis, patients experiencing technique failure-related peritonitis had lower post-peritonitis survival (log-rank = 20.346, P < 0.0001). Similar mortality was observed among patients with and without technique failure-related peritonitis during the rst 3 years after recovery; however, beyond 3 years, patients with technique failure experienced higher mortality rates.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Survival Analysis and Associated Factors of Technique Failure in Peritoneal Dialysis-Related Peritonitis: A Single-Center Study

Yü

Zhu

Tong

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The risk factors associated with technique failure-related peritonitis and the effect of technique failure on patient survival were also assessed. Methods We retrospectively reviewed patients with PDRP between January 1, 2010, and February 1, 2016. Relevant demographic, biochemical, and clinical data were collected. Univariate and multivariate logistic regression analyses were used to determine technique failure-related peritonitis predictors. Patients were divided into the technique failure (F group) and non-technique failure (NF group) groups. The median follow-up was 96 months (IQR, 76–112). Kaplan-Meier survival curves were used to investigate post-peritonitis survival of the technique failure-related peritonitis cohort. Landmark analysis was also used to determine the survival rate of the technique failure-related peritonitis cohort. Results A total of 165 patients with 272 cases of PDRP were included. Multivariate logistic regression analysis identified that peritoneal dialysis (PD) duration (OR = 1.2 [1.04,1.39], P = 0.014) and neutrophil-to-lymphocyte ratio (NLR) (OR = 0.27 [0.09,0.79], P = 0.017) were independent predictors for technique failure in PDRP. Furthermore, high-density lipoprotein (HDL) was a protective factor (OR = 0.24 [0.07,0.81], P = 0.004). Compared to gram-positive peritonitis, gram-negative (OR = 4.14 [1.42,12.08], P = 0.009) and culture-negative (OR = 3.72 [1.002,13.82], P = 0.049) peritonitis had higher risks of technique failure. According to Kaplan–Meier analysis, patients experiencing technique failure-related peritonitis had lower post-peritonitis survival (log-rank = 20.346, P < 0.0001). Similar mortality was observed among patients with and without technique failure-related peritonitis during the first 3 years after recovery; however, beyond 3 years, patients with technique failure experienced higher mortality rates. Conclusions PD duration, NLR, gram-negative, and culture-negative peritonitis were independent risk factors for technique failure, while HDL was a protective factor. Technique failure-related peritonitis had adverse effects on post-peritonitis survival.

show abstract

“…The association between HDL and peritonitis-associated treatment failure is controversial. A study investigated the relationship between lipid disorders and peritoneal dialysis (PD) treatment and found that based on the univariate analysis, there was an association between HDL levels and treatment failure [ 24 ]. Our study suggested that HDL was a significant protective factor against technique failure, which is similar to the results of previous studies [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Technique failure in peritoneal dialysis-related peritonitis: risk factors and patient survival

Yü

Zhu

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Objective This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The effect of peritonitis-associated technique failure on patient survival was also assessed. Methods Patients diagnosed with PDRP from January 1, 2010 to June 30, 2022 were retrospectively reviewed and analyzed. Relevant demographic, biochemical, and clinical data were collected. Univariate and multivariate logistic regression analyses were used to determine the predictors of peritonitis-associated technique failure in PD. Patients were divided into technique failure (F group) and nontechnique failure (NF group) groups. Patients were followed until death or until the date of Oct 1, 2022. Kaplan–Meier survival curves and landmark analysis were used to assess the survival of the PDRP cohort. Cox regression models were used to assess the association between potential risk factors and mortality. Results A total of 376 patients with 648 cases of PDRP were included in this study. Multivariate logistic regression analysis demonstrated that peritoneal dialysis (PD) duration (OR = 1.12 [1.03, 1.21], p = 0.005), dialysate WBC count on Day 3 after antibiotic therapy (OR = 1.41 [1.22, 1.64], p = 0.001), blood neutrophil-to-lymphocyte ratio (NLR) (OR = 1.83 [1.25, 2.70], p = 0.002), and serum lactate dehydrogenase (LDH) (OR = 4.13 [1.69, 10.11], p = 0.002) were independent predictors for technique failure in PDRP. Furthermore, serum high-density lipoprotein (HDL) (OR = 0.28 [0.13, 0.64], p = 0.002) was a protective factor against technique failure. According to the Kaplan–Meier analysis, patients experiencing peritonitis-associated technique failure had lower postperitonitis survival (log-rank = 4.326, p = 0.038). According to the landmark analysis, patients with a history of peritonitis-associated technical failures had a higher 8-year mortality after peritoneal dialysis. A Cox model adjusted for plausible predetermined confounders showed that technique failure was independently associated with all-cause mortality. Conclusions Dialysate WBC count on Day 3, PD duration, NLR, and LDH were independent risk factors for technique failure, whereas HDL was a protective factor. Peritonitis-associated technique failure had a higher risk of mortality and adverse effects on postperitonitis survival.

show abstract

Hypertriglyceridemia is a risk factor for treatment failure in patients with peritoneal dialysis-related peritonitis

Cited by 7 publications

References 28 publications

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Survival Analysis and Associated Factors of Technique Failure in Peritoneal Dialysis-Related Peritonitis: A Single-Center Study

Technique failure in peritoneal dialysis-related peritonitis: risk factors and patient survival

Contact Info

Product

Resources

About