Hypertriglyceridemia in Different Degrees of Glucose Intolerance in a Finnish Population-Based Study

Salomaa, Veikko; Tuomilehto, Jaakko; Jauhiainen, Matti; Korhonen, Heikki; Stengård, Jari H.; Uusitupa, Matti; Pitkänen, Matti; Penttilä, Ilkka

doi:10.2337/diacare.15.5.657

Cited by 30 publications

(21 citation statements)

References 31 publications

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“…1,4 The prevalence of hypertriglyceridemia is three times higher in men with type 2 diabetes compared to men with normal glucose tolerance, 28 and high total and VLDL triglycerides are independent and powerful predictors of CHD in type 2 diabetes. 4,5 Indeed, type 2 diabetic patients with serum triglycerides above 2.3 mmolal have a 2-fold increased risk of CHD.…”

Section: Discussionmentioning

confidence: 99%

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

et al. 2001

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OBJECTIVE:To investigate the effect of an exercise training program on lipid pro®le in correlation with DHEA level and body weight and body composition in type 2 diabetic men. DESIGN: Longitudinal, controlled clinical intervention study with exercise training consisting of an 8 week supervised program of aerobic exercise (75% VO 2 peak, 45 min), twice a week and intermittent exercise, once a week, on a bicyle ergometer. SUBJECTS: Sixteen men (age 45.4 AE 7.2 y (mean AE s.d.), HbA1c 8.15 AE 1.7%, body mass index (BMI) 29.6 AE 4.6 kgam 2 ) were randomly divided into two groups: trained group (n 8) and control group (n 8 P`0.001), and DHEA levels (11.00 AE 3.10 vs 14.25 AE 4.10 nmolal, P`0.05) with no modi®cation in body weight. Changes in triglycerides were negatively correlated with changes in DHEA (r À0.81, P 0.03). This correlation was independent of changes in abdominal fat distribution. CONCLUSION: Training decreases abdominal fat depots, improves muscular mass and affects favourably triglyceride and DHEA levels. Changes in triglycerides and DHEA were inversely related.

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Section: Discussionmentioning

confidence: 99%

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

et al. 2001

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“…The partial correlations of Fig 6 suggest that metabolic factors associated with insulin resistance and elevated triglycerides could mediate in part the reduction in HDL 2b associated with adiposity. Salomma et al [40] have hypothesized the primacy of insulin resistance in mediating associations between adiposity and lipoproteins in men. Taskinen et al [41] reported that insulin therapy increases HDL 2 and reduces HDL 3 concomitant to a twofold increase in adipose tissue lipoprotein lipase activity.…”

Section: Insulinemia and Adipositymentioning

confidence: 99%

The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The stanford coronary risk intervention project baseline survey

et al. 1995

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We used nondenaturing polyacrylamide gradient gel electrophoresis to examine the associations of high-density lipoprotein (HDL) subclasses with adiposity, physical activity, resting heart rate (an indicator of sympathetic drive), and plasma insulin and glucose levels in 97 men with angiographically documented coronary artery disease. These men neither smoked nor used medications known to affect lipoproteins. The absorbency of protein stain was used as an index of mass concentrations at intervals of 0.01 nm within five HDL subclasses: HDL 3c (7.2 to 7.8 nm), HDL 3b (7.8 to 8.2 nm), HDL 3a (8.2 to 8.8 nm), HDL 2a (8.8 to 9.7 nm), and HDL 2b (9.7 to 12 nm). HDL peak diameter was determined from the predominant peak of the HDL particle distribution when plotted against particle diameter. Four men who were non-insulin-dependent diabetics as defined by a fasting glucose exceeding 140 mg/dL had significantly higher plasma HDL 3b levels and significantly smaller HDL peak diameters than nondiabetic men, and were therefore excluded from further analyses. In the remaining 93 nondiabetic men, plasma HDL 3b levels correlated positively with indices of truncal obesity (waist to hip ratio and subscapular skinfold), whereas plasma HDL 2b levels correlated negatively with indices of total adiposity (body mass index [BMI]) and truncal obesity (subscapular and abdominal skinfold). Fasting plasma insulin levels correlated negatively with HDL 3a , HDL 2a , and HDL 2b . Obesity significantly affected the relationships of resting heart rate with insulin and HDL subclasses. In heavier men (BMI > 25.8 kg/m 2 ) but not in the less-obese men (BMI < 25.8 kg/m 2 ), resting heart rate was negatively correlated with HDL 3a , HDL 2a , and HDL 2b levels and HDL peak diameter and positively correlated with fasting plasma insulin concentrations. Although the reported physical activity in heavier men also correlated with HDL 3a , HDL 2a , and resting heart rate, the associations of resting heart rate with HDL 3a , HDL 2a , and HDL 2b could not be attributed to activity level. These analyses suggest that the influences of plasma insulin, regional adiposity, physical activity, and resting heart rate on HDL involve specific HDL subclasses. In the presence of increased adiposity, sympathetic drive and physical inactivity may reduce levels of larger HDL and the peak diameter of the major HDL subspecies.

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“…5,8 Higher TG is also a feature of prediabetic subjects. [12][13][14][15][16] Insulin resistance and/or B-cell failure in prediabetic and diabetic subjects may be responsible for higher TG in these subjects. Studied in FDRs have shown raised TG 9,10 and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…11 But there are very limited studies to find lipid abnormalities in each prediabetic groups. High level of TG was found in IFG, IGT, IFG-IGT, [12][13][14][15][16] and low HDL in IFG and IGT. [13][14][15] Probably insulin resistance and/or secretion defect in these subjects have role for this dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Lipid Abnormalities in the Natural History of Diabetes

Rahman

Ali

2015

J. Medicine

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Hypertriglyceridemia in Different Degrees of Glucose Intolerance in a Finnish Population-Based Study

Abstract: Hypertriglyceridemia is common in subjects with NIDDM and IGT and is often associated with low HDL cholesterol, high total cholesterol, hyperinsulinemia, and elevated serum uric acid concentration.

Cited by 30 publications

References 31 publications

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The stanford coronary risk intervention project baseline survey

Lipid Abnormalities in the Natural History of Diabetes

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