Hypertrabeculation; a phenotype with Heterogeneous etiology

Adabifirouzjaei, Fatemeh; Igata, Sachiyo; DeMaria, Anthony N.

doi:10.1016/j.pcad.2021.07.007

Cited by 8 publications

(9 citation statements)

References 119 publications

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“…The third criterion, elaborated by Stollberger et al is suggestive of LV hypertrabeculation in the presence of more than 3 trabeculations at the LV level, visible in the same section. [8,9] Therefore, the diagnosis established after the CMR examination was DCM due to LV hypertrabeculation, considering the areas of accentuated trabeculations and the presence of Petersen, Jacquier and Stacey criteria. The distribution of LGE is also highly suggestive for LV hypertrabeculation cardiomyopathy.…”

Section: Case Presentationmentioning

confidence: 99%

What can a cryptogenic stroke hide in a young patient?

Cepoi,

Vrabie,

Ponor

et al. 2023

Romanian Journal of Cardiology

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Introduction Left ventricular hypertrabeculation is a recently described ventricular phenotype characterized by the alternation of excessive trabeculations with deep intertrabecular recesses that communicate with the left ventricular cavity but not with the coronary circulation. Case presentation We report the case of a young patient, recently diagnosed with ischemic stroke, in whom the cardiological assessment revealed the coexistence of left ventricular hypertrabeculation and dilated cardiomyopathy, which pathologies associated with a high risk of embolic events. The treatment administered followed the therapy for chronic heart failure, control of rhythm disorders that might occur, and the prevention of embolic accidents. Conclusions The particularity of the case is represented by atypical onset through a complication of the disease in a cardiovascular paucisymptomatic patient. Multimodal imaging corroborated with clinical and anamnestic elements had an essential role in the diagnosis.

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Section: Case Presentationmentioning

confidence: 99%

What can a cryptogenic stroke hide in a young patient?

Cepoi,

Vrabie,

Ponor

et al. 2023

Romanian Journal of Cardiology

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“…Different diagnostic strategies have been proposed; however, none are generally accepted. Adabifirouzjaei and colleagues proposed the valuation of the left ventricular function in patients in whom the hypertrabeculation was found on echocardiography or CMR [ 64 ]. In patients with normal EF and no associated conditions, a family screening of first-degree relatives should be performed.…”

Section: Differential Diagnosismentioning

confidence: 99%

Left Ventricular Non-Compaction Cardiomyopathy-Still More Questions than Answers

Paluszkiewicz

Milting

Kałużna‐Oleksy

et al. 2022

JCM

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Left ventricular non-compaction (LVNC) describes the phenotypical phenomena characterized by the presence of excessive trabeculation of the left ventricle which forms a deep recess filled with blood. Considering the lack of a uniform definition of LVNC as well as the “golden standard” it is difficult to estimate the actual incidence of the disease, however, seems to be overdiagnosed, due to unspecific diagnostic criteria. The non-compacted myocardium may appear both as a disease representation or variant of the norm or as an adaptive phenomenon. This article covers different approaches to incidence, pathogenesis, diagnostics, and treatment of LVNC as well as recommendations for patients during follow-up.

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“…This has led to the concept of hypertrabeculation as a pathomorphology for which noncompaction syndrome is only one etiology (Figure 9). 14,15 Studies have demonstrated that contrast identification of hypertrabeculation and decreased compacted myocardial thickness has adverse prognostic significance in patients with left ventricular dilation and advanced dysfunction. Preclinical studies initially demonstrated that the direct intracoronary injection of CO 2 was capable of intensely opacifying the myocardium, thereby providing the potential to assess myocardial perfusion and coronary blood flow 16 (Figure 10).…”

Section: Left Ventricular Border Definitionmentioning

confidence: 99%

Section: Hypertrabeculation and Noncompaction Cardiomyopathymentioning

confidence: 99%

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Established and emerging roles for ultrasound enhancing agents (contrast echocardiography)

Cotter

Raisinghani

DeMaria

2022

Clinical Cardiology

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The ability to opacify the left ventricle and delineate the endocardium after intravenous injection of microbubble ultrasound enhancing agents is of established value to quantify volumes and function in suboptimal unenhanced images, particularly in stress echocardiograms. However, applications other than quantitation of left ventricle structure and function exist for contrast enhanced left ventricular opacification. Contrast agents enable recording of Doppler velocity signals in patients with poor ultrasound transmission, providing estimates of aortic stenosis gradient and pulmonary artery pressures. Contrast echo is of value in detecting apical hypertrophic cardiomyopathy and accompanying apical aneurysms. Most importantly, ultrasound enhancing agents can identify apical and left atrial masses when they cannot be visualized in unenhanced images, and can distinguish thrombi from tumors by visualizing the vascularity inherent in tumors. Contrast agents distinguish trabecular from compacted myocardium in noncompaction syndrome, and hypertrabeculation with other abnormal conditions. A major potential application of ultrasound enhancing agents is myocardial opacification, which can assist in identifying nonviable myocardium. Also, the delayed reappearance of myocardial perfusion after microbubble destruction identifies impaired contrary flow and can diagnose coronary stenosis. Innovative applications of ultrasound contrast agents currently under investigation, include visualizing the vaso vasorum to identify plaques and assess their vulnerability, and theranostic agents to deliver drugs and biologists and to assist in sonothrombolysis. It is anticipated that the role of ultrasound contrast agents will continue to increase in the future.

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Hypertrabeculation; a phenotype with Heterogeneous etiology

Cited by 8 publications

References 119 publications

What can a cryptogenic stroke hide in a young patient?

What can a cryptogenic stroke hide in a young patient?

Left Ventricular Non-Compaction Cardiomyopathy-Still More Questions than Answers

Established and emerging roles for ultrasound enhancing agents (contrast echocardiography)

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