Abstract:SummaryMechanical responses such as twitch and tetanus were markedly reduced in Xenopus single twitch fibers which were previously treated with either 125 mM NaCI or 250 mM sucrose hypertonic Ringer despite the retention of nearly normal action potential and caffeine contracture. This inhibition of excitation-contraction coupling was accompanied by a large reduction in membrane capacity to approximately 2,uF/cm2 during and after immersion in the hypertonic Ringer and can possibly be attributed to the same orig… Show more
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