Hypertonic Saline Treatment of Acid Aspiration-Induced Lung Injury

Hyperosmolarity enhances the lung capillary barrier

“…Our findings are consistent with several previous studies in which intravenous hyperosmolar infusions were reported to prevent lung injury (5)(6)(7)(8). However, for the consideration of hyperosmolar infusion in clinical therapy, the role of the endothelium must be further clarified especially with regard to the manner in which barrier protection is initiated and is maintained in intact models of lung injury.…”

“…Hyperosmolar infusions, which are commonly applied in resuscitation therapy (4), suppress lung injury (5)(6)(7)(8), inhibit expression of endothelial leukocyte adhesion molecules (8,9), and block the proinflammatory effects of lipopolysaccharide (8). Furthermore, hyperosmolar infusions expand blood volume (10,11) and cause hemodilution (10), suggesting that the capillary barrier remains intact despite the potential cellshrinkage effect of hyperosmolarity (12).…”

Partial liquid ventilation with FC-77 suppresses the release of lipid mediators in rat acute lung injury model

“…The rat model of acid aspiration has been shown to present lung injury and an increase in serum humoral mediators (15).…”

ICU mortality is increased with high admission serum osmolarity in all patients other than those admitted with pulmonary diseases and hypoxia

“…Hence, the need for novel therapeutics option is imperative. Hyperosmolarity has been shown to be lung protective in multiple experimental and basic science studies of ARDS . However, hyperosmolarity has not been associated with better clinical outcomes in patients with lung injury.…”

“…Hyperosmolarity has been shown to be lung protective in multiple experimental and basic science studies of ARDS. [3][4][5][6][7] Correspondence: Shailesh Bihari…”