Hypertonic Saline Resuscitation After Mesenteric Ischemia/Reperfusion Induces Ileal Apoptosis

Gonzalez, Ernest A.; Kozar, Rosemary A.; Suliburk, James W.; Weisbrodt, Norman W.; Mercer, David; Moore, Frederick A.

doi:10.1097/01.ta.0000188935.66504.00

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…The only common pathway exhibited by hibernation and IPC is that there are variations in intestinal blood flow patterns which lead to intestinal mucosal preservation. Intestinal injury is triggered by the ischemia/reperfusion sequence that produces a local and systemic inflammatory response, promotes apoptosis, and generates reactive oxygen species [25][26][27]. We conducted global gene expression profiling using microarrays to characterize the gene changes occurring in ileum of rats subjected to early and late ischemic preconditioning to begin to dissect the molecular basis for the phenomenon of IPC described above.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Ischemic Preconditioning After Ischemia/Reperfusion Injury in Rat Intestine: Profiling Global Gene Expression Patterns

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Intestinal Ischemic Preconditioning After Ischemia/Reperfusion Injury in Rat Intestine: Profiling Global Gene Expression Patterns

et al. 2009

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“…29 The concept of a beneficial effect of hyperosmolality is corroborated by in vivo studies showing that hypertonic solutions improve cardiac function in children after open-heart surgery 30 and improve the outcome after hemorrhagic shock. 31-34 …”

Section: Discussionmentioning

confidence: 99%

Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network

Reinhart

Piety

Goede

et al. 2015

Microvascular Research

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Plasma sodium concentration is normally held within a narrow range. It may, however, vary greatly under pathophysiological conditions. Changes in osmolality lead to either swelling or shrinkage of red blood cells (RBCs). Here we investigated the influence of suspension osmolality on biophysical properties of RBCs and their ability to perfuse an artificial microvascular network (AMVN). Blood was drawn from healthy volunteers. RBC deformability was measured by osmotic gradient ektacytometry over a continuous range of osmolalities. Packed RBCs were suspended in NaCl solutions (0.45, 0.6, 0.9, 1.2, and 1.5 g/dL), resulting in supernatant osmolalities of 179±4, 213±1, 283±2, 354±3, and 423±5 mOsm/kg H2O. MCV (mean corpuscular volume) and MCHC (mean corpuscular hemoglobin concentration), were determined using centrifuged microhematocrit. RBC suspensions at constant cell numbers were used to measure viscosity at shear rates ranging from 0.11 to 69.5 s−1 and the perfusion rate of the AMVN. MCV was inversely and MCHC directly proportional to osmolality. RBC deformability was maximized at isosmotic conditions (290 mOsm/kg H2O) and markedly decreased by either hypo- or hyperosmolality. The optimum osmolality for RBC suspension viscosity was shifted towards hyperosmolality, while lower osmolalities increased suspension viscosity exponentially. However, the AMVN perfusion rate was maximized at 290 mOsm/kg H2O, and changed by less than 10% over a wide range of osmolalities. These findings contribute to the basic understanding of blood flow in health and disease, and may have significant implications for the management of osmotic homeostasis in clinical practice.

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“…This endothelial dysfunction is characterized by endothelial cell tight junction breakdown, inflammation, and leukocyte diapedesis (36,37). The leaky endothelium induced by traumatic shock is susceptible to excessive crystalloid resuscitation and unbalanced blood product administration, which leads to tissue injury, interstitial edema, acute respiratory distress syndrome and multiple organ failure (38). Plasma is thought to reverse the "endotheliopathy" induced by HS by restoring tight junctions and the glycocalyx, and inhibiting inflammation thus minimizing leakage of fluid across the leaky endothelium (39).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Early Resuscitation with Fresh Frozen Plasma for Traumatic Brain Injury Combined with Hemorrhagic Shock Improves Neurologic Recovery

Halaweish

Bambakidis

et al. 2015

Journal of the American College of Surgeons

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Hypertonic Saline Resuscitation After Mesenteric Ischemia/Reperfusion Induces Ileal Apoptosis

Abstract: HS resuscitation after mesenteric I/R significantly increased ileal mucosal apoptosis while decreasing mucosal injury and may represent a novel mechanism by which HS resuscitation after mesenteric I/R reduces inflammation and imparts protection to the gut.

Cited by 11 publications

References 36 publications

Intestinal Ischemic Preconditioning After Ischemia/Reperfusion Injury in Rat Intestine: Profiling Global Gene Expression Patterns

Intestinal Ischemic Preconditioning After Ischemia/Reperfusion Injury in Rat Intestine: Profiling Global Gene Expression Patterns

Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network

Early Resuscitation with Fresh Frozen Plasma for Traumatic Brain Injury Combined with Hemorrhagic Shock Improves Neurologic Recovery

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