Hypertonic glucose solution 10% - 25% on the mesenterium and peritoneum of the rat: macroscopic and microscopic study

Carvalho, José Cícero Ferreira de; Leal, Antenor Teixeira; Sousa, Luis Ferreira de; Filho, Benedito Herani

doi:10.1590/s0102-86502005000600011

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…These materials increase the cost of surgery and have unreliable effects in the prevention of adhesions 2 , 6 . Several other substances with different mechanisms of action, such as cow peritoneum, amniotic membranes or liquids, oxidized celluloses, olive oil, soybean oil, starch, glycerol, honey, diluted glucose, corticosteroids, and many others have been tried to prevent the formation of postoperative peritoneal adhesion 2 , 6 – 8 , 12 , 13 , 22 , 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies evaluating the macroscopic and microscopic changes in the mesentery and parietal peritoneum in rats have administered 10 and 25% hypertonic glucose aqueous solutions to the peritoneal cavity of rats and have observed the absence of tissue necrosis and inflammation with the same intensity in the mesentery and parietal peritoneum 13 . This result led to the choice of only one dose of hypertonic glucose (10%) in this study.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have confirmed this effect in vivo 9 – 12 . One of the experimental studies performed indicated that this solution promotes faster, more resistant healing and less inflammatory reaction than 0.9% saline solution 13 . The mechanism of action remains controversial, but the low cost of the product, its large supply, and its easy clinical applicability contribute to its clinical use.…”

Section: Introductionmentioning

confidence: 99%

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Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

et al. 2021

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Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – glucose (10%) and dexamethasone 3 mg·kg –1 ; and G3 – physiological saline (PS) 0.9%. Results In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0–1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2: 2, and G3: 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1). Conclusions The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

et al. 2021

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Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Shahnazi

Badakhsh

Azadmehr

et al. 2014

International Scholarly Research Notices

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Surgical operation is the treatment of choice for hydatid cyst. To date, many protoscolicidal substances have been used for inactivation of hydatid cyst contents but most of these compounds may produce several side effects. The aim of this study was to evaluate the protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst at different concentrations and exposure times. Protoscolices were obtained aseptically from the livers of slaughtered sheep at Qazvin abattoir, Iran. Protoscolices were exposed to different concentrations of hypertonic glucose (10%, 15%, 20%, 25%, 30%, 40%, and 50%) at different times (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, and 60 min). Viability of protoscolices was evaluated by 0.1% eosin and the movement of protoscolices flame cells. The highest protoscolicidal effect (100%) of hypertonic glucose was obtained at concentrations 40% and 50% following 40 and 20 min exposure times, respectively. Some protoscolicidal agents show a variety of dangerous complications such as biliary tract fibrosis and liver necrosis; however, hypertonic glucose especially at a concentration of 40% may demonstrate less side effects compared with glucose 50%. Further in vivo investigations are suggested.

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Hypertonic glucose solution 10% - 25% on the mesenterium and peritoneum of the rat: macroscopic and microscopic study

Abstract: Hypertonic glucose solution and NaCl 0.9% on the mesenterium and parietal peritoneum do not produce tissue necrosis in a rat and the inflammation process has the same intensity.

Cited by 2 publications

References 7 publications

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

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