Hyperthyroidism induced autoimmune myocarditis. Evaluation by Cardiovascular Magnetic Resonance and endomyocardial biopsy

Mavrogeni, Sophie; Markussis, Vyron; Bratis, Konstantinos; Mastorakos, George; Sidiropoulou, Elpida J.; Papadopoulou, Evangelia; Kolovou, Genovefa

doi:10.1016/j.ijcard.2012.04.089

Cited by 21 publications

(17 citation statements)

References 11 publications

(2 reference statements)

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“…Many underwent CMR, which demonstrated myocarditis. Endomyocardial biopsy in selected patients revealed lymphocytic infiltration without viral infection, indicative of autoimmune etiology . This study demonstrated that (a) a large proportion of patients with hyperthyroidism suffer from cardiac symptoms; (b) myocarditis is often the underlying cause; and (c) persistent autoimmunity may cause inflammation in both the thyroid and myocardium, even in the absence of active viral infection.…”

Section: Discussionmentioning

confidence: 68%

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Acute autoimmune myocarditis as a manifestation of Graves’ disease: A case report and review of the literature

Lancaster

Koons

Lee

et al. 2019

Clinical Case Reports

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Section: Discussionmentioning

confidence: 68%

“…Endomyocardial biopsy in selected patients revealed lymphocytic infiltration without viral infection, indicative of autoimmune etiology. 16 This study demonstrated that (a) a large proportion of patients with hyperthyroidism suffer from cardiac symptoms; (b) myocarditis is often the underlying cause;…”

Section: Discussionmentioning

confidence: 89%

Acute autoimmune myocarditis as a manifestation of Graves’ disease: A case report and review of the literature

Lancaster

Koons

Lee

et al. 2019

Clinical Case Reports

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“…Several reports demonstrated that myocardial derangement was induced by autoimmune mechanism in the setting of autoimmune thyroid dysfunction. [6,7] The response of myocardial lesion to therapy in this case was dramatically demonstrated, which might have been derived from an anti-inflammatory effect of steroid pulse therapy. On the other hand, extracardiac inflammatory reactions, such as marked sIL-2R level increase, liver dysfunction, and lymph node swelling, were prolonged for several months after the initiation of therapy.…”

Section: Discussionmentioning

confidence: 78%

Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse

Kohno¹,

Amiya²,

Hatano³

et al. 2017

Medicine

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Rationale:Heart failure is relatively common in patients with hyperthyroidism, but thyrotoxic cardiomyopathy with poor left ventricular (LV) systolic function is very rare.Patient concerns:We experienced a representative case of a patient who presented with severe LV dysfunction related to thyroid storm and needed extracorporeal membrane oxygenation (ECMO) temporally.Diagnosis:Thyrotoxic cardiomyopathy.Interventions and Outcomes:Aggressive antithyroid therapy, including steroid pulse to hyperthyroidism, leads to the dramatic improvement of cardiac function and she was successfully weaned from ECMO.Lessons:The most outstanding feature of the current case was the rapid decrease of cardiac injury and improvement of cardiac function by strengthening antithyroid therapy, including steroid pulse, without thyroid hormone level normalization. In thyroid storm, various systemic inflammatory reactions have different time courses and among them, the cardiac phenotype emerges in most striking and critical ways.

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“…Mavrogeni et al [4] reported a case of hyperthyroidism combined with autoimmune myocarditis confirmed by myocardial biopsy. Our patient was first diagnosed with abnormal thyroid function, followed by myocardial damage.…”

Section: Sub-acute Thyroiditis and Myocarditismentioning

confidence: 99%

Sub-acute Thyroiditis and Myocardial Damage

Li¹,

Wang²,

Luo³

et al. 2018

Med Case Rep

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Chest pain is associated with electrocardiographic ST-T changes and elevated levels of myocardial damage markers and may be induced by acute coronary syndrome, myocarditis, stress cardiomyopathy, acute pericarditis, pulmonary embolism, and cerebrocardiac syndrome. Few studies have evaluated chest pain accompanied by electrocardiographic ST-T changes and elevated myocardial damage markers during sub-acute thyroiditis. We herein describe a 19-year-old man with sub-acute thyroiditis combined with myocardial damage and explore the mechanism of this condition.

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Hyperthyroidism induced autoimmune myocarditis. Evaluation by Cardiovascular Magnetic Resonance and endomyocardial biopsy

Cited by 21 publications

References 11 publications

Acute autoimmune myocarditis as a manifestation of Graves’ disease: A case report and review of the literature

Acute autoimmune myocarditis as a manifestation of Graves’ disease: A case report and review of the literature

Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse

Sub-acute Thyroiditis and Myocardial Damage

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