Hyperthyroidism Increases Brown Fat Metabolism in Humans

Lahesmaa, Minna; Orava, Janne; Schalin‐Jäntti, Camilla; Soinio, Minna; Hannukainen, Jarna C.; Noponen, Tommi; Kirjavainen, Anna; Iida, Hidehiro; Kudomi, Nobuyuki; Enerbäck, Sven; Virtanen, Kirsi A.; Nuutila, Pirjo

doi:10.1210/jc.2013-2312

Cited by 102 publications

(98 citation statements)

References 38 publications

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“…BAT thermogenesis is markedly increased in humans who have hyperthyroidism (86). Supraphysiologic doses of thyroid hormones are associated with serious side effects, prohibiting their therapeutic use to reduce body weight.…”

Section: Bat As a Potential Drug Target To Treat Obesity And Diabetesmentioning

confidence: 99%

Human Brown Adipose Tissue: What We Have Learned So Far

2015

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Brown adipose tissue (BAT) is a unique tissue that is able to convert chemical energy directly into heat when activated by the sympathetic nervous system. While initially believed to be of relevance only in human newborns and infants, research during recent years provided unequivocal evidence of active BAT in human adults. Moreover, it has become clear that BAT plays an important role in insulin sensitivity in rodents and humans. This has opened the possibility for exciting new therapies for obesity and diabetes. This review summarizes the current state of research with a special focus on recent advances regarding BAT and insulin resistance in human adults. Additionally, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and diabetes.

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Section: Bat As a Potential Drug Target To Treat Obesity And Diabetesmentioning

confidence: 99%

Human Brown Adipose Tissue: What We Have Learned So Far

2015

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“…In a different study using these 2 tracers, hyperthyroidism increased glucose uptake in BAT (and muscle, but not in WAT) with increased lipid oxidation and whole body energy expenditure, but BAT perfusion was not increased (unlike muscle which had increased perfusion). 54 These changes were reversed by restoration of euthyroidism. 54 Therefore increased 18 F-FDG uptake by BAT in PET scans provides limited information about the metabolic activity of BAT.…”

Section: Other Tracersmentioning

confidence: 99%

“…54 These changes were reversed by restoration of euthyroidism. 54 Therefore increased 18 F-FDG uptake by BAT in PET scans provides limited information about the metabolic activity of BAT.…”

Section: Other Tracersmentioning

confidence: 99%

Insights into Brown Adipose Tissue Physiology as Revealed by Imaging Studies

et al. 2014

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“…Although a comprehensive review about the relation of brown adipose tissue and thyroid hormones is beyond the scope of this review, Lahesmaa and cols. have shown that overt hyperthyroidism, which frequently leads to significant weight loss, is associated with a threefold greater BAT glucose uptake, with increased energy expenditure and greater use of lipids as an energy substrate (45). The relationship between brown adipose tissue and thyroid hormones is, however, known for decades (2,(46)(47)(48)(49)(50).…”

Section: Is Brown Adipose Tissue Metabolically Important In Humans?mentioning

confidence: 99%

Brown adipose tissue: what have we learned since its recent identification in human adults

Halpern

Mancini

Halpern

2014

Arq Bras Endocrinol Metab

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Brown adipose tissue, an essential organ for thermoregulation in small and hibernating mammals due to its mitochondrial uncoupling capacity, was until recently considered to be present in humans only in newborns. The identification of brown adipose tissue in adult humans since the development and use of positron emission tomography marked with 18-fluorodeoxyglucose (PET-FDG) has raised a series of doubts and questions about its real importance in our metabolism. In this review, we will discuss what we have learnt since its identification in humans as well as both new and old concepts, some of which have been marginalized for decades, such as diet-induced thermogenesis. Arq Bras Endocrinol Metab. 2014;58(9):889-99 Keywords Brown adipose tissue; obesity; thermogenesis; UCP-1; energy expenditure RESUMO O tecido adiposo marrom, órgão essencial para a termorregulação de animais hibernantes e pequenos devido à sua capacidade desacopladora, era até poucos anos considerado presente apenas em recém-nascidos na espécie humana. A identificação do tecido adiposo marrom em adultos com o desenvolvimento e uso da tomografia de emissão de pósitron marcado com 18-fluorodesoxiglicose (PET-FDG) gerou questões sobre sua real importância para nosso metabolismo. Nesta revisão, discutiremos o que aprendemos nesse tempo, assim como conceitos antigos e novos, alguns marginalizados por décadas, como a termogênese induzida por dieta. Arq Bras Endocrinol Metab. 2014;58(9):889-99 Descritores

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Hyperthyroidism Increases Brown Fat Metabolism in Humans

Abstract: Hyperthyroidism increases GU in BAT independently of BAT perfusion. Hyperthyroid patients are characterized by increased skeletal muscle metabolism and lipid oxidation rates.

Cited by 102 publications

References 38 publications

Human Brown Adipose Tissue: What We Have Learned So Far

Human Brown Adipose Tissue: What We Have Learned So Far

Insights into Brown Adipose Tissue Physiology as Revealed by Imaging Studies

Brown adipose tissue: what have we learned since its recent identification in human adults

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