Hyperthyroidism in a population with Down syndrome (DS)

Goday-Arno, Albert; Cerda-Esteva, Mariaina; Flores-Le-Roux, Juana A.; Chillarón-Jordan, Juan José; Corretger, J. M.; Cano-Pérez, Juan F.

doi:10.1111/j.1365-2265.2008.03419.x

Cited by 80 publications

(79 citation statements)

References 19 publications

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“…According to that very recent report, clinical features of GD in DS patients are similar to those found in the general population, with the exception of young age at diagnosis and no female predominance (5). Other salient features of GD in DS are the low prevalence of ophthalmopathy and the very short duration of clinical remission under carbimazole treatment (5).…”

Section: Introductionmentioning

confidence: 57%

“…Nevertheless, GD presentation in our DS patients occurred at a younger age and did not demonstrate any gender predominance, against that observed in the control group. These two peculiarities of GD in DS had already been described by Goday-Amo et al although that DS population was not compared with a control study population (5).…”

Section: Discussionmentioning

confidence: 93%

“…In childhood and adolescence, Hashimoto's thyroiditis (HT) is by far the most common autoimmune disease in DS (2)(3)(4). The prevalence of Graves' disease (GD) has also been recently reported to be clearly higher in DS children and adolescents (6.5%) than in the general population (5).…”

Section: Introductionmentioning

confidence: 99%

“…Other salient features of GD in DS are the low prevalence of ophthalmopathy and the very short duration of clinical remission under carbimazole treatment (5).…”

Section: Introductionmentioning

confidence: 99%

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Peculiarities of Graves' disease in children and adolescents with Down's syndrome

Luca¹,

Corrias²,

Salerno³

et al. 2010

European Journal of Endocrinology

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Objective: To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. Design and methods: The evolution over time of GD was determined in both groups according to the clinical changes and the variations in TSH, free thyroxine, and TSH receptor autoantibodies serum levels during the entire follow-up. Results: Female prevalence (50 vs 81.6%; c 2 Z12.0, P!0.0005) and average age at GD presentation (9.9G4.4 vs 11.5G3.5 years, P!0.05) were significantly lower in DS group than in controls. Clinical responsiveness to methimazole therapy was significantly better in DS patients, as demonstrated by both the lower relapse rates after the first cycle withdrawal (7.1 vs 31.2%; c 2 Z7.4, P!0.005) and the higher persistent remission rates after definitive therapy withdrawal (46.4 vs 26.7%; c 2 Z4.1, P!0.05). Moreover, in DS group, no patients needed surgery or radioiodine ablation, whereas nonpharmacological treatment was necessary in 11% of controls (c 2 Z3.8, P!0.05). Antecedents of Hashimoto's thyroiditis (HT) were documented in 21.4% of DS patients and in 3.7% of controls (c 2 Z10.4, P!0.005). Association with other autoimmune diseases was detected in 32.1% of DS cases and in 12.8% of controls (c 2 Z5.94, P!0.025). Conclusions: GD in DS children and adolescents is characterized by several peculiarities: i) earlier presentation; ii) no gender predominance; iii) less severe clinical course; iv) higher frequency of documented HT antecedents; v) more frequent association with other autoimmune diseases.

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Section: Introductionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

“…Other salient features of GD in DS are the low prevalence of ophthalmopathy and the very short duration of clinical remission under carbimazole treatment (5).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peculiarities of Graves' disease in children and adolescents with Down's syndrome

Luca¹,

Corrias²,

Salerno³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

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“…In a limited number of cases, HT was associated with either Turner syndrome (TS) or Down syndrome (DS), i.e., two chromosomopathies that are known to be linked with an increased risk of autoimmune diseases (17,18,19,20,21,22,23,24,25) and especially thyroid diseases (26,27,28,29,30,31).…”

Section: Introductionmentioning

confidence: 99%

Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology

Waśniewska

Aversa

Salerno

et al. 2015

European Journal of Endocrinology

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Aim: To follow-up for 5 years thyroid status evolution in 127 girls with mild (TSH 5-10 mU/l) subclinical hypothyroidism (SH) of different etiologies. Patients: The population was divided into two age-matched groups of 42 and 85 girls with either idiopathic (group A) or Hashimoto's thyroiditis (HT)-related SH (group B). Group B was in turn divided into three subgroups, according to whether SH was either isolated or associated with Turner syndrome (TS) or Down syndrome (DS). Results: At the end of follow-up the rate of girls who became euthyroid was higher in group A (61.9% vs 10.6%), whereas the rates of patients who remained SH (55.3% vs 26.2%), became overtly hypothyroid (30.6% vs 11.9%) or required levothyroxine (L-T 4 ) therapy (63.5% vs 23.8%) were higher in group B. Among the girls of group B, the risk of remaining SH or developing overt hypothyroidism was higher in the subgroups with TS or DS than in those with isolated HT. Conclusions: Long-term prognosis of mild and idiopathic SH is frequently benign, even though a L-T 4 treatment may be needed throughout follow-up in almost a quarter of cases; long-term prognosis is different in the girls with either idiopathic or HT-related SH; and the association with either TS or DS impairs the outcome of HT-related SH.

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Down Syndrome for the Otolaryngologist

Zalzal

Lawlor

2023

JAMA Otolaryngol Head Neck Surg

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ImportanceThere are many features of Down syndrome that prompt referral to an otolaryngologist. As the lifetime prevalence and life expectancy of individuals with Down syndrome increase, it is increasingly likely that otolaryngologists will have the opportunity to care for patients with Down syndrome.ObservationsA confluence of characteristics common to Down syndrome may be associated with issues in the head and neck, from infancy through adulthood. Hearing concerns range from narrow ear canals and cerumen impactions to eustachian tube dysfunction, middle ear effusion, cochlear malformations, and conductive, sensorineural, and/or mixed hearing loss. Immune deficiency, hypertrophy of Waldeyer ring, and hypoplastic sinuses may complicate and develop into chronic rhinosinusitis. Speech delay, obstructive sleep apnea, dysphagia, and airway anomalies are also common among this patient population. Because these concerns may necessitate otolaryngologic surgery, it is vital for otolaryngologists to familiarize themselves with anesthetic concerns, including cervical spine instability, in patients with Down syndrome. Comorbid cardiac disease, hypothyroidism, and obesity may also affect these patients and otolaryngologic care.Conclusions and RelevanceIndividuals with Down syndrome may visit otolaryngology practices at all ages. Otolaryngologists that familiarize themselves with the head and neck manifestations that are common among patients with Down syndrome and know when to order screening tests will be able to provide comprehensive care.

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Hyperthyroidism in a population with Down syndrome (DS)

Cited by 80 publications

References 19 publications

Peculiarities of Graves' disease in children and adolescents with Down's syndrome

Peculiarities of Graves' disease in children and adolescents with Down's syndrome

Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology

Down Syndrome for the Otolaryngologist

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