Hyperthyroidism from an Embryonal Carcinoma

Gama, Rousseau; Smith, M. G. M.; White, W F; Kwong, P Y P

doi:10.1177/014107689709000809

Cited by 5 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3. The most common and often the only presenting sign of bhCG-induced thyrotoxicosis in men is tachycardia, 2,6,7 as exempli¢ed in this case. Other features include very high oestradiol concentrations with gynaecomastia and the presence of widespread metastatic disease.…”

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 61%

“…We wish to raise four important points regarding the diagnosis, aetiology and management of beta human chorionic gonadotropin (bhCG)-induced hyperthyroidism. 1 1. bhCG-induced hyperthyroidism is characterized by very high levels of bhCG and these may cross-react in some TSH assays, 2,3 giving apparently normal rather than suppressed TSH values. Since many laboratories o¡er TSH as the ¢rst-line test in investigating thyroid dysfunction, the diagnosis of bhCGinduced hyperthyroidism may be missed.…”

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 99%

“…Other features include very high oestradiol concentrations with gynaecomastia and the presence of widespread metastatic disease. 2,6,7 4. Tumour bhCG-induced hyperthyroidism may require standard anti-thyroid treatment, but almost invariably responds to e¡ective tumour chemotherapy.…”

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 99%

“…1 We have previously raised concerns about these criteria, due to changes in troponin kits causing marked changes in apparent population 99th percentiles. 2 We have recently changed lot numbers for our troponin I assay on the Immulite 2000. The manufacturer warned users that there would be some changes in values at this change in lot number.…”

Section: Changes In Troponin Kits Preclude Meaningful Collection Of Data On Population 99th Percentilesmentioning

confidence: 99%

See 3 more Smart Citations

Testicular germ cell tumour presenting as thyrotoxicosis

Elfatih

Gama

2004

Ann Clin Biochem

Self Cite

View full text Add to dashboard Cite

Testicular germ cell tumour presenting as thyrotoxicosisWe wish to raise four important points regarding the diagnosis, aetiology and management of beta human chorionic gonadotropin (bhCG)-induced hyperthyroidism. 1 1. bhCG-induced hyperthyroidism is characterized by very high levels of bhCG and these may cross-react in some TSH assays, 2,3 giving apparently normal rather than suppressed TSH values. Since many laboratories o¡er TSH as the ¢rst-line test in investigating thyroid dysfunction, the diagnosis of bhCGinduced hyperthyroidism may be missed.2. bhCG exists as several isoforms dependent on carbohydrate content. Desialated isoforms, which are produced more abundantly in cases of bhCG-induced hyperthyroidism, have greater thyrotrophic activity than the more common sialated isoforms. 4,5 Therefore, the quality rather than the quantity of bhCG is important in the development of bhCG-induced hyperthyroidism. This also explains why the very high bhCG levels in pregnancy are not usually associated with thyrotoxicosis.3. The most common and often the only presenting sign of bhCG-induced thyrotoxicosis in men is tachycardia, 2,6,7 as exempli¢ed in this case. Other features include very high oestradiol concentrations with gynaecomastia and the presence of widespread metastatic disease. 2,6,7 4. Tumour bhCG-induced hyperthyroidism may require standard anti-thyroid treatment, but almost invariably responds to e¡ective tumour chemotherapy. Tumour relapse may also be associated with recurrence of the thyrotoxicosis. 2

show abstract

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 61%

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 99%

Section: Testicular Germ Cell Tumour Presenting As Thyrotoxicosismentioning

confidence: 99%

Section: Changes In Troponin Kits Preclude Meaningful Collection Of Data On Population 99th Percentilesmentioning

confidence: 99%

See 2 more Smart Citations

Testicular germ cell tumour presenting as thyrotoxicosis

Elfatih

Gama

2004

Ann Clin Biochem

Self Cite

View full text Add to dashboard Cite

show abstract

“…(1) β-hCG induced hyperthyroidism is characterised by very high concentrations of β-hCG and these may cross react in some assays for thyroid stimulating hormone (TSH)2 3 giving apparently normal rather than suppressed TSH values. Since many laboratories offer TSH as the first line test in investigating thyroid dysfunction, the diagnosis of β-hCG induced hyperthyroidism may, therefore, be missed.…”

mentioning

confidence: 99%