Hyperthyroid dementia: clinicoradiological findings and response to treatment

Reversible Changes in Brain Glucose Metabolism Following Thyroid Function Normalization in Hyperthyroidism

“…18 Recent functional brain imaging studies by using SPECT and FDG-PET demonstrated that thyroid hormones affect regional brain metabolism in patients with hyperthyroidism. 4,23 These studies showed a significantly reduced blood flow of the bilateral temporal-parietal cortex or a decreased metabolism of the uncus and the inferior temporal gyrus. Increased breathing and heart rates might inhibit metabolism of the brain stem.…”

“…4,18,23 Furthermore, different neuroimaging techniques, (eg, proton MR spectroscopy and SPECT with lipophilic radiotracers) were used in the studies of patients with hyperthyroidism. 18,23 Most interesting, the methods used to analyze data from the PET studies varied. Many PET studies were based on a region-of-interest approach that examined select regions originally reported by earlier studies.…”

Démences potentiellement curables

“…Celle-ci peut engendrer des modifications psychocomportementales telles qu'hyperémotivité, agitation, hyperactivité. Ce n'est que beaucoup plus rarement que les troubles cognitifs sont au premier plan : troubles de la mémoire, de l'attention, praxies visuoconstructives [24]. Là aussi des signes associés aident généralement au diagnostic : tremblement, signes géné-raux (perte de poids malgré un appétit conservé, sueurs, etc.…”

Young-Onset Dementia

“…111 Hypothyroidism and hyperthyroidism can cause cognitive decline. 134 Adrenal insufficiency may indicate X-linked adrenoleukodystrophy. 85,86 Hypoparathyroidism 135 and hyperparathyroidism 136 can be associated with dementia.…”