Hyperthyreose durch TSH-produzierendes chromophobes Hypophysenadenom

Hrubesch, M; Böckel, K; Vosberg, H.; Wagner, Hermann; Hauss, W. H.

doi:10.1007/978-3-642-85448-4_392

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…Of ten cases reported in the literature, only four are unequivocal cases of TSH-thyrotoxicosis due to a pituitary tumour, according to the criteria proposed above (Mornex et al, 1972;Tolis et al, 1978;Horn el al., 1976;Duello & Halmi, 1977). Six other well documented cases have provided indirect evidence of such a pathological state (Hamilton et al, 1970;Hrubesch et al, 1972;Baylis, 1976;Kourides er af., 1976;O'Donnel et al, 1973;Linquette et af., 1969).…”

Section: Discussionmentioning

confidence: 98%

Hyperthyroidism Due to a Pituitary TSH Secreting Tumour With Amenorrhoea‐galactorrhoea

Benoit

Pearson‐Murphy

Robert

et al. 1980

Clinical Endocrinology

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A 20-year-old female presented with thyrotoxicosis associated with amenorrhoea and galactorrhoea after oral contraceptive withdrawal. Serum TSH was persistently elevated (mean: 28 +/- 3.1 microU/ml during 24-h sampling and did not vary significantly after TRH, bromocriptine or somatostatin. Prolactin levels remained constantly at the upper limit of normal (mean: 20.6 +/- 2.1 ng/ml, with a minimal increase after TRH, a slight decrease after somatostatin (54%) and a marked decrease after bromocriptine (88.5%). Surgical exploration revealed an unusually firm tumour adherant to the wall of the sella turcia; electron microscopic study showed that it was composed almost exclusively of thyrotrophs. After a transient period of euthyroidism post-operatively, T3 toxicosis occurred with an increased TSH level (15.5 microU/ml) and a rise in TSH and alpha subunit in response to TRH. An increase in T4 followed while prolactin remained low.

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Section: Discussionmentioning

confidence: 98%

Hyperthyroidism Due to a Pituitary TSH Secreting Tumour With Amenorrhoea‐galactorrhoea

Benoit

Pearson‐Murphy

Robert

et al. 1980

Clinical Endocrinology

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“…A thyrotropin-producing pituitary adenoma is not a common disorder but to the best of our knowledge, there have been at least 22 cases reported previously in the literature and serum levels of TSH were determined by bioassay and/or radioimmunoassay (Jailer & Holub, 1960 ;Lamberg et al, 1969 ;Linquette et al, 1969 ;Hamilton et al, 1970 ;1972 ;Faglia et al, 1972 ;Mornex et al, 1972 ;Hrubesch et al, 1972 ;O'Donnell et al, 1973 ;Demura et al, 1973 ;Baylis, 1976 ;Horn et al, 1976 ;Kourides et al, 1976 ;Tolis et al, 1978 ;Duello & Halmi, 1977 ;Smallridge et al, 1979 ;Waldhausl et al, 1979 ;Afrasiabi et al, 1979 ;Werner, 1979 ;Azukizawa et al, 1980). We have observed a patient with a TSH producing adenoma ; he is the first of high stature and with clinical euthyroidism in spite of hypersecre-tion of thyroid hormones.…”

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confidence: 99%

A tsh secreting pituitary tumor accompanied by high stature: presentation of a case and review of the literature.

et al. 1981

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A 23-year-old man of high stature, with hypogonadism and bitemporal-upper-quadrant visual defects was found to have a pituitary tumor. He had a slightly enlarged struma, while he did not show any signs of hyperthyroidism. His serum TSH level (10.4 microunits/ml) was slightly elevated in spite of increased levels of serum thyroid hormone (T3 249 ng/dl, T4 12.0 microgram/dl). Neither the elevated serum TSH levels nor thyroidal uptake of 123I were suppressed after 7 days of 75 microgram triiodothyronine administration. Serum TSH levels did not increase further after TRH administration. Hypofunction of the anterior pituitary gland was observed. Following transsphenoidal hypophysectomy, his serum thyroid hormone and TSH levels returned to the normal range. Immunohistochemical examination revealed the existence of numerous TSH positive cells. From these data we concluded that the patient had a pituitary tumor which secreted inappropriate amounts of TSH.

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“…Some patients with increased TSH, T3 and T4 serum levels in association with the clinical picture of hyperthyroidism have had thyroid-stimulating hormone producing pituitary adenomas, either without other endocrine abnormalities (Jailer & Holub 1960;Hamilton et al 1970;Faglia et al 1972;Hrubesch et al 1972;Mornex et al 1972;O'Donnell et al 1973;Afrasiabi et al 1979;Reschini et al 1976;Kourides et al 1977) (Refetoff etal. 1967(Refetoff etal.…”

mentioning

confidence: 99%

Syndrome of'inappropriate secretion of thyroid-stimulating hormone' by partial target organ resistance to thyroid hormones

Diego¹,

Rodríguez²,

Orlando³

et al. 1981

Acta Endocrinologica

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Hyperthyreose durch TSH-produzierendes chromophobes Hypophysenadenom

Cited by 8 publications

References 13 publications

Hyperthyroidism Due to a Pituitary TSH Secreting Tumour With Amenorrhoea‐galactorrhoea

Hyperthyroidism Due to a Pituitary TSH Secreting Tumour With Amenorrhoea‐galactorrhoea

A tsh secreting pituitary tumor accompanied by high stature: presentation of a case and review of the literature.

Syndrome of'inappropriate secretion of thyroid-stimulating hormone' by partial target organ resistance to thyroid hormones

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