Hyperthermic Treatment of Intraocular Tumors

Finger, Paul T.; Packer, Samuel; Svitra, Paul P.; Paglione, R.W.; Chess, Jeremy; Albert, Daniel M.

doi:10.1001/archopht.1984.01040031197017

Cited by 54 publications

(5 citation statements)

References 25 publications

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“…Recent studies have shown that warming treatment improved the healing of acute and chronic wounds [12,13,17,18]. Local warming is known to increase microcirculatory perfusion, which enhances the uptake of oxygen and nutrients to the wound bed and stimulates cell growth [9,10].…”

Section: Introductionsupporting

confidence: 41%

Heat Treatment Enhances Healing Process of Experimental Pseudomonas Corneal Ulcer

Nanbu

Wakabayashi

Yamashita³

et al. 2004

Ophthalmic Res

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We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated corneas and the control corneas. The severity of infection and the degree of angiogenesis were classified by a clinical scoring system. The animals were euthanized 14 days after infection and the corneas were submitted for histopathological examination. The expression of vascular endothelial growth factor (VEGF) was examined immunohistochemically. Comparative reverse transcription polymerase chain reaction was performed to measure the expression level of VEGF in the cornea. Hyperthermia significantly promoted corneal epithelization and neovascularization in the PCU model. Heat treatment significantly decreased the number of viable Pseudomonas organisms present in PCU. On immunohistochemistry, the heated cornea demonstrated more intense staining for VEGF. Comparative reverse transcription polymerase chain reaction showed upregulation of the expression level of VEGF mRNA in the heat-treated cornea. Hyperthermia accelerated the healing process of PCU with increased corneal neovascularization. Angiogenesis may play an important role in the PCU healing process, which is enhanced by the heat treatment.

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Section: Introductionsupporting

confidence: 41%

Heat Treatment Enhances Healing Process of Experimental Pseudomonas Corneal Ulcer

Nanbu

Wakabayashi

Yamashita³

et al. 2004

Ophthalmic Res

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“…This conclusion can be drawn if one compares, e.g., the results of MW (3)(4)(5), OW (laser) (6-9) and US (10-14) hyperthermia treatment of ocular tumors.…”

Section: Introductionmentioning

confidence: 48%

<title>Comparative studies on hyperthermia induced by laser light, microwaves, and ultrasonics</title>

Greguss

1991

Future Trends in Biomedical Applications of Lasers

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Therapeutic heating takes back as far as 3000 B.C., but the therapeutical use of local temperature rise of 5_200 C above normal body temperature, called hyperthermia, was carried out only in the past few decades if we disregard moxibustion. Results obtained by various treatment modalities such as optical waves (laser light), microwaves (MW), radio frequency current (RE) or ultrasound (US) are compared, and a theory based on the assumption that tumor formation can be regarded as some sort of disturbance in the signal processing system of the given biological structure is presented, suggesting that not the locally generated heat alone, but the elevated temperature in relation to several environmental factors is responsible for cell killing. Therefore, the modality of creating hyperthermia may be of significance since various methods may change the thermal behavior of the cell environment in a specific way, which means that using two or more modalities the synergetic behavior could be exploited for a better result.

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“…5 The heat convection provided by the high blood flow in the choroid, coupled with attenuation of the treatment beam as it passes through tumor tissue, can be a limiting factor for treating the base of a tumor solely by hyperthermia. 19 Our experimental results illustrate markedly faster temperature increases at the base of a tumor using 1047-nm irradiation (15 seconds) compared with 805-nm irradiation (60 seconds). These observations are in accordance with a better depth of penetration at 1047 nm.…”

Section: Commentmentioning

confidence: 69%

“…The probe was placed at the base of the tumor because this area (distant from the laser and close to the choroid) is critical for tumor regrowth. 19…”

Section: In Vivo Temperature Measurementsmentioning

confidence: 99%

Treatment of Experimental Choroidal Melanoma With an Nd:Yttrium-Lanthanum-Fluoride Laser at 1047 nm

Krause

Xiong²,

Gragoudas³

et al. 2003

Arch Ophthalmol

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To evaluate the effect of a new infrared laser in the destruction of pigmented choroidal melanomas. Methods: B16F10 melanomas were implanted in the subchoroidal space of 64 rabbits (tumor height, 2.0-4.0 mm). Laser radiation from an Nd:yttrium-lanthanumfluoride laser (1047 nm) was delivered as a focused (beam waist, 25 µm; irradiance, 100 kW/cm 2) raster-scanned transpupillary beam. To investigate melanin heating, treatment with focused light was compared with collimated light (beam waist, 2 mm; irradiance, 16 W/cm 2). Finewire thermocouples were implanted at the base of 3 tumors for in vivo temperature measurements. Untreated animals were used as controls. Results: Of 64 animals, 27 received a single treatment with focused 1047-nm light. The rate of complete tumor eradication was 91% (10 of 11 animals) at a dosage of 125 J/cm 2 and 75% (9/12) at 63 J/cm 2 to 87 J/cm 2. The eradication rate dropped to 25% (1 of 4) at 38 J/cm 2 or less (PϽ.001). Continuous tumor growth was observed in all animals treated with collimated radiation and in untreated controls. Temperature measurements indicated that tissue heating at the tumor base was more rapid at 1047 nm than at 805 nm. Conclusions: These data suggest that a single treatment with a focused, raster-scanned beam at 1047 nm may play a role in the destruction of pigmented choroidal melanoma. Focused irradiation at 1047 nm may provide more effective submillisecond heating of melanin than collimated irradiation, resulting in immediate photothermal disruption of tumor cells.

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Hyperthermic Treatment of Intraocular Tumors

Cited by 54 publications

References 25 publications

Heat Treatment Enhances Healing Process of Experimental Pseudomonas Corneal Ulcer

Heat Treatment Enhances Healing Process of Experimental Pseudomonas Corneal Ulcer

<title>Comparative studies on hyperthermia induced by laser light, microwaves, and ultrasonics</title>

Treatment of Experimental Choroidal Melanoma With an Nd:Yttrium-Lanthanum-Fluoride Laser at 1047 nm

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