Hyperthermic intraperitoneal chemotherapy as consolidation treatment of advanced stage ovarian cancer

Abstract

To investigate the therapeutic efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) as consolidation treatment after completing first-line treatment in patients with advanced ovarian cancer. MethodsA retrospective chart review was conducted on patients treated at the Comprehensive Gynecologic Cancer Center between January 2014 and 2019. Based on the inclusion criteria, 24 eligible patients who received HIPEC (paclitaxel 175 mg/m 2 , for 90 min, at 42°C) (HIPEC group) as consolidation treatment after terminating the adjuvant chemotherapy were identified. Another 24 patients who met the inclusion criteria and did not receive HIPEC were matched, representing the non-HIPEC group. Disease-free survival (DFS) and overall survival (OS) were examined between the two groups. ResultsThe median DFS was 28.7 and 24.2 months in the HIPEC and non-HIPEC groups, respectively (P=0.688). The 3year DFS rates in the HIPEC and non-HPEC groups were 39.5% and 32.6%, respectively. However, the median OS was not determined. The 5-year OS rates in the HIPEC and non-HIPEC groups were 86.2% and 81.3%, respectively (P=0.850). One patient developed grade 3 neutropenia. Other patients experienced mild adverse events after HIPEC. ConclusionThis study suggests that consolidation HIPEC could not support the survival benefit after completing the first-line treatment for patients with advanced ovarian cancer, although no severe specific safety issues were found. Therefore, randomized trials evaluating consolidation HIPEC for the management of ovarian cancer are warranted.

No obvious advantage of hyperthermic intraperitoneal chemotherapy after interval debulking surgery in the treatment of advanced ovarian cancer: A retrospective study

“…One retrospective study ( 21 ) conducted by Ziying Lei et al showed that primary cytoreductive surgery with HIPEC was associated with better long-term survival. A retrospective study ( 22 ) conducted by Jieun Ko et al demonstrated that consolidation HIPEC has no specific survival benefit for patients with advanced ovarian cancer after completion of first-line treatment. A study ( 23 ) conducted by Jessica Jou et al resulted in an unexpected conclusion; the study revealed that HIPEC was associated with an increased risk for platinum-refractory or resistant disease in ovarian cancer patients who underwent NACT and IDS, while no benefit was shown in median PFS.…”

Comment on: hyperthermic intraperitoneal chemotherapy as consolidation treatment of advanced stage ovarian cancer

“…We read with great interest the study entitled “Hyperthermic intraperitoneal chemotherapy as consolidation treatment of advanced-stage ovarian cancer”- a retrospective chart review by Ko et al [ 1 ]. We appreciate the authors for conducting the trial on this promising futuristic aspect of HIPEC.…”