Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating

Drizdal, Tomas; Paulides, Margarethus M.; Holthe, Netteke van; Rhoon, Gerard C. van

doi:10.1080/02656736.2017.1383517

Cited by 27 publications

(22 citation statements)

References 29 publications

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“…[103][104][105][106][107]113,114,116 These actions, coupled with the technological advancements in HT delivery, planning, online thermometry, and adaptive temperature modulation, should encourage integration of HT with RT and/or CT not only in LACC but also in other sites. 105,[108][109][110][111][112][117][118][119][120][121]129 It is noteworthy that 3 modal-itiesdHTRT, HTCTRT, and CTRT(3wkly Pt)dmaintained their superiority in terms of safety and efficacy in LACC, even after the sensitivity analysis for all trials published during or after 2004. The outcomes of the 2 ongoing multicentric-randomized trials in LACCdnamely, OUTBACK 130 and INTERLACE 131 daddressing NACT þ CTRT(wkly Pt) versus CTRT(wkly Pt) and CTRT(wkly Pt) þ ACT versus CTRT(wkly Pt), respectively, would be of considerable interest.…”

Section: Discussionmentioning

confidence: 99%

“…The technological advances in hardware and software over the last decade have led to safer locoregional HT delivery, thermal treatment planning, thermal dose monitoring through noninvasive thermometry, and online adaptive temperature modulation. 105,[117][118][119][120][121] Temperature monitoring during HT in cervix cancer and the adjacent normal organs of bladder and rectum can be performed effectively through noninvasive temperature sensors. Effectiveness of HTRT over RT was also reported in an earlier pairwise meta-analysis in LACC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Datta

Stutz

Gómez

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

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Treatment options in locally advanced cervix cancer (LACC) have evolved around radiation therapy (RT) and/or chemotherapy (CT), hypoxic cell sensitizers, immunomodulators (Imm), and locoregional moderate hyperthermia (HT). A systematic review and network meta-analysis was conducted to synthesize the evidence for efficacy and safety in terms of long-term locoregional control (LRC), overall survival (OS), and grade !3 acute morbidity (AM) and late morbidity (LM). Five databases were searched, and 6285 articles (1974-2018) were screened per the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Fifty-nine randomized trials in untreated LACC without surgical intervention were shortlisted. These used 13 different interventions: RT alone and/or neoadjuvant CT (NACT), adjuvant CT (ACT), concurrent chemoradiation therapy (CTRT) (weekly cisplatin [CDDP]/3-weekly CDDP/combination CT with CDDP/non-CDDP-based CT), hypoxic cell sensitizers, Imm, or HT. Odds ratios (ORs) using random effects network meta-analysis were estimated. Interventions for each endpoint were ranked according to their corresponding surface under cumulative ranking curve values. Of the 9894 patients evaluated, the total events reported for LRC, OS, AM, and LM were 5431 of 8197, 4482 of 7958, 1710 of 7183, and 441 of 6333, respectively. ORs and 95% credible intervals (CrIs) for the 2 best strategies were HT þ RT versus CTRT þ ACT (OR, 1.23; 95% CrI, 0.49-3.19) for LRC, CTRT (3-weekly CDDP) versus HTCTRT (OR, 1.14; 95% CrI, 0.35-3.65) for OS, RT þ ACT versus RT (OR, 0.01; 95% CrI, 0.00-1.04) for AM, and NACT þ RT þ ACT versus RT þ Imm (OR, 0.42; 95% CrI, 0.02-7.39) for LM. The 3 interventions with the highest cumulative surface under cumulative ranking curve values for all 4 endpoints were HTRT, HTCTRT, and CTRT (3-weekly CDDP). Articles with low risk of bias and those published during 2004 to 2018 also retained these interventions as the best. Two-step cluster analysis grouped these 3 modalities in a single distinctive NotedAn online CME test for this article can be taken at https:// academy.astro.org.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Datta

Stutz

Gómez

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

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“…This promotes the performance by (i) affording a compact size of the antenna building block, (ii) enhancing EMF coupling to the subject, and (iii) enabling broadband characteristics of the antenna. Additionally, flowing water within the bolus could be used to allow for superficial cooling during thermal interventions . Without proper impedance matching by the water bolus, the reflection coefficient showed a single self‐resonance at ~ 645 MHz.…”

Section: Discussionmentioning

confidence: 99%

Wideband Self‐Grounded Bow‐Tie Antenna for Thermal MR

et al. 2020

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The objective of this study was the design, implementation, evaluation and application of a compact wideband self-grounded bow-tie (SGBT) radiofrequency (RF) antenna building block that supports anatomical proton ( 1 H) MRI, fluorine ( 19 F) MRI, MR thermometry and broadband thermal intervention integrated in a wholebody 7.0 T system. Design considerations and optimizations were conducted with numerical electromagnetic field (EMF) simulations to facilitate a broadband thermal intervention frequency of the RF antenna building block. RF transmission (B 1 + ) field efficiency and specific absorption rate (SAR) were obtained in a phantom, and the thigh of human voxel models (Ella, Duke) for 1 H and 19 F MRI at 7.0 T. B 1 + efficiency simulations were validated with actual flip-angle imaging measurements. The feasibility of thermal intervention was examined by temperature simulations (f = 300, 400 and 500 MHz) in a phantom. The RF heating intervention (P in = 100 W, t = 120 seconds) was validated experimentally using the proton resonance shift method and fiberoptic probes for temperature monitoring. The applicability of the SGBT RF antenna building block for in vivo 1 H and 19 F MRI was demonstrated for the thigh and forearm of a healthy volunteer. The SGBT RF antenna building block facilitated 19 F and 1 H MRI at 7.0 T as well as broadband thermal intervention (234-561 MHz). For the thigh of the human voxel models, a B 1 + efficiency ≥11.8 μT/√kW was achieved at a depth of 50 mm. Temperature simulations and heating experiments in a phantom demonstrated a temperature increase ΔT >7 K at a depth of 10 mm.The compact SGBT antenna building block provides technology for the design of integrated high-density RF applicators and for the study of the role of temperature in

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“…extending up to 6 cm from the surface, can be treated using standard superficial Lucite cone or current sheet applicators, but also with the HYPERcollar, a dedicated phased-array system for head and neck tumours. Treatment planning can be used to predict treatment efficacy and a simulation study in 24 patients retrospectively analysed the predicted treatment quality achievable by the different applicators [61]. This analysis showed that in general a better target coverage is achieved with the HYPERcollar.…”

Section: A Applicator Selectionmentioning

confidence: 99%

“…This analysis showed that in general a better target coverage is achieved with the HYPERcollar. However, adequate target coverage can also be achieved with a Lucite cone applicator for tumours extending up to 5 cm from the patient surface, provided that the aperture fully covers the target [61].…”

Section: A Applicator Selectionmentioning

confidence: 99%

Hyperthermia Treatment Planning: Clinical Application and Ongoing Developments

Kok

Crezee

2021

IEEE J. Electromagn. RF Microw. Med. Biol.

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Hyperthermia is a proven clinical anti-cancer treatment, used in combination with radiotherapy and/or chemotherapy. During hyperthermia, tumour tissue is heated to 40-43°C using radiofrequency or microwave antennas, which strongly enhances effectiveness of radiotherapy and chemotherapy. Hyperthermia treatment quality depends on tumour temperatures achieved and treatment planning (i.e. simulation and optimization of absorbed power and temperature distributions) could be very useful to ensure and improve treatment quality. Hyperthermia treatment planning was mainly a research tool for decades, because of high computational costs and limited quantitative accuracy of treatment planning predictions due to a lack of patient-specific tissue properties. Thanks to developments over the past decade, treatment planning becomes increasingly important in the clinical workflow. Presently, main clinical applications of hyperthermia treatment planning are 1) applicator selection, 2) heating ability evaluation and 3) on-line treatment guidance. To improve the reliability and further increase applicability of treatment planning, ongoing developments focus on 1) dielectric imaging to derive patient-specific dielectric properties, 2) advanced thermal modelling including discrete vasculature and 3) biological modelling to predict the radiosensitizing effect of hyperthermia in terms of equivalent radiation dose. The increased clinical application and ongoing efforts will further improve treatment quality.

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Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating

Cited by 27 publications

References 29 publications

Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Wideband Self‐Grounded Bow‐Tie Antenna for Thermal MR

Hyperthermia Treatment Planning: Clinical Application and Ongoing Developments

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