Hyperthermia synergizes with tissue factor knockdown to suppress the growth and hepatic metastasis of colorectal cancer in orthotopic tumor model

Li, Hui; Tian, Ming; Guo, Yu; Liu, Yucun; Wang, Xin; Zhang, Jing; Ji, Shou‐Ping; Zhu, Jing; Wan, Yao; Tang, Jianqiang

doi:10.1002/jso.23136

Cited by 2 publications

(2 citation statements)

References 30 publications

(37 reference statements)

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“…Hepatic metastasis of colorectal cancer (CRC) is closely associated with TF expression, and TF knockdown inhibits hepatic metastasis in vitro and in vivo via activation of apoptosis and autophagy (23,24). Furthermore, a TF-FVIIa inhibitor (FFRFVIIa) was found to be able to attenuate hepatic metastasis of CRC (25).…”

Section: Regulation Of the Coagulation And Fibrinolytic Systems In Hccmentioning

confidence: 99%

Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

Wang

et al. 2020

Oncol Rep

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Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibrinolytic factors could be associated with intrahepatic metastasis of HCC. Do the coagulation and fibrinolytic systems protect HCC cells against anoikis during infiltration and metastasis? Conversely, do the coagulation and fibrinolytic systems lead to immune escape of HCC cells by affecting the immune microenvironment of patients? The current review aimed to present a number of novel hypotheses for the treatment of HCC by exploring the mechanisms of coagulation and fibrinolytic factors in the regulation of cancer growth. Contents1. Introduction 2. Coagulation characteristics of cancer 3. Regulation of the coagulation and fibrinolytic systems in HCC 4. Role of the coagulation system in resistance of HCC cells to anoikis 5. uPA system and immunotherapy for HCC 6.

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Section: Regulation Of the Coagulation And Fibrinolytic Systems In Hccmentioning

confidence: 99%

Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

Wang

et al. 2020

Oncol Rep

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“…Ectopic expression of TF has been detected in several type of cancers, including cervical cancers [ 18 ], epithelial ovarian cancer (EOC) [ 24 ], breast cancer [ 25 ], brain tumors [ 26 ], pancreatic cancer [ 27 ], gastric cancer [ 28 ], prostate cancer [ 29 ], colorectal cancer (CRC) [ 30 ], lung cancer [ 31 ], melanoma [ 32 ], and several cancer cell lines, including human promyelocytic leukemia tumor cell lines HL-60, glioma cell line U343, gastric cell line KATOIII, SNU-5 and MKN-74, colon cancer line HCT116, epidermoid carcinoma cell line A431, melanoma cell line WM1341B and WM938A [ 4 ],[ 33 ]. In addition, endothelial cells of tumor blood vessels, fibroblast and inflammatory cells also express TF [ 34 ],[ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Tissue factor in tumor microenvironment: a systematic review

Han

Guo

et al. 2014

J Hematol Oncol

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The aberrant hemostasis is a common manifestation of cancer, and venous thromboembolism (VTE) is the second leading cause of cancer patients’ mortality. Tissue factor (TF), comprising of a 47-kDa transmembrane protein that presents in subendothelial tissues and leukocytes and a soluble isoform, have distinct roles in the initiation of extrinsic coagulation cascade and thrombosis. Laboratory and clinical evidence showed the deviant expression of TF in several cancer systems and its tumor-promoting effects. TF contributes to myeloid cell recruitment in tumor stroma, thereby remodeling of tumor microenvironment. Additionally, the number of TF-positive-microparticles (TF+MP) from tumor origins correlates with the VTE rates in cancer patients. In this review, we summarize our current understanding of the TF regulation and roles in tumor progression and clinical complications.

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Hyperthermia synergizes with tissue factor knockdown to suppress the growth and hepatic metastasis of colorectal cancer in orthotopic tumor model

Abstract: Hyperthermia in combination with TF-targeted therapy could be a potential approach for CRC treatment.

Cited by 2 publications

References 30 publications

Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

Tissue factor in tumor microenvironment: a systematic review

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