Hyperthermia Requiring Prolonged Administration of High-Dose Dantrolene in the Postoperative Period

Dantrolene

“…The maintenance regimen consists of multiple infusions of 1 mg/kg every 4-6 h or a continuous infusion of 0.25 mg/kg/h with a total duration of at least 24 h [105,106]. Longer infusions and higher administration rates are sometimes needed [107]. Since recrudescence occurs in 20 % of cases, continuous monitoring is needed for 48-72 h after the initial incident [105,108].…”