Hyperthermia Requiring Prolonged Administration of High-Dose Dantrolene in the Postoperative Period

DeRuyter, Marie L.; Wedel, Denise J.; Berge, Keith H.

doi:10.1213/00000539-199504000-00033

Cited by 2 publications

(3 citation statements)

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“…As discussed in a previous study, the time of onset may be delayed as much as six hours or more (DeRuyter et al, 1995). Other studies such as those conducted by Smith et al, (1997) suggest that patients receiving isoflurane may not manifest fulminant MH until much later in the clinical course.…”

Section: Implications For Nursingmentioning

confidence: 73%

“…Isoflurane not only seems to be associated with delayed triggering, but a case reported by Malignant Hyperthermia 35 DeRuyter, Wedel, and Berge (1995), indicate that isoflurane may also be associated with prolonged dantrolene treatment. In this case report the patient had undergone two prolonged anesthetics prior to the exposure to isoflurane.…”

Section: Clinical Studies Of Mh With Different Volatile Anestheticsmentioning

confidence: 99%

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Differences in the Onset and Severity of Symptoms of Malignant Hyperthermia with Different Inhalational Anesthetics

Solberg¹

1999

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Malignant hyperthermia (MH) is an uncommon inherited disorder of skeletal muscle in which commonly used anesthetics can trigger sustained skeletal muscle hypermetabolism in patients who may have had no symptoms previously. The onset and severity of clinical symptoms of MH are variable. Non-clinical studies and case reports have identified differences in the onset and severity of symptoms with the commonly used volatile anesthetics. The purpose of this study was to identify if there is a significant difference in the onset and severity of signs and symptoms of malignant hyperthermia in those MH-susceptible patients who received the different volatile anesthetics. A comparative descriptive research design was used. A retrospective review of the database at the (USUHS) MH muscle biopsy diagnostic center was done. The data collected was used to determine if there was a difference in the onset and severity of signs and symptoms of MH episodes with halothane compared to MH episodes of four other volatile anesthetics. For each of these groups, the following variables were assessed: highest temperature, highest end-tidal carbon dioxide, time from beginning of anesthetic until onset of first MH symptom, time of onset of anesthesia until initial treatment for MH, and the incidence of masseter spasm. Based on results of this study, there was no significant difference among the groups. As much of the pediatric data was excluded, the results may have been skewed. Further studies examining these differences between volatile anesthetics would be extremely valuable in understanding the pathophysiology of malignant hyperthermia.

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Section: Implications For Nursingmentioning

confidence: 73%

Section: Clinical Studies Of Mh With Different Volatile Anestheticsmentioning

confidence: 99%

Differences in the Onset and Severity of Symptoms of Malignant Hyperthermia with Different Inhalational Anesthetics

Solberg¹

1999

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“…A protracted clinical course, including relapses, may occur. [5][6][7][8][9][10] Characteristic MH findings in this patient included masseter spasm, tachycardia with ventricular arrhythmia, hypertension, and temperature elevation. Myoglobin and CPK values remained normal.…”

Section: Discussionmentioning

confidence: 99%