Hyperthermia on immune regulation: A temperature’s story

Clinically feasible approaches to potentiating cancer cell-based immunotherapies

“…HIFU can deliver a large amount of energy that is subsequently converted to thermal energy, resulting in tumor cell destruction with minimal damage to the surrounding tissue. 125 The results also demonstrate that immunogenic TAAs remain available in the tumor debris after HIFU ablation for effective presentation by DCs, increasing the number and activity of TILs. 126 …”

Enhanced Antitumor Effect of Curcumin Liposomes with Local Hyperthermia in the LL/2 Model

“…According to past studies, Curcumin can potentiates antitumor activity through multiple pathways, such as reversing T cell-mediated immune dysfunction (Bhattacharyya et al, 2010), preventing T cell apoptosis (Bhattacharyya et al, 2007). Recently Hyperthermia has been found to be immune regulation function through inducing of the 70-kDa heat shock protein family (Manjili et al, 2002;Calderwood et al, 2005;Zhang et al, 2008). It has been proved that HSP played a critical role in the regulation of immune, which activated the NK cell and dendritic cells (Calderwood et al, 2005;Dayanc et al, 2008).…”

Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

“…5 Compared to continuous HIFU, pulsed HIFU (pHIFU) with relatively low duty cycles (DCs) ( 10%) can significantly reduce the heat buildup in tissues through non-continuous energy deposition with lower temporal average intensity. These exposures can achieve relatively stable temperature elevation within a hyperthermia range of 39-44 C. 6,7 Numerous research studies and clinical reports support the finding that ultrasound-induced hyperthermia can provide a promising and potentially much safer alternative to conventional ultrasound-based cancer therapy. [6][7][8][9][10][11] Despite growing interest in utilizing pHIFU-induced hyperthermia for cancer treatment, it is also suggested that the elevated temperature at the focus should be restricted to be lower than 44 C to avoid undesirable bioeffects.…”

“…These exposures can achieve relatively stable temperature elevation within a hyperthermia range of 39-44 C. 6,7 Numerous research studies and clinical reports support the finding that ultrasound-induced hyperthermia can provide a promising and potentially much safer alternative to conventional ultrasound-based cancer therapy. [6][7][8][9][10][11] Despite growing interest in utilizing pHIFU-induced hyperthermia for cancer treatment, it is also suggested that the elevated temperature at the focus should be restricted to be lower than 44 C to avoid undesirable bioeffects. 5,6 However, most researchers just simply empirically select HIFU parameters for different applications.…”

“…[6][7][8][9][10][11] Despite growing interest in utilizing pHIFU-induced hyperthermia for cancer treatment, it is also suggested that the elevated temperature at the focus should be restricted to be lower than 44 C to avoid undesirable bioeffects. 5,6 However, most researchers just simply empirically select HIFU parameters for different applications. Although several numerical models have been proposed to simulate HIFUinduced temperature elevations in tissues/vessels, most numerical studies focused solely on continuous HIFU exposures and were only validated by experimental results obtained using in vitro phantoms or ex vivo tissues.…”