“…According to past studies, Curcumin can potentiates antitumor activity through multiple pathways, such as reversing T cell-mediated immune dysfunction (Bhattacharyya et al, 2010), preventing T cell apoptosis (Bhattacharyya et al, 2007). Recently Hyperthermia has been found to be immune regulation function through inducing of the 70-kDa heat shock protein family (Manjili et al, 2002;Calderwood et al, 2005;Zhang et al, 2008). It has been proved that HSP played a critical role in the regulation of immune, which activated the NK cell and dendritic cells (Calderwood et al, 2005;Dayanc et al, 2008).…”