Hyperthermia: is it an ominous sign after cardiac arrest?

Takasu, Akira; Saitoh, Daizoh; Kaneko, Naoyuki; Sakamoto, Toshihisa; Okada, Yoshiaki

doi:10.1016/s0300-9572(00)00360-9

Cited by 106 publications

(56 citation statements)

References 14 publications

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“…An antibiotic treatment could also be added in case of strong suspicion of infection. This point is in accordance with the guidelines recommending a gradual rewarming of the hypothermic patients (0.25-0.5°C per hour) and a treatment of pyrexia in the first 72 h post-CA [10,[19][20][21] .…”

Section: Discussionsupporting

confidence: 85%

The therapeutic hypothermia after resuscitated cardiac arrest caused by ventricular fibrillation: a retrospective study in Saint Pierre University Hospital

Libert

Mols

Dechamps

et al. 2014

JHA

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Background: Therapeutic hypothermia is recommended as soon as possible for the neurological protection of comatose patients after cardiorespiratory arrest (CA) caused by pulseless ventricular fibrillation (VF) or tachychardia (VT). This retrospective study evaluates the adherence to the hypothermia protocol in Emergency Department and Intensive Care Units of Saint Pierre University Hospital (SPUH). Methods:Retrospective analyses of the database records from the 1st January 2005 to the 31st December 2010 concerning all the out-of-hospital arrests due to ventricular fibrillation admitted alive in the hospital. Transferred or NTBR patients were excluded. Results:Of the 72 patients studied, 68% were discharged alive from the hospital, of which 84% were free of neurological sequelae. Hypothermia was used in 44 patients, unjustified in 5 cases. There were also 5 cases for which it was needed, but not applied. Hypothermia (32°C -34°C) was achieved in a median time of 9.5 hours (range: 1.5 hours -39 hours) and lasted a median 21 hours (range: 7 hours -31 hours). Hypothermic patient survival was 72.7%, with 81% good neurological outcome. Conclusion:The protocol application in our small study gives as good figures as previous studies. Few errors of inclusion and exclusion are still present. Implementation of a common protocol for Emergency Medical Service (EMS), Emergency Department (ED) and Intensive Care Unit (ICU) would shorten the time to obtain the target temperature. The creation and implementation of a specific register with CA patients who received hypothermia would lead to a better medical follow-up for the patient and improve the current knowledge related to this technique.

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Section: Discussionsupporting

confidence: 85%

The therapeutic hypothermia after resuscitated cardiac arrest caused by ventricular fibrillation: a retrospective study in Saint Pierre University Hospital

Libert

Mols

Dechamps

et al. 2014

JHA

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“…In a small case series, patients with temperatures Ͼ39°C in the first 72 hours after out-of-hospital cardiac arrest had a significantly increased risk of brain death. 63 When serial temperatures were monitored in 151 patients for 48 hours after out-ofhospital cardiac arrest, the risk of unfavorable outcome increased (odds ratio 2.3, 95% confidence interval [CI] 1.2 to 4.1) for every degree Celsius that the peak temperature exceeded 37°C. 64 A subsequent multicenter retrospective study of patients admitted after out-of-hospital cardiac arrest reported that a maximal recorded temperature Ͼ37.8°C was associated with increased in-hospital mortality (odds ratio 2.7, 95% CI 1.2 to 6.3).…”

Section: Post-cardiac Arrest Brain Injurymentioning

confidence: 99%

Post–Cardiac Arrest Syndrome

Neumar¹,

Nolan²,

Adrie³

et al. 2008

Circulation

1,231

398

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“…Only half of the febrile episodes are attributable to infection, with nosocomial pulmonary infections representing the largest contributor [19]. Observational and retrospective studies have demonstrated that fever is associated with poor neurological outcome in the first 72 h after cardiac arrest [20,21], stroke [22], intracerebral hemorrhage [23], subarachnoid hemorrhage [24], and traumatic brain injury [25][26][27]. In spinal cord injuries, animal studies have revealed that induced hyperthermia immediately after the injury is associated with increased tissue damage and worse outcomes compared to normothermic conditions [28].…”

Section: Detrimental Effects Of Fevermentioning

confidence: 99%

Therapeutic Hypothermia for Acute Neurological Injuries

2012

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Therapeutic hypothermia (TH) is the intentional reduction of core body temperature to 32°C to 35°C, and is increasingly applied by intensivists for a variety of acute neurological injuries to achieve neuroprotection and reduction of elevated intracranial pressure. TH improves outcomes in comatose patients after a cardiac arrest with a shockable rhythm, but other off-label applications exist and are likely to increase in the future. This comprehensive review summarizes the physiology and cellular mechanism of action of TH, as well as different means of TH induction and maintenance with potential side effects. Indications of TH are critically reviewed by disease entity, as reported in the most recent literature, and evidence-based recommendations are provided.

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Hyperthermia: is it an ominous sign after cardiac arrest?

Cited by 106 publications

References 14 publications

The therapeutic hypothermia after resuscitated cardiac arrest caused by ventricular fibrillation: a retrospective study in Saint Pierre University Hospital

The therapeutic hypothermia after resuscitated cardiac arrest caused by ventricular fibrillation: a retrospective study in Saint Pierre University Hospital

Post–Cardiac Arrest Syndrome

Therapeutic Hypothermia for Acute Neurological Injuries

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