Hyperthermia impairs retrieval of an overtrained spatial task in the Morris water maze

Rauch, Terry M.; Welch, D.I.; Gallego, L.

doi:10.1016/s0163-1047(89)90442-1

Cited by 18 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EM (25) also showed a 2 8C increase in body core temperature because of EMW exposure. This interference with performance is consistent with previous reports on hyperthermia induced amnesia following exposure to hot water [Misanin et al, 1979;Mactutus et al, 1980;Rauch et al, 1989], behavioral perturbations produced by EMW induced hyperthermia [Hunt et al, 1975;de Lorge, 1984;Akyel et al, 1991;Mickley and Cobb, 1998], and suppressed performance of trained tasks in animals after absorption of electromagnetic energy caused hyperthermia in excess of 1-2 8C [Michaelson and Elson, 1996]. In part, hyperthermia might induce memory impairment by reducing the motivation for food [Hamilton, 1963] or by degrading attention span.…”

Section: Body Temperaturesupporting

confidence: 90%

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Yamaguchi

Tsurita

Ueno

et al. 2003

Bioelectromagnetics

View full text Add to dashboard Cite

This study sought to clarify the effects of exposure to electromagnetic waves (EMW) used in cellular phones on learning and memory processes. Sprague-Dawley rats were exposed for either 1 h daily for 4 days or for 4 weeks to a pulsed 1439 MHz time division multiple access (TDMA) field in a carousel type exposure system. At the brain, average specific absorption rate (SAR) was 7.5 W/kg, and the whole body average SAR was 1.7 W/kg. Other subjects were exposed at the brain average SAR of 25 W/kg and the whole body average SAR of 5.7 W/kg for 45 min daily for 4 days. Learning and memory were evaluated by reversal learning in a food rewarded T-maze, in which rats learned the location of food (right or left) by using environmental cues. The animals exposed to EMW with the brain average SAR of 25 W/kg for 4 days showed statistically significant decreases in the transition in number of correct choices in the reversal task, compared to sham exposed or cage control animals. However, rats exposed to the brain average SAR of 7.5 W/kg for either 4 days or for 4 weeks showed no T-maze performance impairments. Intraperitoneal temperatures, as measured by a fiber optic thermometer, increased in the rats exposed to the brain average SAR of 25 W/kg but remained the same for the brain average SAR of 7.5 W/kg. The SAR of a standard cellular phone is restricted to a maximum of 2 W/kg averaged over 10 g tissue. These results suggest that the exposure to a TDMA field at levels about four times stronger than emitted by cellular phones does not affect the learning and memory processes when there are no thermal effects.

show abstract

Section: Body Temperaturesupporting

confidence: 90%

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Yamaguchi

Tsurita

Ueno

et al. 2003

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…For example, morphine induces both hyperthermia (Tulunay, 1980) and muscular rigidity (Walter & Kuschinsky, 1989), two effeets that could potentially impair place leaming. Although morphine did produce moderate hyperthermia in the present experiment, the magnitude of this hyperthermia (0.7° C) has been demonstrated to be insufficient to impair Morris water maze performance (Rauch et al, 1989). Morphine also produced muscular rigidity, particularly at the highest dose.…”

Section: Discussioncontrasting

confidence: 67%

Pretraining morphine impairs acquisition and performance in the Morris water maze: Motivation reduction rather than anmesia

McNamara

Skelton

1991

Psychobiology

View full text Add to dashboard Cite

Two experiments were designed to assess the contribution of eentral opioid systems to spatial memory in the rat. In Experiment 1, rats were given morphine (5, 10, or 20 mglkg), naloxone (2 mglkg), morphine (20 mglkg) plus naloxone (2 mglkg), or saline and were trained to locate either a submerged or a visible platform in the Morris water maze. Pretraining, but not posttraining, morphine dose-dependently impaired aequisition and retention ofthe submerged platform tasks. Morphine also impaired aequisition of the visible-platform task. N aloxone reversed the morphine defieits but had no effect on plaee or eue learning when administered alone. In Experiment 2, rats were given morphine (10 mglkg), naloxone (2 mglkg), or saline and were required to locate aseries of novel platform positions in either warm (38 0 C, low incentive) or cold (100 C, high incentive) water. Morphine-treated rats showed large defieits in the warm water but minimal deficits in the cold water for both the submerged and the visible platforms, suggesting that morphine impairs plaee and eue learning by redueing the ineentive to escape. 1989), (2) the Morris water maze requires the rat to escape from a pool of cool (18°-26°C) water (Morris,

show abstract

“…For instance, rats fail to recognize previously encountered objects when body temperature increases 3°C above normal (Mickley & Cobb, 1998), but they still remember to avoid aversive stimuli with increases of 4°C (Ahlers & Riccio, 1987). Memory loss has been reported when heat stress is experienced during memory acquisition (Ahlers & Riccio, 1987; Beck & Rankin, 1995; Teskey et al, 2012) and consolidation (Cerf & Otis, 1957; Jacobs & Sorenson, 1969; Kane & Jarvik, 1970; Misanin et al, 1979; Zhao et al, 2008), but also during information retrieval (Rauch et al, 1989; Teskey et al, 2012). Negative effects on memory may occur even when heat stress events happen days before the acquisition of new information.…”

Section: The State Of Knowledgementioning

confidence: 99%

The impacts of heat stress on animal cognition: Implications for adaptation to a changing climate

Soravia

Ashton

Thornton

et al. 2021

WIREs Climate Change

View full text Add to dashboard Cite

With global surface air temperature rising rapidly, extensive research effort has been dedicated to assessing the consequences of this change for wildlife. While impacts on the phenology, distribution, and demography of wild animal populations are well documented, the impact of increasing temperature on cognition in these populations has received relatively little attention. Cognition encompasses the mental mechanisms that allow individuals to process information from the surrounding environment, respond accordingly, and flexibly adjust behavior. Hence, it is likely to be a key factor in allowing animals to adjust adaptively to climate change. Captive studies show that heat stress can negatively affect cognitive performance not only in the short‐term but also in the long‐term, by altering cognitive development at early life stages. Field studies indicate that cognitive performance may affect survival and reproductive success. However, the link between heat stress, cognition, and fitness in wild animals has yet to be formally established. We propose a comprehensive research framework for the collection of robust empirical datasets on heat stress and cognitive performance in the wild. We then suggest how knowledge of heat stress impacts on cognitive performance could be applied to population viability models and wildlife management actions. We believe that a joint research effort encompassing the fields of thermal physiology, behavioral ecology, comparative cognition, and conservation science, is essential to provide timely mitigation measures against the potential impacts of climate change on wildlife. This article is categorized under: Climate, Ecology, and Conservation > Observed Ecological Changes

show abstract

Hyperthermia impairs retrieval of an overtrained spatial task in the Morris water maze

Cited by 18 publications

References 13 publications

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Pretraining morphine impairs acquisition and performance in the Morris water maze: Motivation reduction rather than anmesia

The impacts of heat stress on animal cognition: Implications for adaptation to a changing climate

Contact Info

Product

Resources

About