Hyperthermia Enhances the Cytotoxicity against Hypoxic Cells of RP-170, a New 2-Nitroimidazole Nucleoside Hypoxic Cell Sensitizer

Emi, Yasunori; Maehara, Yoshihiko; Kusumoto, Tetsuya; Baba, Hideo; Sakaguchi, Masakazu; Sugimachi, Keizō

doi:10.1159/000227428

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Radiosensitizers such as radiolabeled nitroimidazoles were reported with chemotherapy to kill tumor and monitor the effect of hyperthermia and hypoxia by MRI, PET, CT, SPECT [152][153][154][155][156][157][158]. Recently, technical advances in the field of multimodal multifunctional use of nanoparticles, now radiolabeled […”

Section: Effective Hyperthermia and Radiosensitizers Combined With Hymentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

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Abstract:Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.

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Section: Effective Hyperthermia and Radiosensitizers Combined With Hymentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

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“…We established a cell line (KSE-1) of human ESCC and examined the basic evidence regarding the effects of hyperthermia itself and its synergic effects on chemotherapy and radiotherapy 30) . We also performed in vitro examinations to evaluate the efficacy of hyperthermia regarding the timing of anticancer drug administration 31) and application of new sensitizers [32][33][34] . In addition, we recently examined the mechanism underlying the DNA damage mediated by the ATR-Chk1 and ATM-Chk2 pathways via a biomolecular approach 35) .…”

mentioning

confidence: 99%

Current Treatment and Application of Hyperthermia for Squamous Cell Carcinoma of the Esophagus

et al. 2017

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Squamous cell carcinoma of the esophagus (ESCC) is a fairly aggressive disease with a poor prognosis. Surgical resection has been the gold standard of treatment for localized ESCC. However, this carcinoma is fairly sensitive to radiation, as well as chemotherapeutic agents such as cisplatin and 5-fluorouracil. Based on clinical trials conducted mainly by the Japan Clinical Oncology Group (JCOG), preoperative chemotherapy is regarded as the standard treatment for resectable ESCC in Japan. We have applied hyperthermia to ESCC mainly as a preoperative treatment associated with chemoradiotherapy since it has been experimentally proven to enhance the anti-tumor effects of chemotherapeutic agents and irradiation. The long-term survival as well as histological effectiveness was reported to be better in patients who received preoperative hyperthermochemoradiotherapy (HCR) than in those who received preoperative chemoradiotherapy (CRT). Definitive CRT is frequently performed even for resectable ESCC, and salvage treatment for either remnant or recurrent diseases remains an important clinical problem. We have applied hyperthermia simultaneously with chemotherapy as a salvage treatment for such patients, and complete response as well as stable disease was achieved in several patients. Hyperthermia is a promising modality as a salvage treatment and has recently been incorporated into regimens including taxanes. Potential enhancement of hyperthermia with certain drugs should be experimentally evaluated, and the clinical application of Hyperthermia for esophageal cancer M. Morita et al.

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Preoperative hyperthermochemoradiotherapy for esophageal carcinoma

Nozoe

Saeki

Ito

et al. 2002

Surgery

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Hyperthermia Enhances the Cytotoxicity against Hypoxic Cells of RP-170, a New 2-Nitroimidazole Nucleoside Hypoxic Cell Sensitizer

Cited by 4 publications

References 12 publications

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Current Treatment and Application of Hyperthermia for Squamous Cell Carcinoma of the Esophagus

Preoperative hyperthermochemoradiotherapy for esophageal carcinoma

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