Hyperthermia and thermochemotherapy

Issels, Rolf D.

doi:10.1007/978-1-4615-3082-4_10

Cited by 11 publications

(5 citation statements)

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“…The reduction of the side effects of chemotherapy and an increase in its effectiveness is certainly a desired result. Preliminary studies of Engelhardt [110], Dahl [111], Hahn [112] Urano [113] and Issels [114] have revealed that hyperthermia showed a synergism with chemotherapy as well as with radiotherapy. We have summarized the synergism and activity of drugs and HT in various micro-environmental conditions, in The activity of drugs in presence of hyperthermia is in the majority of cases additive and increase with the increase of the temperature [112,115].…”

Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

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Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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show abstract

“…The preliminary studies of Engelhardt, Dahl, Urano and Issels have shown that hyperthermia demonstrates synergism in chemotherapy, as in radiotherapy (16)(17)(18)(19)(20). Table 1 summarizes the synergism and activity of some chemotherapeutic agents and HT under various microenvironmental conditions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oncological Hyperthermia Centers and Turkey Modeling Oncological Hyperthermia Centers and Turkey Modeling

Göksel

Demircioglu

2020

Preprint

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Background Hyperthermia is a radio/chemo sensitizing method effectively used in oncological treatments. These devices, which have been used effectively in many centers around the world in the treatment of cancer, are currently unavailable in our country. In this study, hyperthermia treatments that could be applied, the number of hyperthermia devices required and the potential effects in our country have been investigated in line with the applications of hyperthermia worldwide.Methods Based on the data obtained from certain reference centers the number and ratios of hyperthermia applications were determined and the data obtained was modeled according to the number of cancer cases in our country.Results According to the data obtained, an average of 375 patients are treated annually per hyperthermia device in relevant centers. When a similar projection is applied for our country, hyperthermia treatment can be applied to an average of 400 patients annually with 0,18 hyperthermia devices per one million population. According to this, considering the population and the annual cancer diagnosis rates, it is predicted that 13 deep regional hyperthermia devices are required across the country.Conclusion The presence of deep regional hyperthermia devices in comprehensive oncology centers that play an effective role in oncological treatment with modern radiotherapy devices and have enough radiation oncologists will significantly benefit the capacity to provide oncological treatment options holistically.

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“…Hyperthermia increases the permeability of chemotherapeutic agents into the tumor by causing vasodilation in tumor vascularization (14,15). The preliminary studies conducted by Engelhardt, Dahl, Urano, and Issels have shown that hyperthermia demonstrates synergism in CT as in RT (16)(17)(18)(19)(20). Table 1 summarizes the synergism and activity of some chemotherapeutic agents and HT under various microenvironmental conditions.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Oncological Hyperthermia Centers and Turkey Modeling Oncological Hyperthermia Centers and Turkey Modeling

Göksel

Demircioğlu

2020

ircmj

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Introduction and Objectives: The latest technology and current treatments are used in the treatment of cancer in Turkey; however, oncological hyperthermia devices are currently not available. This study aimed to demonstrate the necessity of oncological hyperthermia devices in Turkey where cancer treatment is performed effectively. In this direction, some important oncological hyperthermia centers have been examined to what kind of planning can be developed in this country. Materials and Methods: The data were collected regarding the number of patients who had undergone hyperthermia during the treatment of cancer and the distribution of oncological diagnoses, devices per population, and rate of hyperthermia use. Subsequently, a model was prepared for Turkey, and an evaluation was performed on the number of cancer patients that can be applied to this treatment and the need for the number of oncological hyperthermia devices. Results: According to the data obtained, an average of 375 patients are treated annually per hyperthermia device in relevant centers. When a similar projection is applied for Turkey, hyperthermia treatment can be applied to an average of 400 patients annually with 0.18 hyperthermia devices per one million population. According to this result, considering the population and the annual cancer diagnosis rates, it is predicted that 13 deep regional hyperthermia devices are required across the country. Conclusion: The presence of deep regional hyperthermia devices in comprehensive oncology centers plays an effective role in oncological treatment with modern radiotherapy devices. This condition along with the sufficient number of radiation oncologists will significantly benefit the capacity to provide oncological treatment options holistically.

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Hyperthermia and thermochemotherapy

Cited by 11 publications

References 50 publications

A Brief Overview of Hyperthermia in Cancer Treatment

A Brief Overview of Hyperthermia in Cancer Treatment

Evaluation of Oncological Hyperthermia Centers and Turkey Modeling Oncological Hyperthermia Centers and Turkey Modeling

The Evaluation of Oncological Hyperthermia Centers and Turkey Modeling Oncological Hyperthermia Centers and Turkey Modeling

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