Hyperthermia and Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis

Klaver, Y.L.B.; Hendriks, T.; Lomme, Roger M. L. M.; Rutten, H.J.T.; Bleichrodt, Robert P.; Hingh, Ignace H. J. T. de

doi:10.1097/sla.0b013e3182197102

Cited by 54 publications

(35 citation statements)

References 24 publications

(27 reference statements)

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“…Hyperthermia is widely used to this end, even though it is not effective with all chemotherapy drugs. [7][8][9] Five years ago, our group showed that high pressure closed intraperitoneal chemotherapy with cisplatin increased cisplatin penetration into the peritoneum, and increased survival in rats with peritoneal carcinomatosis of colorectal origin. 10 As open techniques of HIPEC might achieve better tissue concentrations than closed techniques according to a previous experimental work, 11 we hypothesized that high pressure could be achieved during open HIPEC.…”

mentioning

confidence: 99%

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Facy

Samman²,

Magnin

et al. 2012

Annals of Surgery

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confidence: 99%

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Facy

Samman²,

Magnin

et al. 2012

Annals of Surgery

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“…24 In a recent experimental study, normothermic and hyperthermic intraoperative perfusion were both effective in prolonging overall survival in rats with peritoneal carcinomatosis, and with both treatments several animals remained free of disease until the end of the follow-up period. 7 In a study by Zeamari et al, similar results were obtained, although no cytoreductive surgery was performed. 25 Also in the current study, the performance of EPIC (under normothermic conditions) was shown to be at least equally effective as the treatment including hyperthermia.…”

Section: Discussionmentioning

confidence: 63%

“…The peritoneal cancer index (PCI) representing the extent of peritoneal carcinomatosis was recorded as the sum of all scores, as described previously. 6,7 All animals underwent CS with standard resection of the greater omentum aiming at radical removal of all macroscopic tumor deposits. CS may include resection of fat pads, spleen, parts of the mesentery, and peritonectomy.…”

Section: Surgerymentioning

confidence: 99%

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Intraoperative versus Early Postoperative Intraperitoneal Chemotherapy after Cytoreduction for Colorectal Peritoneal Carcinomatosis: an Experimental Study

et al. 2011

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Background. Perioperative intraperitoneal chemotherapy is used as an adjunct to cytoreductive surgery (CS) for peritoneal carcinomatosis (PC) in order to prolong survival. Worldwide, hyperthermic intraperitoneal chemotherapy (HIPEC), early postoperative intraperitoneal chemotherapy (EPIC), and combinations of the two are used. It remains unclear which regimen is most beneficial. Methods. The rat colon carcinoma cell line CC-531 was injected into the peritoneal cavity of 80 WAG/Rij rats to induce PC. Animals were randomized into four treatment groups (n = 20): CS only, CS followed by HIPEC (mitomycin 35 mg/m 2 at 41.5°C), CS followed by EPIC during 5 days (i.p. injection of mitomycin on day 1 and 5-fluorouracil on days 2-5), and CS followed by HIPEC plus EPIC. Primary outcome was survival. Results. In rats treated with CS only, median survival was 53 days (95% confidence interval (CI) 49-57 days). In rats treated with CS followed by HIPEC, survival was significantly (P = 0.001) increased (median survival 94 days, 95% CI 51-137 days). In the group treated with EPIC after CS, 12 out of 20 rats were still alive at the end of the experiment (P \ 0.001 as compared with CS only). In the group receiving both treatments, 11 rats died of toxicity, and therefore this group was not included in the survival analysis.Conclusions. Both EPIC and HIPEC were effective in prolonging survival. The beneficial effect of EPIC on survival seemed to be more pronounced than that of HIPEC.Further research is indicated to evaluate and compare the possible benefits and adverse effects associated with both treatments.

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“…8 Hyperthermia combined with radiation treatment, chemotherapy or photodynamic therapy may improve the e±cacy of cancer therapies. [9][10][11][12][13] Some studies found that injecting nanoparticles into the tumor also improved the cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Carbon-coated magnetic particles increase tissue temperatures after laser irradiation

Liu

Chen

Pang

et al. 2015

J. Innov. Opt. Health Sci.

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Purpose: This work focused on the investigation the hyperthermia performance of the carboncoated magnetic particles (CCMPs) in laser-induced hyperthermia. Materials and methods: We prepared CCMPs using the organic carbonization method, and then characterized them with transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, vibrating sample magnetometer (VSM) and X-ray di®raction (XRD). In order to evaluate their performance in hyperthermia, the CCMPs were tested in laser-induced thermal therapy (LITT) experiments, in which we employed a fully distributed¯ber Bragg grating (FBG) sensor to pro¯le the tissue's dynamic temperature change under laser irradiation in real time. Results: The sizes of prepared CCMPs were about several micrometers, and the LITT results show that the tissue injected with the CCMPs absorbed more laser energy, and its temperature increased faster than the contrast tissue without CCMPs. Conclusions: The CCMPs may be of great help in hyperthermia applications.

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Hyperthermia and Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis

Cited by 54 publications

References 24 publications

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Intraoperative versus Early Postoperative Intraperitoneal Chemotherapy after Cytoreduction for Colorectal Peritoneal Carcinomatosis: an Experimental Study

Carbon-coated magnetic particles increase tissue temperatures after laser irradiation

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