Hypertention in the Elderly

Nakamura, Yasuyuki; Tamaki, Shinji; Okamura, Tomio; Kadowaki, Tadashi; Hayakawa, Taketo; Kita, Y.; Kanda, Hideaki; Okayama, Akira; Ueshima, Hirotsugu

doi:10.1097/00004872-200402001-00404

Cited by 1 publication

(3 citation statements)

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“…6,9,[14][15][16][17][18][19][20][21][22][23][24] Figure 1 describes the selection of cohorts and participants. In the present analysis, we excluded 7 cohorts with no data on cause of death, [14][15][16] information on antihypertensive medication unavailable, [17][18][19] or cardiovascular death was not reported among treated workers.…”

Section: Study Populationsmentioning

confidence: 99%

“…Thus, the number of participants analyzed totaled 39 705 ( Figure 1 and Table 1). 6,9,[21][22][23][24] …”

Section: Study Populationsmentioning

confidence: 99%

“…The National Vital statistics of the Ministry of Health, Labor, and Welfare, Japan, for determining causes of death were obtained in all cohorts. 6,9,[21][22][23][24] Death certificates were also used for the ascertainment and definition of fatal events in 2 cohorts (Hisayama 6 and Ohasama). 9 Other sources including autopsy, 6 medical records, 6,9 health examination, 9,22 and questionnaires were also appropriately used.…”

Section: Risk Ascertainment and Follow-upmentioning

confidence: 99%

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Cardiovascular Risk With and Without Antihypertensive Drug Treatment in the Japanese General Population

Asayama¹,

Satoh²,

Murakami³

et al. 2014

Hypertension

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Abstract-To evaluate the cardiovascular mortality risk in association with blood pressure level among people with and without antihypertensive treatment, we performed the participant-level meta-analysis that included 39 705 Japanese from 6 cohorts (58.4% women; mean age, 60.1 years; 20.4% treated). Multivariable-adjusted Cox models were used to analyze the risk of cardiovascular mortality and its subtypes among 6 blood pressure levels according to recent guidelines, optimal to Grade 3 hypertension, and the usage of antihypertensive medication at baseline. During median 10.0 years of follow-up, there were 2032 cardiovascular deaths (5.1 per 1000 person-years), of which 410 deaths were coronary heart disease, 371 were heart failure, and 903 deaths were stroke. Treated participants had significantly higher risk for cardiovascular mortality (hazard ratios, 1.50; 95% confidence intervals, 1.36-1.66), coronary heart disease (hazard ratios, 1.53; confidence intervals, 1.23-1.90), heart failure (hazard ratios, 1.39; confidence intervals, 1.09-1.76), and stroke (hazard ratios, 1.48; confidence intervals, 1.28-1.72) compared with untreated people. Among untreated participants, the risks increased linearly with an increment of blood pressure category (P≤0.011). The risk increments per blood pressure category were higher in young participants (<60 years; 22% to 79%) than those in old people (≥60 years; 7% to 15%) with significant interaction for total cardiovascular, heart failure, and stroke mortality (P≤0.026). Among treated participants, the significant linear association was also observed for cardiovascular mortality (P=0.0003), whereas no stepwise increase in stroke death was observed (P=0.19). The risks of cardiovascular mortality were ≈1.

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