Hypertensive-Ischemic Ulcer

Woolling, Kenneth R.

doi:10.1001/jama.1964.03060160024006

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…Skin grafting has also used 14,15 with some success. Other therapies applied include cod liver oil, 3 typhoid vaccine, 3 intra-arterial novocaine 16 and IV calcium thionate.…”

Section: Discussionmentioning

confidence: 99%

Martorell’s hypertensive leg ulcer: case report and concise review of the literature

2001

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Hypertensive leg ulcers (Martorell's ulcers) are a unique form of lower extremity ischaemic leg ulcer. First described by Martorell, and Hines and Farber in the 1940s, these ulcers are defined by pain disproportionate to the size of the ulcer, specific location on the lower extremity, female-to-male predominance, association with long-standing, often poorly, controlled hypertension, and healing response to specific antihypertensive

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“…Skin grafting has also used 14,15 with some success. Other therapies applied include cod liver oil, 3 typhoid vaccine, 3 intra-arterial novocaine 16 and IV calcium thionate.…”

Section: Discussionmentioning

confidence: 99%

Martorell’s hypertensive leg ulcer: case report and concise review of the literature

2001

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Topical Treatment of Hypertensive Leg Ulcers With Platelet-Derived Growth Factor-BB

Senet

Vicaut²,

Bénéton³

et al. 2011

Arch Dermatol

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Setting: Ambulatory or hospitalized patients from 17 dermatology departments. Patients: Among 64 consecutive randomized patients with 1 or more hypertensive leg ulcers who fulfilled all inclusion criteria, 59 received the allocated intervention, and findings were analyzed. Intervention: Becaplermin gel (human recombinant platelet-derived growth factor-BB, 0.1%, in hydrogel) or hydrogel dressing was applied, both in doses of 1 cm/ cm 2 , once daily for 8 weeks. Follow-up continued for 4 weeks beyond the final gel application. Main Outcome Measures: The primary end point was complete wound closure rate after 8 weeks of treatment. Secondary end points were percentages of patients with complete wound closure at week 12; changed ulcer area after treatment vs baseline; and changed ulcerrelated pain and health-related quality of life during the study. Results: Complete wound closure rates were comparable after 8 weeks for becaplermin (5 of 28 patients) and hydrogel (3 of 31 patients) (8 percentage-point difference; 95% confidence interval,-10% to 26%). No statistically significant differences were observed between the 2 groups for percentages of complete closure at week 12, changed ulcer area at week 8, or changed ulcer-related pain and quality of life during the study (PϾ.05 for all comparisons). Conclusions: Topical becaplermin gel is not superior to hydrogel dressing for hypertensive leg ulcer wound closure. Surgical management by grafting remains the most promising treatment strategy but requires further evaluation.

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Martorell's hypertensive ischemic leg ulcers are secondary to an increase in the local vascular resistance

Duncan

Faris

1985

Journal of Vascular Surgery

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Hypertensive-Ischemic Ulcer

Cited by 9 publications

References 4 publications

Martorell’s hypertensive leg ulcer: case report and concise review of the literature

Martorell’s hypertensive leg ulcer: case report and concise review of the literature

Topical Treatment of Hypertensive Leg Ulcers With Platelet-Derived Growth Factor-BB

Martorell's hypertensive ischemic leg ulcers are secondary to an increase in the local vascular resistance

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