Hypertensive Disorders of Pregnancy

Wilkerson, R. Gentry; Ogunbodede, Adeolu C.

doi:10.1016/j.emc.2019.01.008

Cited by 125 publications

(124 citation statements)

References 62 publications

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“…Durante a segunda fase, uma isquemia é causada por hipoperfusão da placenta, que leva à liberação de vários mediadores, como a tirosina quinase-1 do tipo fms solúvel (sFlt-1), causando disfunção endotelial e uma cascata de distúrbios sistêmicos: hipertensão, edema, proteinúria e agregação plaquetária. A ativação das plaquetas e a cascata de coagulação levam ao desenvolvimento de microtrombos, piorando ainda mais o fluxo sanguíneo para o útero (WILKERSON & OGUNBODEDE, 2019;ELFARRA, BEAN, MARTIN, 2016;OLSON-CHEN et al, 2016).…”

Section: Resultsunclassified

Educação ambiental na UBS Parque Verde: relato da intervenção do grupo de biomedicina do PET-Saúde Graduasus/famaz

Alves¹,

Cruz²,

Ferreira³

et al. 2020

Saúde Pública: Novos Paradigmas Para a Ciência

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Section: Resultsunclassified

Educação ambiental na UBS Parque Verde: relato da intervenção do grupo de biomedicina do PET-Saúde Graduasus/famaz

Alves¹,

Cruz²,

Ferreira³

et al. 2020

Saúde Pública: Novos Paradigmas Para a Ciência

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“…Hypertensive disorders of pregnancy, especially pre-eclampsia and eclampsia, are the leading causes of maternal and fetal mortality and morbidity worldwide, accounting for 16% of direct maternal deaths [1]. According to the Global Burden of Disease 2000 report, the pooled incidence of pre-eclampsia in developing countries was estimated to be 3.4%, and it has certainly been on the rise as the years have progressed [2].…”

Section: Introductionmentioning

confidence: 99%

An Objective Histopathological Scoring System for Placental Pathology in Pre-Eclampsia and Eclampsia

Donthi

Malik

Mohamed

et al. 2020

Cureus

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Background and objective Pre-eclampsia and eclampsia are common complications in pregnancy, and they lead to uteroplacental vascular insufficiency. More than 38% of pregnant women succumb to seizures without meeting the clinical criteria for pre-eclampsia or eclampsia. This highlights the importance of a confirmatory diagnosis of preeclampsia or eclampsia using the histopathological changes seen in the placenta. Hence, the present study aimed to validate an objective histopathological scoring system of the placenta for an appropriate diagnosis of pre-eclampsia or eclampsia. Material and methods In this prospective study spanning two years, 50 cases of pre-eclampsia/eclampsia and 50 control subjects with normal placenta were included. The histomorphological changes in the placenta were examined for both groups and a scoring system was formulated to assess the severity of pre-eclampsia/eclampsia syndrome. A maximum score of 2 and a minimum score of 0 was assigned for maternal floor infarcts, calcification, villous basement membrane thickening, and fibrin deposition. Syncytial knots were assigned a minimum score of 0 and a maximum score of 1. The association of various placental histopathological variables with a clinical diagnosis of pre-eclampsia, eclampsia, and control was analyzed using the chisquared/Fisher's exact test. A one-way analysis of variance (ANOVA) test was used for comparing objective histopathological scores between pre-eclampsia, eclampsia, and control groups. A p-value of less than 0.05 was considered to be statistically significant. Results We found a significant association between each histopathological parameters of the placenta, including fibrin deposition, maternal floor infarction, calcification, villous basement membrane thickening, and syncytial knots, and clinical diagnosis of pre-eclampsia, eclampsia, and control groups. A median score of 2 significantly correlated with the normal group, while median scores of 4 and 6 correlated with pre-eclampsia and eclampsia respectively. Conclusion This comprehensive scoring system can be a basis for validating reporting patterns of the placenta in preeclampsia and eclampsia patients, as well as other disorders related to maternal uteroplacental insufficiency.

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“…Preeclampsia, a disorder characterized by hypertension and proteinuria during pregnancy, affects 5 to 8% of pregnant women worldwide and is a leading cause of obstetric complications [1]. In addition to hypertension and proteinuria, these patients also experience placental ischemia, endothelial dysfunction, end-organ ischemia, and vascular complications [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization

Chen

Lai

et al. 2020

Preprint

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Background Very few previous studies have examined the effect of endocrine parameters during ART on preeclampsia. Moreover, there is little known about the relationship of steroid hormone levels on development of the placenta. The purpose of this study is to assess the association of preeclampsia with serum estradiol (E2) and progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods This was a hospital-based cohort study using clinical data from the Kaohsiung Chang Gung Memorial Hospital Obstetric and Neonatal Database (KCGMHOND) from Jan 1, 2001 to December 1, 2018. Eligible women underwent at least one autologous IVF/ICSI cycle and had a live-born infant with a gestational age (GA) of more than 20 weeks. Results A total of 622 women who had live births after fresh IVF/ICSI-ET during the study period met our inclusion criteria. Twenty-eight women (4.5%) met the diagnostic criteria for preeclampsia. However, women in the preeclampsia group had a significantly higher body mass index (22 vs. 24, p =0.05), body weight at delivery (70.0 vs. 80.5 kg, p <0.001) and gestational weight gain (13.0 vs. 19.6 kg, p =0.002) and had lower use of ICSI (29.9% vs. 10.7%, p =0.021). Logistic regression analysis of the relationship of patient and treatment characteristics with preeclampsia. The crude ORs indicated that young female age >34, not using ICSI, E2 peak <1200 pg/mL and gestational weight gain >20 kg were associated with preeclampsia. After adjustment for confounding, the only factors that remained significant were E2 peak <1200 pg/mL (aOR = 4.634, 95% CI = 1.061 to 20.222), and gestational weight gain >20 kg (aOR: 13.601, 95% CI: 3.784, 48.880). Conclusions For women receiving IVF/ICSI, lower estradiol hormone levels on the day of hCG administration and higher pregnancy weight gain are related with subsequent preeclampsia.

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Hypertensive Disorders of Pregnancy

Cited by 125 publications

References 62 publications

Educação ambiental na UBS Parque Verde: relato da intervenção do grupo de biomedicina do PET-Saúde Graduasus/famaz

Educação ambiental na UBS Parque Verde: relato da intervenção do grupo de biomedicina do PET-Saúde Graduasus/famaz

An Objective Histopathological Scoring System for Placental Pathology in Pre-Eclampsia and Eclampsia

Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization

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