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“…This section briefly discusses biomarkers that support the diagnosis of PPCM and could result from underlying disease mechanisms. Furthermore, while the cause of PPCM is currently unknown, several risk factors have been proposed, including heart failure-associated genetic defects 89 , ethnicity 4,90 , hypertensive disorders 91 , infections 92 , twin and subsequent pregnancies 93 , and previous cancer 94 .…”
Section: Biomarkers and Risk Factorsmentioning
confidence: 99%
“…Whether the increased cardiovascular risk is due to direct consequences of the underlying cause of pre-eclampsia or due to shared risk factors is currently unknown 91,126,127 . A substudy of the ESC EORP described the differences in phenotypes and outcomes of PPCM patients with and without hypertensive disorders, including pre-eclampsia 91 .…”
Section: Pre-eclampsia and Vascular Dysfunctionmentioning
confidence: 99%
“…Whether the increased cardiovascular risk is due to direct consequences of the underlying cause of pre-eclampsia or due to shared risk factors is currently unknown 91,126,127 . A substudy of the ESC EORP described the differences in phenotypes and outcomes of PPCM patients with and without hypertensive disorders, including pre-eclampsia 91 . Patients with PPCM and pre-eclampsia presented with worse symptoms, but the LVEF of women with both diseases was more likely to recover than in PPCM patients without hypertension 91 .…”
Section: Pre-eclampsia and Vascular Dysfunctionmentioning
Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with varying incidences among countries and races. The cause of PPCM is uncertain but it may result from a combination of environmental and genetic factors, as well as pregnancy associated conditions such as pre-eclampsia. Animal studies suggested that impaired vascular and metabolic function may be central to the development of PPCM. Clarifying the pathogenic mechanisms is necessary to establish new therapies to improve the outcomes of patients with PPCM. Pregnancy hormones tightly coordinate a plethora of maternal adaptive responses, including haemodynamic, vascular, structural, and metabolic changes of the cardiovascular system. While pregnancy is considered to be a cardiovascular challenge, hormonal effects uniquely drive systemic insulin resistance and mostly fatty acid-dependent cardiac metabolism. In PPCM, the peripartum period is associated with profound and rapid hormonal changes that result in a brief period of disrupted cardiovascular (metabolic) homeostasis prone to secondary perturbations. This review summarizes and reflects on recent literature on the potential pathophysiological mechanisms and risk factors for PPCM with a focus on the maternal cardiovascular changes associated with pregnancy. We provide an updated framework to improve understanding of PPCM pathogenesis, which may lead to a better disease definition.
“…This section briefly discusses biomarkers that support the diagnosis of PPCM and could result from underlying disease mechanisms. Furthermore, while the cause of PPCM is currently unknown, several risk factors have been proposed, including heart failure-associated genetic defects 89 , ethnicity 4,90 , hypertensive disorders 91 , infections 92 , twin and subsequent pregnancies 93 , and previous cancer 94 .…”
Section: Biomarkers and Risk Factorsmentioning
confidence: 99%
“…Whether the increased cardiovascular risk is due to direct consequences of the underlying cause of pre-eclampsia or due to shared risk factors is currently unknown 91,126,127 . A substudy of the ESC EORP described the differences in phenotypes and outcomes of PPCM patients with and without hypertensive disorders, including pre-eclampsia 91 .…”
Section: Pre-eclampsia and Vascular Dysfunctionmentioning
confidence: 99%
“…Whether the increased cardiovascular risk is due to direct consequences of the underlying cause of pre-eclampsia or due to shared risk factors is currently unknown 91,126,127 . A substudy of the ESC EORP described the differences in phenotypes and outcomes of PPCM patients with and without hypertensive disorders, including pre-eclampsia 91 . Patients with PPCM and pre-eclampsia presented with worse symptoms, but the LVEF of women with both diseases was more likely to recover than in PPCM patients without hypertension 91 .…”
Section: Pre-eclampsia and Vascular Dysfunctionmentioning
Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with varying incidences among countries and races. The cause of PPCM is uncertain but it may result from a combination of environmental and genetic factors, as well as pregnancy associated conditions such as pre-eclampsia. Animal studies suggested that impaired vascular and metabolic function may be central to the development of PPCM. Clarifying the pathogenic mechanisms is necessary to establish new therapies to improve the outcomes of patients with PPCM. Pregnancy hormones tightly coordinate a plethora of maternal adaptive responses, including haemodynamic, vascular, structural, and metabolic changes of the cardiovascular system. While pregnancy is considered to be a cardiovascular challenge, hormonal effects uniquely drive systemic insulin resistance and mostly fatty acid-dependent cardiac metabolism. In PPCM, the peripartum period is associated with profound and rapid hormonal changes that result in a brief period of disrupted cardiovascular (metabolic) homeostasis prone to secondary perturbations. This review summarizes and reflects on recent literature on the potential pathophysiological mechanisms and risk factors for PPCM with a focus on the maternal cardiovascular changes associated with pregnancy. We provide an updated framework to improve understanding of PPCM pathogenesis, which may lead to a better disease definition.
“…In this issue of the Journal, Jackson and colleagues present more fascinating data on the phenotypic spectrum of women with PPCM and the overlap with hypertensive disorders of pregnancy from a large global registry. 8 The investigators are to be congratulated for the impressive feat of collecting data on 752 women from across 51 countries, allowing them to provide novel insights into a rare and understudied condition. The results reiterate the frequent co-existence of hypertensive disorders with PPCM; almost 40% of women with PPCM were diagnosed with either hypertension or PE.…”
Section: This Article Refers To 'Hypertensive Disorders In Women With...mentioning
“…Peripartum cardiomyopathy (PPCM) usually occurs during pregnancy or soon after delivery, in the absence of other causes of HF. 24,25 The extent of hypertension in women with PPCM has been investigated by Jackson et al 26 using data from the European Society of Cardiology EURObservational Research Programme PPCM Registry. Maternal and neonatal outcomes were analysed in three phenotypes of women: PPCM with no hypertension (PPCM-noHTN), hypertension with no pre-eclampsia (PPCM-HTN) and PPCM with pre-eclampsia (PPCM-PE).…”
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