Hypertensive Disorders in Pregnancy: Frequency and Associated Factors in a Cohort of Brazilian Women

Gaio, Dea Suzana Miranda; Schmidt, María Inês; Duncan, Bruce Bartholow; Nucci, Luciana Bertoldi; Matos, M. C.; Branchtein, Leandro

doi:10.1081/prg-100107829

Cited by 65 publications

(62 citation statements)

References 24 publications

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“…In the population studied, this demonstrates the presence of pregestational chronic hypertension (CH), which was a significant risk factor for superimposed preeclampsia in this study, thus corroborating the findings from other studies 10,13,15,22 . This is an important finding, since in the current social setting a growing number of women who become pregnant after 30 years of age is observed, which increases the probability of their having CH or developing PESCH during pregnancy 24 . In these cases, preconceptional advice and a high quality prenatal care are essential 13 .…”

Section: Discussionmentioning

confidence: 99%

“…The risk of PE in non-white pregnant women was 14.085 times that of white pregnant women. This likely occurred because the black race presents a higher prevalence of hypertension when compared to the white race in the general population 24 .…”

Section: Discussionmentioning

confidence: 99%

“…This shows that not only the number but also the quality of the prenatal visits should be considered, thus enabling a proper identification of risk factors for HSP and its early diagnosis, which are fundamental in the secondary prevention 11,13,23,24 . As regards the risk factors, in this study, age above 30 years was a risk factor for PESCH, independently of obesity and previous preeclampsia; it was also a protective factor for PE.…”

Section: Discussionmentioning

confidence: 99%

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Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Assis¹,

Viana²,

Rassi³

2008

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Assis¹,

Viana²,

Rassi³

2008

Arq. Bras. Cardiol.

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“…It is diagnosed when the patient presents blood pressure of 140/90 mmHg or more, in two separate measurements at least four to six hours apart, and proteinuria (> 0.3 g/24 h). 1,2 The incidence of preeclampsia is approximately 3-5%, 1,3,4 although in some populations it may reach up to 10%. 5 Its prevalence is also variable: 10 to 20%.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for cardiovascular disease ten years after preeclampsia

et al. 2010

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CONTEXT AND OBJECTIVE: Preeclampsia is a gestational disease that occurs mainly among nulliparous women after the 20 th week of gestation, and frequently close to delivery. The effects of preeclampsia on women's blood pressure over the long term are still controversial. Patients with recurrent preeclampsia or preeclampsia in the early stages of pregnancy appear to present higher risk of hypertension. The aim of this study was to determine the risk factors for cardiovascular disease among women with preeclampsia 10 years earlier. DESIGN AND SETTING:Cross-sectional study at Hospital de Clínicas de Porto Alegre (HCPA). METHODS:Forty women with preeclampsia and 14 normotensive pregnant women followed up 10 or more years earlier at HCPA underwent clinical and laboratory examinations. Spearman's correlation coefficient was used to correlate body mass index (BMI) and systolic and diastolic pressures. The risk of developing hypertension was measured using the chi-square test. P < 0.05 was considered significant. RESULTS:The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure (P = 0.047), BMI (P = 0.019) and abdominal circumference (P = 0.026). They presented positive correlations between BMI and diastolic blood pressure (0.341; P = 0.031) and between BMI and systolic blood pressure (0.407; P = 0.009). CONCLUSION:The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure, BMI and abdominal circumference than did the control group. This emphasizes the importance of long-term follow-up assessment for cardiovascular risk factors among patients with preeclampsia.RESUMO CONTEXTO E OBJETIVO: Pré-eclâmpsia é uma doença gestacional que ocorre principalmente em mulheres nulíparas, após a vigésima semana de gestação e frequentemente próximo do parto. Os efeitos da pré-eclâmpsia sobre a pressão sanguínea das mulheres a longo prazo ainda são controversos.Pacientes com pré-eclâmpsia recorrente ou pré-eclâmpsia na fase inicial da gestação parecem apresentar maior risco para hipertensão. O objetivo foi determinar os fatores de risco para doença cardiovascular em mulheres com pré-eclâmpsia há 10 anos. TIPO DE ESTUDO E LOCAL: Estudo transversal, realizado no Hospital de Clínicas de Porto Alegre (HCPA).MÉTODO: Quarenta mulheres com pré-eclâmpsia e 14 mulheres grávidas com pressão arterial normal acompanhadas há 10 anos ou mais no HCPA foram submetidas a exames clínicos e laboratoriais. Para se encontrar a correlação entre índice de massa corporal (IMC) e as pressões sistólica e diastólica, foi calculado o coeficiente de correlação de Spearman. O risco de desenvolvimento de hipertensão foi calculado através do teste de qui-quadrado. P < 0,05 foi considerado significante. RESULTADOS:Pacientes com pré-eclâmpsia há 10 anos ou mais tiveram pressão arterial diastólica (PAD) (P = 0,047), IMC (P = 0,019) e circunferência abdominal (P = 0,026) mais elevadas e apresentaram correlações positivas entre IMC e PAD (0,341, P = 0,031) e sistólica (0,4...

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“…3 In a Brazilian cohort of midpregnant women, 7.5% presented hypertensive disorders and 2.3% had pre-eclampsia/eclampsia. 4 The occurrence of such disorders in a specific period of women lives may have consequences thereafter. The association between pre-eclampsia or hypertensive diseases of pregnancy and ensuing events, such as cardiovascular diseases, hypertension and mortality due to any cause, was shown in epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

Association between pregnancy-related hypertension and severity of hypertension

et al. 2008

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Hypertension in pregnancy is an emerging sex-specific risk factor for cardiovascular disease and may lead to more severe hypertension after pregnancy. The objectives of this study were to investigate the frequency of pregnancy-related hypertension among patients referred to a hypertension clinic and its association with the severity of hypertension and evidence of end-organ damage. In this cross-sectional study, women with hypertension were submitted to a systematic clinical evaluation. The occurrence of pregnancy-related hypertension was investigated by questionnaire. The association between pregnancy-related hypertension and severity of hypertension (stage 2 according to Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VII)) and end-organ damage was assessed in a logistic regression model. The mean age, systolic and diastolic blood pressure and body mass index (BMI) of the 768 women examined were 51.6 ± 12.7 years, 158.2 ± 26.6 mm Hg, 93.8 ± 14.3 mm Hg and 29.4±5.6 kg/m 2 , respectively. The proportion of women with pregnancy-related hypertension was 32.9%. It was significantly associated with hypertension at stage 2 (OR: 1.60, 95% CI: 1.14-2.24; P ¼ 0.01) after controlling for confounders. The occurrence of a pregnancy-related hypertension was not associated with evidence of optic fundi abnormalities, left ventricular hypertrophy or abnormalities in kidney function. In conclusion, pregnancy-related hypertension is frequent in women referred to a hypertension clinic, and is associated with severe hypertension but not with evidence of end-organ damage.

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Hypertensive Disorders in Pregnancy: Frequency and Associated Factors in a Cohort of Brazilian Women

Cited by 65 publications

References 24 publications

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Risk factors for cardiovascular disease ten years after preeclampsia

Association between pregnancy-related hypertension and severity of hypertension

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