Hypertensive crisis precipitated by a monoamine oxidase inhibitor in a patient with phaeochromocytoma.

Cook, Rosalind; Katritsis, D

doi:10.1136/bmj.300.6724.614-a

Cited by 16 publications

(6 citation statements)

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“…The use of certain drugs such as histamine, metoclopramide, glucagon, etc. may also precipitate a hypertensive episode (Barancik, 1989; Bittar, 1979; Cook and Katritsis, 1990; Jan et al, 1990; Manger and Gifford, 1996; Page et al, 1969; Schorr and Rogers, 1987; Steiner et al, 1968). Moreover, micturition or bladder distension in the case of a pheochromocytoma of the urinary bladder can cause clinical symptoms and signs of catecholamine excess.…”

Section: Presentmentioning

confidence: 99%

Pheochromocytoma and Paraganglioma

Kantorovich

Pacák

2010

Neuroendocrinology - Pathological Situations and Diseases

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Pheochromocytoma is a very special kind of tumor full of duplicity. On the one hand it represents its own microworld with unique clinical, biochemical and pathological features, while on the other it constitutes a tremendously significant part of whole body system, playing a vital role for practically every organ system. It has a very special character – sometimes like a child it can be sweet and predictable, while at times it can behave like a deadly wild beast, crashing and tearing everything on its path in a fierce rage. It also consists of the amazingly intelligent neuroendocrine cells that possess a magical ability to make miraculous substances of many kinds. But most of all, it is a system that is able to drive our curiosity and the itch of “Cogito, ergo sum” to limitless depths and year by year it still amazes us with new and unexpected discoveries that move our understanding of multiple pathways and metabolic events closer to the ultimate truth. Recent discoveries of succinate dehydrogenase (SHD) and prolyl hydroxylase (PHD) mutations, for example, propelled our understanding of neuroendocrine tumorigenesis as a whole, as well as physiology of mitochondrial respiratory chain and phenomenon of pseudohypoxia in particular. Good old discoveries make their way from dusty repositories to shine with new meaning, appropriate for the current level of knowledge. This acquired wisdom makes us better physicians – knowing the specific expression makeup of catecholamine transporters, GLUTs and SRIFs allows for better tailored imaging and therapeutic manipulations. There are still long ways to go, keeping in mind that pheochromocytoma is but so very special, and we are optimistic and expect many great things to come.

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Section: Presentmentioning

confidence: 99%

Pheochromocytoma and Paraganglioma

Kantorovich

Pacák

2010

Neuroendocrinology - Pathological Situations and Diseases

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“…The use of certain drugs such as histamine, metoclopramide, glucagon, etc. may also precipitate a hypertensive episode (Barancik, 1989;Bittar, 1979;Cook and Katritsis, 1990;Jan et al, 1990;Manger and Gifford, 1996;Page et al, 1969;Schorr and Rogers, 1987;Steiner et al, 1968). Moreover, micturition or bladder distension in the case of a pheochromocytoma of the urinary bladder can cause clinical symptoms and signs of catecholamine excess.…”

Section: Clinical Presentationmentioning

confidence: 99%

Pheochromocytoma and Paraganglioma

Pacák

Wimalawansa

2015

Endocrine Practice

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“…MAO inhibitors are contraindicated in patients with or on suspicion of a PHEO. When there would be a hypertensive crisis due to excess release of catecholamines by the PHEO, the clearance of circulating catecholamines would be reduced by the MAO inhibitor [ 9 , 16 ]. When there are severe hypertensive episodes in patients taking MAO inhibitors regardless of a dietary restriction of tyramine, a PHEO should be suspected [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

An Adrenal Mass and Increased Catecholamines: Monoamine Oxidase or Pheochromocytoma Effect?

et al. 2015

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Hormonal evaluation in patients with an adrenal incidentaloma can be difficult in patients with comorbidities or in patients using interfering drugs. We present a case of a 54-year-old man who was evaluated for an adrenal mass. The medical history reported treatment with a monoamine oxidase (MAO) inhibitor for recurrent psychoses. Hormonal screening showed elevated levels of normetanephrine and metanephrine in plasma and urine, suggesting a diagnosis of pheochromocytoma (PHEO), and an adrenalectomy was performed. Histologic examination showed that the tumor had an origin of the adrenal cortex. MAO inhibitors are also known to cause elevated levels of catecholamines. In this case, a PHEO seemed more likely the cause due to repeatedly elevated levels of metanephrines and normal levels of catecholamines. Since the tumor had an origin of the adrenal cortex, the use of MAO inhibitors was the most likely explanation for the elevated levels of metanephrines. This case illustrated the difficulties in diagnosing PHEO, especially in patients with comorbidities and interfering drugs.

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Hypertensive crisis precipitated by a monoamine oxidase inhibitor in a patient with phaeochromocytoma.

Cited by 16 publications

References 0 publications

Pheochromocytoma and Paraganglioma

Pheochromocytoma and Paraganglioma

Pheochromocytoma and Paraganglioma

An Adrenal Mass and Increased Catecholamines: Monoamine Oxidase or Pheochromocytoma Effect?

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