Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer: methodological issues

Karamzad, Nahid; Ayubi, Erfan; Rahmani, Vahid; Safiri, Saeid

doi:10.1007/s00345-016-1974-4

Cited by 15 publications

(6 citation statements)

References 3 publications

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“…VIF values <2 were regarded to indicate no multicollinearity. The variables with limited data (few in number), were excluded from calculations because of risk of sparse-data bias [42][43][44]. Kaplan-Meier (Log Rank) was used to construct survival analyses plot.…”

Section: Statistical Analysesmentioning

confidence: 99%

Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study

et al. 2020

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Section: Statistical Analysesmentioning

confidence: 99%

Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study

et al. 2020

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“…It may be argued that the value of regression coefficients is highly reliant on univariate prescreening of variables and type of multivariable analysis. 5,6 Response to "Comments on Treatment Strategies and Prognostic Factors of Limited-Stage Primary Small Cell Carcinoma of the Esophagus"…”

Section: Comments On "Treatment Strategies and Prognostic Factors Of mentioning

confidence: 99%

Comments on “Treatment Strategies and Prognostic Factors of Limited-Stage Primary Small Cell Carcinoma of the Esophagus”

Safiri

Ayubi

Mansori

2018

Journal of Thoracic Oncology

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occurred in separate cellular clones. The level of the C797S mutation is expected to be similar to or lower than the level of the T790M mutation if both mutations are present in the same cells, and it would show either concomitant increase or decrease in response to the combination therapy. The levels of each EGFR mutation measured by digital droplet polymerase chain reaction from a series of plasma samples indicated that the T790M and C797S mutations were likely present in different tumor cells, a finding that as we suggested in our article, may be due to multiple clones with individual mutations and resultant differences in tyrosine kinase sensitivity. 3 In the blood collected before the combination therapy, the levels of the T790M and C797S mutations were detected at mutant allele frequencies of 2.8% and 4.5%, respectively. This indicates that the overall load of C797S-positive tumor was higher than that of T790M-positive tumor before the combination therapy. The observed clinical improvement without reduction in T790M or exon 19 deletion also supports this hypothesis of clonal heterogeneity rather than the mutation being present in the same cells. Definitive proof, however, would require single-cell analysis, which is not possible for this patient.

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“…Hence, their finding may be biased by multicollinearity, and some statistically significant associations may not be detected because multicollinearity saps the power of statistical tests. 4,5 Finally, the authors constructed a Cox proportional hazards regression model, but the main assumption was not checked. The proportional hazards assumption must be initially checked, and variants of Cox proportional hazards regression models such as extended Cox models should be applied when this important assumption is violated.…”

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confidence: 99%

Dietary isoflavone intake and all‐cause mortality in breast cancer survivors: The Breast Cancer Family Registry—methodological issues

Ayubi

Safiri

2017

Cancer

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Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer: methodological issues

Cited by 15 publications

References 3 publications

Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study

Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study

Comments on “Treatment Strategies and Prognostic Factors of Limited-Stage Primary Small Cell Carcinoma of the Esophagus”

Dietary isoflavone intake and all‐cause mortality in breast cancer survivors: The Breast Cancer Family Registry—methodological issues

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